Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis

  • Maleki, Azam (Social Determinants of Health Research Center, Zanjan University of Medical Sciences) ;
  • Bashirian, Saeid (Social Determinants of Health Research Center, Hamadan University of Medical Sciences) ;
  • Soltanian, Ali Reza (Modeling of Non communicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences) ;
  • Jenabi, Ensiyeh (Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences) ;
  • Farhadinasab, Abdollah (Department of Psychiatry, Shahid Beheshti University of Medical Sciences)
  • 투고 : 2021.02.13
  • 심사 : 2021.03.31
  • 발행 : 2022.02.15
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초록

Background: There is evidence of a relationship between prenatal excess androgen exposure and central nervous developmental problems and attention-deficit/hyperactivity disorder (ADHD) in the offspring of mothers with polycystic ovary syndrome (PCOS). Purpose: Here we aimed to use a meta-analysis to investigate whether the offspring of mothers with PCOS are at an increased chance of developing ADHD. Methods: Three main English databases were searched for articles published through December 2020. The Newcastle-Ottawa Scale was used to assess study quality. Study heterogeneity was determined using I2 statistics and publication bias was assessed using Begg and Egger tests. The results are presented as odds ratio (OR) and relative ratio (RR) estimates with 95% confidence intervals (CIs) using a random-effects model. Results: Six articles (3 cohort and 3 case-control studies; 401,413 total ADHD cases) met the study criteria. Maternal PCOS was associated with an increased risk of ADHD in the offspring based on OR and RR (OR, 1.42; 95% CI, 1.27-1.57) and (RR, 1.43; 95% CI, 1.35-1.51), respectively. There was no heterogeneity among the included articles based on OR (I2=0.0%, P=0.588) and RR (I2=0.0%, P=0.878). Conclusion: Our study showed that maternal PCOS is a risk factor for ADHD. Therefore, screening their offspring for ADHD should be considered part of the comprehensive clinical care of women with PCOS.

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과제정보

This study was funded by Hamadan University of Medical Sciences with code 9911218343. We thank from Hamadan University of Medical Sciences for their support.

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