Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지
DOI QR코드

DOI QR Code

Working Memory Impairment in a Delayed Matching-to-Sample Task Among Young Male Patients With Obsessive-Compulsive Disorder

지연 표본 대응 과제에서 나타나는 젊은 남성 강박장애 환자의 작업기억 결손

  • Boo, Young Jun (Graduate school, Yonsei University College of Medicine) ;
  • Park, Jin Young (Department of Psychiatry, Yongin Severance Hospital, Yonsei University Health System) ;
  • Kim, Chan-Hyung (Department of Psychiatry and Institute of Behavioral Science Medicine, Yonsei University College of Medicine) ;
  • Kim, Se Joo (Department of Psychiatry, Yongin Severance Hospital, Yonsei University Health System)
  • 부영준 (연세대학교 의과대학 대학원 의학과) ;
  • 박진영 (용인 세브란스병원 정신건강의학과) ;
  • 김찬형 (연세대학교 의과대학 정신과학교실, 의학행동과학연구소) ;
  • 김세주 (용인 세브란스병원 정신건강의학과)
  • Received : 2022.03.22
  • Accepted : 2022.04.14
  • Published : 2022.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : Impaired working memory has been known to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD) with growing evidence. Delayed matching-to-sample task (DMST) is a working memory task which have an advantage in analyzing several different working memory processes in one task. However, most of the studies have failed to reveal the working memory impairment with the DMST. The aim of this study was to identify whether working memory deficit in OCD can be evaluated with the DMST. Methods : The participants included 20 OCD patients and 20 healthy volunteers. Working memory was evaluated with the DMST with two different working memory loads. Accuracy of response and mean response time were measured. Results : OCD patients showed a significantly longer reaction time and lower accuracy in DMST compared to healthy controls in the task with high working memory loads. Moreover, the difference in accuracy showed interaction with the working memory load. Conclusion : The present results indicate that working memory deficit in patients with OCD can be evaluated with the DMST. The findings also suggest that previous negative behavioral results using the DMST were from low working memory load of the task.

Keywords

Acknowledgement

이 연구는 한국연구재단의 연구비 지원으로 이루어졌음(NRF-2021M3E5D9025022).

References

  1. Stein DJ, Costa DLC, Lochner C, Miguel EC, Reddy YCJ, Shavitt RG, et al. Obsessive-compulsive disorder. Nat Rev Dis Primers 2019;5:52. https://doi.org/10.1038/s41572-019-0102-3
  2. Miller EK, Lundqvist M, Bastos AM. Working Memory 2.0. Neuron 2018;100:463-475. https://doi.org/10.1016/j.neuron.2018.09.023
  3. Chae SH, Shin YC, Shin DW, Oh KS, Jeon SW, Cho SJ. Impairment of working memory in patients with panic disorder. Anxiety and Mood 2021;17:41-47. https://doi.org/10.24986/ANXMOD.2021.17.1.006
  4. Harkin B, Kessler K. The role of working memory in compulsive checking and OCD: a systematic classification of 58 experimental findings. Clin Psychol Rev 2011;31:1004-1021. https://doi.org/10.1016/j.cpr.2011.06.004
  5. Pauls DL, Abramovitch A, Rauch SL, Geller DA. Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci 2014;15:410-424. https://doi.org/10.1038/nrn3746
  6. Menzies L, Chamberlain SR, Laird AR, Thelen SM, Sahakian BJ, Bullmore ET. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 2008;32:525-54 . https://doi.org/10.1016/j.neubiorev.2007.09.005
  7. Nakao T, Okada K, Kanba S. Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin Neurosci 2014;68:587-605. https://doi.org/10.1111/pcn.12195
  8. Konorski J. On the hyperactivity in animals following lesions of the frontal lobes.: USSR Academy of Sciences, Moscow;1957.
  9. Konorski J. A new method of physiological investigation of recent memory in animals. Bull Acad Pol Sci 1959;7:115-117.
  10. Ciesielski KT, Hamalainen MS, Lesnik PG, Geller DA, Ahlfors SP. Increased MEG activation in OCD reflects a compensatory mechanism specific to the phase of a visual working memory task. Neuroimage 2005;24:1180-1191. https://doi.org/10.1016/j.neuroimage.2004.10.018
  11. Purcell R, Maruff P, Kyrios M, Pantelis C. Cognitive deficits in obsessive-compulsive disorder on tests of frontal-striatal function. Biol Psychiatry 1998;43:348-357. https://doi.org/10.1016/S0006-3223(97)00201-1
  12. Ciesielski KT, Hamalainen MS, Geller DA, Wilhelm S, Goldsmith TE, Ahlfors SP. Dissociation between MEG alpha modulation and performance accuracy on visual working memory task in obsessive compulsive disorder. Hum Brain Mapp 2007;28:1401-1414. https://doi.org/10.1002/hbm.20365
  13. Heinzel S, Kaufmann C, Grutzmann R, Klawohn J, Riesel A, Bey K, et al. Polygenic risk for obsessive-compulsive disorder (OCD) predicts brain response during working memory task in OCD, unaffected relatives, and healthy controls. Sci Rep 2021;11:18914. https://doi.org/10.1038/s41598-021-98333-w
  14. Purcell R, Maruff P, Kyrios M, Pantelis C. Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry 1998;55:415-423. https://doi.org/10.1001/archpsyc.55.5.415
  15. Henseler I, Gruber O, Kraft S, Krick C, Reith W, Falkai P. Compensatory hyperactivations as markers of latent working memory dysfunctions in patients with obsessive-compulsive disorder: an fMRI study. J Psychiatry Neurosci 2008;33:209-215.
  16. First MB. User's guide for the structured clinical interview for DSMIV-TR axis I disorders: SCID-I. New York, N.Y.: Biometrics Research Dept., New York State Psychiatric Institute;2002.
  17. Lim JS, Kim SJ, Jeon WT, Cha KR, Park JH, Kim CH. Reliability and validity of the Korean version of Obsessive-Compulsive Inventory-Revised in a non-clinical sample. Yonsei Med J 2008;49:909-916. https://doi.org/10.3349/ymj.2008.49.6.909
  18. Foa EB, Huppert JD, Leiberg S, Langner R, Kichic R, Hajcak G, et al. The Obsessive-Compulsive Inventory: development and validation of a short version. Psychol Assess 2002;14:485-496. https://doi.org/10.1037/1040-3590.14.4.485
  19. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134:382-389. https://doi.org/10.1192/bjp.134.4.382
  20. Ahn YM, Lee KY, Yi JS, Kang MH, Kim DH, Kim JL, et al. A Validation Study of the Korean-Version of the Montgomery-Asberg Depression Rating Scale. J Korean Neuropsychiatr Assoc 2005;44:466-476.
  21. Zimmerman M, Chelminski I, Posternak M. A review of studies of the Montgomery-Asberg Depression Rating Scale in controls: implications for the definition of remission in treatment studies of depression. Int Clin Psychopharmacol 2004;19:1-7. https://doi.org/10.1097/00004850-200401000-00001
  22. Goodman WK, Price LH, Rasmussen SA, Mazure C, Fleischmann RL, Hill CL, et al. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry 1989;46:1006-1011. https://doi.org/10.1001/archpsyc.1989.01810110048007
  23. Storch EA, De Nadai AS, Conceicao do Rosario M, Shavitt RG, Torres AR, Ferrao YA, et al. Defining clinical severity in adults with obsessive-compulsive disorder. Compr Psychiatry 2015;63:30-35. https://doi.org/10.1016/j.comppsych.2015.08.007
  24. Cohen J. Statistical power analysis for the behavioral sciences. New York: NY: Routledge Academic;1988.