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Anti-Obesity Effect of Parthenocissus tricuspidata (Siebold & Zucc.) Planch Stem Extracts

소나무 담쟁이덩굴(Parthenocissus tricuspidata (Siebold & Zucc.) Planch) 줄기 추출물의 항비만 효과

  • Yeo, Joo Ho (Department of Medicinal Plant Resources, Andong National University) ;
  • Yu, Ju Hyeong (Department of Medicinal Plant Resources, Andong National University) ;
  • Choi, Min Yeong (Department of Medicinal Plant Resources, Andong National University) ;
  • Lee, Jae Won (Department of Medicinal Plant Resources, Andong National University) ;
  • Geum, Na Gyeong (Department of Medicinal Plant Resources, Andong National University) ;
  • An, Mi-Yun (National Forest Seed and Variety Center) ;
  • Jung, Chuleui (Department of Plant Medicals, Andong National University) ;
  • Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
  • 여주호 (국립안동대학교 생약자원학과) ;
  • 유주형 (국립안동대학교 생약자원학과) ;
  • 최민영 (국립안동대학교 생약자원학과) ;
  • 이재원 (국립안동대학교 생약자원학과) ;
  • 금나경 (국립안동대학교 생약자원학과) ;
  • 안미연 (국립산림품종관리센터) ;
  • 정철의 (국립안동대학교 식물의학과) ;
  • 정진부 (국립안동대학교 생약자원학과)
  • Received : 2022.02.11
  • Accepted : 2022.03.01
  • Published : 2022.04.01

Abstract

In this study, we investigated in vitro anti-obesity activity of Parthenocissus tricuspidata (Siebold & Zucc.) Planch stem (PTS) in mouse adipocytes 3T3-L1 cells. PTS inhibited lipid accumulation and reduced the expression level of the proteins such as C/EBPα, PPARγ and FABP4 associated with adipogenesis in 3T3-L1 cells. In addition, PTS increased lipolysis-related protein expression such as p-AMPK, ATGL and p-HSL, and reduced perilipin-1 in 3T3-L1 cells. Taken together, PTS may have anti-obesity activity through inhibiting adipogenesis and inducing lipid lipolysis in adipocytes. Based on these results, PTS is expected to be used as a potential functional agent for anti-obesity.

본 연구에서 PTS는 지방전구세포에서 PPARγ, C/EBPα 및 FABP4의 발현 억제를 통해 지방전구세포의 adipogenesis를 억제하고, AMPK 및 HSL의 활성화, ATGL의 발현증가, 그리고 perilipin-1의 발현감소를 통해 지방세포의 지질을 분해하여 지방세포 내 과도한 지질형성을 억제하는 것으로 판단된다. 이러한 결과들은 PTS는 비만 예방 및 치료를 위핸잠재적 식의약 소재로의 개발 및 활용이 가능할 것으로 사료된다.

Keywords

Acknowledgement

본 연구는 한국연구재단 이공분야 중점연구소지원사업(NRF-2018R1A6A1A03024862)의 지원에 의해 이루어진 결과로 이에 감사드립니다.

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