Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Sulforaphene Attenuates Cutibacterium acnes-Induced Inflammation

  • Hwan Ju Hwang (WCU Biomodulation Major and Research Institute of Agriculture and Life Sciences,Department of Agricultural Biotechnology, Seoul National University) ;
  • Jong-Eun Kim (Department of Food Science and Technology, Korea National University of Transportation) ;
  • Ki Won Lee (WCU Biomodulation Major and Research Institute of Agriculture and Life Sciences,Department of Agricultural Biotechnology, Seoul National University)
  • Received : 2022.09.30
  • Accepted : 2022.10.18
  • Published : 2022.11.28
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Abstract

Acne is a chronic inflammatory disease of the sebaceous gland attached to the hair follicles. Cutibacterium acnes is a major cause of inflammation caused by acne. It is well known that C. acnes secretes a lipolytic enzyme to break down lipids in sebum, and free fatty acids produced at this time accelerate the inflammatory reaction. There are several drugs used to treat acne; however, each one has various side effects. According to previous studies, sulforaphene (SFEN) has several functions associated with lipid metabolism, brain function, and antibacterial and anti-inflammatory activities. In this study, we examined the effects of SFEN on bacterial growth and inflammatory cytokine production induced by C. acnes. The results revealed that SFEN reduced the growth of C. acnes and inhibited proinflammatory cytokines in C. acnes-treated HaCaT keratinocytes through inhibiting NF-κB-related pathways. In addition, SFEN regulated the expression level of IL-1α, a representative pro-inflammatory cytokine expressed in co-cultured HaCaT keratinocytes and THP-1 monocytes induced by C. acnes. In conclusion, SFEN showed antibacterial activity against C. acnes and controlled the inflammatory response on keratinocytes and monocytes. This finding means that SFEN has potential as both a cosmetic material for acne prevention and a pharmaceutical material for acne treatment.

Keywords

Acknowledgement

This work was supported by the Regional Innovation Strategy (RIS) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (MOE)(2021RIS-001), a Korea Technology and Information Promotion Agency for SMEs (TIPA) grant funded by the Korea government (Ministry of SMEs and Startups) (No. S3174595), National Research Foundation of Korea(NRF) grant funded by the Korea government (MSIT) (2019R1C1C1004387), Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry(IPET) through Technology Commercialization Support Program, funded by Ministry of Agriculture, Food and Rural Affairs(MAFRA)(821027) and the Korea National University of Transportation 2022.

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