DOI QR코드

DOI QR Code

Clinical Efficacy of herbal medicine for Chemo-Radiotherapy-induced oral mucositis

  • SongWon Park (Dept. of Oriental Internal Medicine, Graduate School, Dongguk University) ;
  • MinJee Kim (Department of Rehabilitation Medicine of Korean Medicine, Dongguk University) ;
  • Seong-Woo Lim (Dept. of Oriental Internal Medicine, Graduate School, Dongguk University)
  • 투고 : 2022.10.19
  • 심사 : 2022.11.09
  • 발행 : 2022.12.01

초록

Objectives: The purpose of this systematic review was to evaluate the effects of herbal medicine on Chemo-Radiotherapy-induced oral mucositis. Methods: Electronic databases were used to search for studies published through 10 years until October 2022, and a randomized controlled study was conducted to evaluate efficacy of herbal medicine on chemo-radiotherapy-induced oral mucositis. Study quality was assessed using the Cochran's risk bias tool. Results: Two-hundred and three articles were initially searched, and 11 studies (head and neck cancer, breast cancer, colorectal cancer, esophageal cancer etc. undergoing radio-chemotherapy were included in analysis. The effect of herbal medicine on chemo-radiotherapy-induced oral mucositis, 9 studies reported that herbal medicine was more effective than the placebo group or conventional treatment. One study reported that the effect of the herbal compound treatment group was similar to that of the conventional herbal medicine, and one study reported that there was no difference in effect between the two herbal medicines and the group without treatment. Conclusion: This study suggests that herbal medicine effectively relieves the symptoms of chemo-radiotherapy-induced oral mucositis. However, there is limited evidence that herbal medicine may relief chemo-radiotherapy-induced oral mucositis, so further investigation is needed.

키워드

참고문헌

  1. Elad, S., Cheng, K. K. F., Lalla, R. V., Yarom, N., Hong, C., Logan, R. M., et al. (2020). Mascc/isoo clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 126(19). 4423-4431. https://doi.org/10.1002/cncr.28592
  2. da Cruz Campos, M. I.Neiva Campos, C.Monteiro Aarestrup, F. & Vieira Aarestrup, B. J. (2014). Oral mucositis in cancer treatment: Natural history, prevention and treatment. Molecular and clinical oncology. 2(3). 337-340. https://doi.org/10.3892/mco.2014.253
  3. Zhang, Q.-Y.Wang, F.-X.Jia, K.-K. & Kong, L.-D. (2018). Natural product interventions for chemotherapy and radiotherapy-induced side effects. Frontiers in pharmacology. 9(1253. https://doi.org/10.3389/fphar.2018.01253
  4. Kim, H.-S.Choi, J.-E. & Yoo, H.-S. (2011). The effectiveness of gargling hwangryunhaedok-tang on chemotherapy-induced stomatitis. The Journal OF Korean Oriental Oncology. 16(1). 1-14. https://doi.org/10.15432/JKTO.2011.16.1.001
  5. Kamide, D.Yamashita, T.Araki, K.Tomifuji, M. & Shiotani, A. (2017). Hangeshashinto (tj-14) prevents radiation-induced mucositis by suppressing cyclooxygenase-2 expression and chemotaxis of inflammatory cells. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 19(11). 1329-1336. https://doi.org/10.1007/s12094-017-1672-8
  6. Kono, T., Kaneko, A., Matsumoto, C., Miyagi, C., Ohbuchi, K., Mizuhara, Y., et al. (2013). Sa1755 multi-target prevention of chemotherapy-induced oral mucositis by hangeshashinto: Pge2 and cell migration in human oral keratinocytes. Gastroenterology. 144(5, Supplement 1). S-299. https://doi.org/10.1016/S0016-5085(13)61067-7
  7. Kono, T., Kaneko, A., Matsumoto, C., Hibino, T., Shigenobu, T., Miyano, K., et al. (2013). Effect of hangeshashinto on wound healing in hamster 5-fluorouracil-induced oral mucositis model with increased keratinocyte migration and reduced inducible prostaglandin e2. American Society of Clinical Oncology. https://doi.org/10.1200/jco.2013.31.4_suppl.432
  8. Park, J.-W.Oh, J.Ko, S.-J.Chang, M. S. & Kim, J. (2018). Effects of onchung-eum, an herbal prescription, on 5-fluorouracil-induced oral mucositis. Integrative cancer therapies. 17(4). 1285-1296. https://doi.org/10.1177/1534735418805560
  9. Lang, J. Y., Feng, M., Luo, Y., Fan, Z., Jiang, Q., Bai, H., et al. (2015). The phase iii clinical study about the effect of kangfuxin solution (chinese herbal medicine compound preparation) on the radiation induced oral and upper gastrointestinal mucositis in nasopharyngeal carcinoma patients. Journal of Clinical Oncology. 33(15_suppl). 6057-6057. https://doi.org/10.1200/jco.2015.33.15_suppl.6057
  10. Shah, S.Rath, H.Sharma, G.Senapati, S. N. & Mishra, E. (2020). Effectiveness of curcumin mouthwash on radiation-induced oral mucositis among head and neck cancer patients: A triple-blind, pilot randomised controlled trial. Indian J Dent Res. 31(5). 718-727. https://doi.org/10.4103/ijdr.IJDR_822_18
  11. Aoyama, T., Nishikawa, K., Takiguchi, N., Tanabe, K., Imano, M., Fukushima, R., et al. (2014). Double-blind, placebo-controlled, randomized phase ii study of tj-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol. 73(5). 1047-1054. https://doi.org/10.1007/s00280-014-2440-x
  12. Hasheminasab, F. S., Hashemi, S. M., Dehghan, A., Sharififar, F., Setayesh, M., Sasanpour, P., et al. (2020). Effects of a plantago ovata-based herbal compound in prevention and treatment of oral mucositis in patients with breast cancer receiving chemotherapy: A double-blind, randomized, controlled crossover trial. Journal of integrative medicine. 18(3). 214-221. https://doi.org/10.1016/j.joim.2020.02.008
  13. Luo, Y., Feng, M., Fan, Z., Zhu, X., Jin, F., Li, R., et al. (2016). Effect of kangfuxin solution on chemo/radiotherapy-induced mucositis in nasopharyngeal carcinoma patients: A multicenter, prospective randomized phase iii clinical study. Evidence-based complementary and alternative medicine : eCAM. 2016 (8692343. https://doi.org/10.1155/2016/8692343
  14. Matsuda, C., Munemoto, Y., Mishima, H., Nagata, N., Oshiro, M., Kataoka, M., et al. (2015). Double-blind, placebo-controlled, randomized phase ii study of tj-14 (hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucositis. Cancer Chemother Pharmacol. 76(1). 97-103. https://doi.org/10.1007/s00280-015-2767-y
  15. Miranzadeh, S. Adib-Hajbaghery, M. Soleymanpoor, L. & Ehsani, M. (2015). Effect of adding the herb achillea millefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial. European journal of oncology nursing : the official journal of European Oncology Nursing Society. 19(3). 207-213. https://doi.org/10.1016/j.ejon.2014.10.019
  16. Moriyama, S., Hinode, D., Yoshioka, M., Sogawa, Y., Nishino, T., Tangoku, A., et al. (2018). Impact of the use of kampo medicine in patients with esophageal cancer during chemotherapy:A clinical trial for oral hygiene and oral condition. J Med Invest. 65(3.4). 184-190. https://doi.org/10.2152/jmi.65.184
  17. Wang, C., Wang, P., Ouyang, H., Wang, J., Sun, L., Li, Y., et al. (2018). Efficacy of traditional chinese medicine in treatment and prophylaxis of radiation-induced oral mucositis in patients receiving radiotherapy: A randomized controlled trial. Integrative cancer therapies. 17(2). 444-450. https://doi.org/10.1177/1534735417725578
  18. Zheng, B., Zhu, X., Liu, M., Yang, Z., Yang, L., Lang, J., et al. (2018). Randomized, double-blind, placebo-controlled trial of shuanghua baihe tablets to prevent oral mucositis in patients with nasopharyngeal cancer undergoing chemoradiation therapy. Int J Radiat Oncol Biol Phys. 100(2). 418-426. https://doi.org/10.1016/j.ijrobp.2017.10.013
  19. Yan Qihui, L. H. Z. W. F. Y. D. J. (2017). Effects of kouyanqing granules on prevention and treatment of radiation-induced oral mucositis patients with head and neck cancer after radiotherapy. China pharmacy. 28(27). 3778-3781. https://doi.org/10.6039/j.issn.1001-0408.2017.27.09
  20. Chong, L. X. W. B.-b. X. D. Z. (2019). Sixty cases of radioactive oral mucositis treated with kouyanning mixture. HENAN TRADITIONAL CHINESE MEDICINE. 39(08). 1243-1246. https://doi.org/10.6039/j.issn.1001-0408.2017.27.09
  21. Gong Yun, C. F.-c., Wang Shao-hua, Zhang Li, He Xu-dong (2016). Clinical observation of kouyanqing granules combined with xipayi mouth rinse in treatment of nasopharyngeal carcinoma radioactive oral mucositis. Drugs & Clinic 31(08). 1249-1252.
  22. Blakaj, A.Bonomi, M.Gamez, M. E. & Blakaj, D. M. (2019). Oral mucositis in head and neck cancer: Evidence-based management and review of clinical trial data. Oral oncology. 95(29-34. https://doi.org/10.1016/j.oraloncology.2019.05.013
  23. Park M-H, P., J-S (2013). Difference of oral mucositis in hospitalized cancer patients receiving chemotherapy. Asian Oncol Nurs. 13(2). 76-84. https://doi.org/10.5388/aon.2013.13.2.76
  24. Lalla, R.Sonis, S. & Peterson, D. (2008). Management of oral mucositis in patients who have cancer. Dent Clin North Am. 52(1). https://doi.org/10.1016/j.cden.2007.10.002
  25. Christophe, L.Marc, A. & Jean-Luc, C. (2006). Oral mucositis induced by anticancer treatments: Physiopathology and treatments. Therapeutics and clinical risk management. 2(2). 159. https://doi.org/10.2147/tcrm.2006.2.2.159
  26. Elsabbagh, H. H.Moussa, E.Mahmoud, S. A. & Elsaka, R. O. (2021). The effectiveness of melatonin in reducing pain resulting from radiation induced oral mucositis: A randomized clinical trial. Alexandria Dental Journal. 46(1). 1-5. https://doi.org/10.1111/odi.13265
  27. Jiang, X.-W., Zhang, Y., Zhu, Y.-L., Zhang, H., Lu, K., Li, F.-F., et al. (2013). Effects of berberine gelatin on recurrent aphthous stomatitis: A randomized, placebo-controlled, double-blind trial in a chinese cohort. Oral surgery, oral medicine, oral pathology and oral radiology. 115(2). 212-217. https://doi.org/10.1016/j.oooo.2012.09.009
  28. Lin Z, Chen J, Han S. The Efficacy of Heat-Clearing (Qingre) and Detoxifying (Jiedu) Traditional Chinese Medicine Gargle for Chemotherapy-Induced Oral Mucositis: A Systematic Review and Meta-Analysis (2021). Frontiers in Pharmacology. 12. https://doi.org/10.3389/fphar.2021.627628
  29. Xie Y, Fang X, Hua H, Zhou P. Efficacy and Safety of Chinese Patent Medicine for the Prevention and Treatment of Radiotherapy and Chemotherapy-Induced Oral Mucositis: A Systematic Review and Meta-Analysis. (2022). Frontiers in Pharmacology. 13. https://doi.org/10.3389/fphar.2022.812085
  30. Huang J, Kan J, Fan T, Quan Q, Li X, Jiang Q, et al. Efficacy of the Nourishing Yin and Clearing Heat Therapy Based on Traditional Chinese Medicine in the Prevention and Treatment of Radiotherapy-Induced Oral Mucositis in Nasopharyngeal Carcinomas: A Systematic Review and Meta-Analysis of Thirty Randomized Controlled Trials. (2022) Evidence-Based Complementary and Alternative Medicine. 2022: 4436361. https://doi.org/10.1155/2022/4436361
  31. Nabil, W. N. N., Lim, R. J., Chan, S. Y., Lai, N. M., Liew, A. C. I. (2018). A systematic review on Chinese herbal treatment for radiotherapy-induced xerostomia in head and neck cancer patients. Complementary therapies in clinical practice, 30, 6-13. https://doi.org/10.1016/j.ctcp.2017.10.004