The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Immune Enhancing Activity of Neoagarooligosaccharides from Marine Red Algae

홍조류 유래 네오아가로올리고당의 면역 활성 증강 효과

  • Received : 2021.11.22
  • Accepted : 2022.02.08
  • Published : 2022.02.28
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Abstract

Agar, a heterogeneous polymer of galactose, is the main component of the cell wall of marine red algae. It is well established as a safe, non-digestible carbohydrate in oriental countries. Neoagarooligosaccharides (NAOs) prepared by hydrolyzing agar by microbial β-agarase have been reported to show safety. However, their immunological effects have not been reported yet. Thus, the objective of this study was to investigate immune enhancing effects of neoagarooligosaccharides (NAOs) from marine red algae Gelidium elegans in mice by performing ex vivo experiments. Six-week-old mice were fed ad libitum. NAOs were orally administrated at three different concentrations (100, 500, and 2,500 mg/kg B.W./day) twice a week for four weeks. The group fed with NAOs at 2,500 mg/kg showed the highest proliferation of splenocytes and production levels of cytokines (IL-1β, IL-6, TNF-α) in the ex vivo experiment. In conclusion, NAOs can enhance immune function, increase proliferation of splenocytes, and increase cytokine production by activating macrophages in mice.

Keywords

Acknowledgement

본 연구는 2019년도 해양수산부 해양바이오 전략소재 개발 및 상용화 지원-기술상용화지원 사업(20190090)에 의해 수행된 것이며 지원에 감사드립니다.

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