대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제43권2호
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  • Pages.71-80
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  • 2022
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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유동장내 길이가 다른 두 개의 리간드가 부착된 입자-세포간 상호작용

Interaction between Particle with Dual Ligand and Cell under Flow

  • 윤정현 (연세대학교 미래캠퍼스 의공학부) ;
  • 이세영 (연세대학교 미래캠퍼스 의공학부)
  • Yoon, Jung Hyun (Division of Biomedical Engineering, Yonsei University) ;
  • Lee, Sei Young (Division of Biomedical Engineering, Yonsei University)
  • 투고 : 2021.12.01
  • 심사 : 2022.03.02
  • 발행 : 2022.04.30
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초록

The interaction between dual-ligand decorated particle-based delivery system and target cell under shear flow is predicted using probability model developed. We assumed the two kinds of ligand are decorated on the surface of the particle with 10% length difference. Fixed with other biophysical parameters, a study on the particle-cell interaction for the different non-specific interaction parameter is performed. To induce the firm adhesion, short ligand-receptor should be engaged. Also, it is shown that the rational design of ligand-receptor interaction, including receptor number, specific interaction parameter, kinds of ligand-receptor, etc., should be considered.

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과제정보

이 논문은 2021년도 정부(교육부)의 재원으로 한국연구재단의 지원을 받은 4단계 BK21 사업(Education and Research Center of NBIT-integrated Medical System for Personalized Healthcare-II21SS7606007)의 지원을 받아 수행됨.

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