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Malignant Tenosynovial Giant Cell Tumor Presenting as an Extra-Articular Superficial Soft-Tissue Mass in a Knee

무릎에서 관절 외 표재성 연부 종양으로 나타난 악성 건초 거대세포종

  • Received : 2021.04.16
  • Accepted : 2021.10.21
  • Published : 2022.03.01

Abstract

Malignant tenosynovial giant cell tumor (TsGCT) is a rare disease that can arise as a recurrent lesion or co-exist with a benign TsGCT lesion. Here we report a rare case of malignant TsGCT in a 73-year-old male with a history of lymphoma. The tumor appeared as a superficial soft-tissue mass in the subcutaneous fat tissue of the left knee.

악성 건초 거대세포종은 매우 드물며 양성 거대 세포 종양 이후 발생하거나 함께 발생할 수 있다. 저자들은 임파종을 가진 73세 남자 환자에서 왼쪽 무릎의 표재성 연부 종양으로 나타난 드문 악성 거대 세포 종양에 대해 보고한다.

Keywords

Acknowledgement

This work was supported by clinical research grant from Pusan National University Hospital (2020).

References

  1. Kondo R, Akiba J, Hiraoka K, Hisaoka M, Hashimoto H, Kage M, et al. Malignant diffuse-type tenosynovial giant cell tumor of the buttock. Pathol Int 2012;62:559-564
  2. Li CF, Wang JW, Huang WW, Hou CC, Chou SC, Eng HL, et al. Malignant diffuse-type tenosynovial giant cell tumors: a series of 7 cases comparing with 24 benign lesions with review of the literature. Am J Surg Pathol 2008;32:587-599
  3. Jaffe HL, Lichtenstein L, Sutro CJ. Pigmented villonodular synovitis, bursitis and tenosynovitis. Arch Pathol 1941;31:731-765
  4. WHO Classification of Tumours Editorial Board. WHO classification of tumours. Soft tissue and bone tumours. 5th ed. Lyon: IARC Press 2020
  5. Castens HP, Howell RS. Maglignant giant cell tumor of tendon sheath. Virchows Arch A Pathol Anat Histol 1979;382:237-243
  6. Goldblum JR, Folpe AL, Weiss, SW. Benign tumors and tumor-like lesions of synovial tissue. In Weiss SW, Goldblum JR, Folpe AL, eds. Enzinger and Weiss's soft tissue tumors. 6th ed. Philadelphia: Elsevier 2014:766-783
  7. Al-Ibraheemi A, Ahrens WA, Fritchie K, Dong J, Oliveira AM, Balzer B, et al. Malignant tenosynovial giant cell tumor: The true "synovial sarcoma?" A clinicopathologic, immunohistochemical, and molecular cytogenetic study of 10 cases, supporting origin from synoviocytes. Mod Pathol 2019;32:242-251
  8. Nakayama R, Jagannathan JP, Ramaiya N, Ferrone ML, Raut CP, Ready JE, et al. Clinical characteristics and treatment outcomes in six cases of malignant tenosynovial giant cell tumor: initial experience of molecularly targeted therapy. BMC Cancer 2018;18:1296
  9. Murphey MD, Rhee JH, Lewis RB, Fanburg-Smith JC, Flemming DJ, Walker EA. Pigmented villonodular synovitis: radiologic-pathologic correlation. Radiographics 2008;28:1493-1518
  10. Richman DM, Bresler SC, Rosenthal MH, Howard SA. Malignant tenosynovial giant cell tumor of the leg: a radiologic-pathologic correlation and review of the literature. J Clin Imaging Sci 2015;5:13