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Jaundice in Young Children

소아 황달의 영상 평가

  • Young Hun Choi (Department of Radiology, Seoul National University Children's Hospital) ;
  • Seul Bi Lee (Department of Radiology, Seoul National University Children's Hospital) ;
  • Yeon Jin Cho (Department of Radiology, Seoul National University Children's Hospital) ;
  • Seung Hyun Lee (Department of Radiology, Seoul National University Children's Hospital) ;
  • Su-Mi Shin (Department of Radiology, SMG-SNU Boramae Medical Center) ;
  • Jung-Eun Cheon (Department of Radiology, Seoul National University Children's Hospital)
  • 최영훈 (서울대학교 어린이병원 영상의학과) ;
  • 이슬비 (서울대학교 어린이병원 영상의학과) ;
  • 조연진 (서울대학교 어린이병원 영상의학과) ;
  • 이승현 (서울대학교 어린이병원 영상의학과) ;
  • 신수미 (서울특별시 보라매병원 영상의학과) ;
  • 천정은 (서울대학교 어린이병원 영상의학과)
  • Received : 2022.06.09
  • Accepted : 2022.09.13
  • Published : 2022.09.01

Abstract

Jaundice in children have various etiologies. Among them, physiological jaundice is a very common disease observed in more than half of full-term neonates. When jaundice persists or develops after 2 weeks of age, the total/direct bilirubin is measured in consideration of the possibility of cholestasis. In case of cholestasis, imaging studies differentiate biliary atresia and other disorders of the extrahepatic bile ducts. In this review, we briefly presented the major differential diseases of cholestasis in children and introduced diagnostic imaging techniques, including normal findings.

신생아와 유소아 황달은 다양한 원인에 의하여 발생하며, 특히 생리적 황달의 경우는 만삭아의 반수 이상에서 관찰되는 매우 흔한 질환이다. 생후 2주 이후 황달이 지속되거나 새로이 발생하는 경우, 담즙 정체의 가능성을 고려하여 총/직접 빌리루빈을 측정하게 되며, 담즙 정체로 판단되는 경우 외과적 치료를 요하는 간외 담도 폐쇄 질환을 감별하려는 목적으로 영상검사가 의뢰된다. 본 종설에서는 신생아 및 유소아에서 황달을 발생시킬 수 있는 질환들을 분류하고, 질환들을 진단하기 위한 여러 영상 검사들의 종류와 방법 및 정상 소견들을 기술하며, 연령별로 흔히 발생하는 각 질환에 대한 영상 소견들을 소개하고자 한다.

Keywords

References

  1. Ko JS, Seo JK. The etiologies of neonatal cholestasis. Clin Exp Pediatr 2007;50:835-840
  2. Anderson NB, Calkins KL. Neonatal indirect hyperbilirubinemia. Neoreviews 2020;21:e749-e760
  3. Choe BH. Early exclusive diagnosis of biliary atresia among infants with cholestasis. Korean J Pediatr Gastroenterol Nutr 2011;14:122-129
  4. Gubernick JA, Rosenberg HK, Ilaslan H, Kessler A. US approach to jaundice in infants and children. Radiographics 2000;20:173-195
  5. Cho HH, Kim WS, Choi YH, Cheon JE, Lee SM, Kim IO, et al. Ultrasonography evaluation of infants with Alagille syndrome: in comparison with biliary atresia and neonatal hepatitis. Eur J Radiol 2016;85:1045-1052
  6. McGahan JP, Phillips HE, Cox KL. Sonography of the normal pediatric gallbladder and biliary tract. Radiology 1982;144:873-875
  7. Carroll BA, Oppenheimer DA, Muller HH. High-frequency real-time ultrasound of the neonatal biliary system. Radiology 1982;145:437-440
  8. Teele RL, Share JC. Ultrasonography of the biliary tree in infants and children. Appl Radiol 1992;21:15-29
  9. Siegel MJ. Pediatric sonography. 3rd ed. Philadelphia: Lippincott Williams & Wilkins 2002:749
  10. Rosenberg HK, Markowitz RI, Kolberg H, Park C, Hubbard A, Bellah RD. Normal splenic size in infants and children: sonographic measurements. AJR Am J Roentgenol 1991;157:119-121
  11. Norton KI, Glass RB, Kogan D, Lee JS, Emre S, Shneider BL. MR cholangiography in the evaluation of neonatal cholestasis: initial results. Radiology 2002;222:687-691
  12. Sung S, Jeon TY, Yoo SY, Hwang SM, Choi YH, Kim WS, et al. Incremental value of MR cholangiopancreatography in diagnosis of biliary atresia. PLoS One 2016;11:e0158132
  13. Kim JM, Choe BH, Jang YC, Oh KW, Cho MH, Lee KH, et al. Diagnostic limitation and usefulness of 99mTc-DISIDA hepatobiliary scanning on neonatal cholestasis. Clin Exp Pediatr 2006;49:737-744
  14. Nwomeh BC, Caniano DA, Hogan M. Definitive exclusion of biliary atresia in infants with cholestatic jaundice: the role of percutaneous cholecysto-cholangiography. Pediatr Surg Int 2007;23:845-849
  15. Lee SY, Kim GC, Choe BH, Ryeom HK, Jang YJ, Kim HJ, et al. Efficacy of US-guided percutaneous cholecystocholangiography for the early exclusion and type determination of biliary atresia. Radiology 2011;261:916-922
  16. Odievre M, Hadchouel M, Landrieu P, Alagille D, Eliot N. Long-term prognosis for infants with intrahepatic cholestasis and patent extrahepatic biliary tract. Arch Dis Child 1981;56:373-376
  17. Alagille D, Estrada A, Hadchouel M, Gautier M, Odievre M, Dommergues JP. Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr 1987;110:195-200
  18. Oda T, Elkahloun AG, Pike BL, Okajima K, Krantz ID, Genin A, et al. Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nat Genet 1997;16:235-242
  19. Spinner NB, Colliton RP, Crosnier C, Krantz ID, Hadchouel M, Meunier-Rotival M. Jagged1 mutations in alagille syndrome. Hum Mutat 2001;17:18-33
  20. Deprettere A, Portmann B, Mowat AP. Syndromic paucity of the intrahepatic bile ducts: diagnostic difficulty; severe morbidity throughout early childhood. J Pediatr Gastroenterol Nutr 1987;6:865-871
  21. Lee HS, Kim SY, Baek NS, Ha IS, Seo JK. A case of arthrogryposis, renal dysfunction, cholestasis (ARC) syndrome. Korean J Pediatr 1996;39:126-130
  22. Ohura T, Kobayashi K, Tazawa Y, Abukawa D, Sakamoto O, Tsuchiya S, et al. Clinical pictures of 75 patients with neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD). J Inherit Metab Dis 2007;30:139-144
  23. Ko JS, Song JH, Park SS, Seo JK. Neonatal intrahepatic cholestasis caused by citrin deficiency in Korean infants. J Korean Med Sci 2007;22:952-956
  24. Tazawa Y, Kobayashi K, Abukawa D, Nagata I, Maisawa S, Sumazaki R, et al. Clinical heterogeneity of neonatal intrahepatic cholestasis caused by citrin deficiency: case reports from 16 patients. Mol Genet Metab 2004;83:213-219
  25. Khalaf R, Phen C, Karjoo S, Wilsey M. Cholestasis beyond the neonatal and infancy periods. Pediatr Gastroenterol Hepatol Nutr 2016;19:1-11
  26. Friesen CA, Roberts CC. Cholelithiasis. Clinical characteristics in children. Case analysis and literature review. Clin Pediatr (Phila) 1989;28:294-298
  27. Jeong HR, Namkung S, Kim HC, Hong MS. Spontaneous perforation of common bile duct in a child with a clinical manifestation of acute abdominal distension: a case report. J Korean Soc Radiol 2011;65:267-270
  28. Lee MJ, Kim MJ, Yoon CS. MR cholangiopancreatography findings in children with spontaneous bile duct perforation. Pediatr Radiol 2010;40:687-692
  29. Akhan O, Akpinar E, Karcaaltincaba M, Haliloglu M, Akata D, Karaosmanoglu AD, et al. Imaging findings of liver involvement of Wilson's disease. Eur J Radiol 2009;69:147-155
  30. Donnelly LF, Bisset GS 3rd, Frush DP. Diagnosis please. Case 2: embryonal rhabdomyosarcoma of the biliary tree. Radiology 1998;208:621-623