Journal of Ginseng Research

  • 제46권1호
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  • Pages.138-146
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  • 2022
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  • 1226-8453(pISSN)
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  • 2093-4947(eISSN)
고려인삼학회 (The Korean Society of Ginseng)
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Rg3-enriched red ginseng extract promotes lung cancer cell apoptosis and mitophagy by ROS production

  • Hwang, Soon-Kyung (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine) ;
  • Jeong, Yun-Jeong (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine) ;
  • Cho, Hyun-Ji (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine) ;
  • Park, Yoon-Yub (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine) ;
  • Song, Kwon-Ho (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine) ;
  • Chang, Young-Chae (Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine)
  • 투고 : 2020.12.09
  • 심사 : 2021.05.12
  • 발행 : 2022.01.01
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초록

Background: Red Ginseng has been used for many years to treat diseases. Ginsenoside Rg3 has documented therapeutic effects, including anticancer and anti-inflammatory activities. However, the anticancer effect of Rg3-enriched red ginseng extract (Rg3-RGE) and its underlying mechanisms have not been fully explored. We investigated whether Rg3-RGE plays an anti-tumor role in lung cancer cells. Methods: To examine the effect of Rg3-RGE on lung cancer cells, we performed cell viability assays, flow cytometry, western blotting analysis, and immunofluorescence to monitor specific markers. Results: Rg3-RGE significantly inhibited cell proliferation and induced mitochondria-dependent apoptosis. Furthermore, Rg3-RGE also increased expression of mitophagy-related proteins such as PINK1 and Parkin. In addition, treatment with Rg3-RGE and mitophagy inhibitors stimulated cell death by inducing mitochondria dysfunction. Conclusions: Rg3-RGE could be used as a therapeutic agent against lung cancer.

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과제정보

This research was supported by the Korean Society of Ginseng (2020).

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