Acknowledgement
This study was supported by the Projects of Innovative Research Groups of the Natural Science Foundation of Hubei Province (No. 2019CFA015), and the National Natural Science Foundation of China (No. 31802076, and No. 31772615), the Open Project of Hubei Key Laboratory of Animal Nutrition and Feed Science (No. 201802).
References
- Wang LM, Tu ZX, Wang HB, et al. Flaxseed oil improves liver injury and inhibits necroptotic and inflammatory signaling pathways following lipopolysaccharide challenge in a piglet model. J Funct Foods 2018;46:482-9. https://doi.org/10.1016/j.jff.2018.05.015
- Chen F, Liu YL, Zhu HL, et al. Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. Innate Immun 2013;19:504-15. https://doi.org/10.1177/1753425912472003
- Tanikawa K, Torimura T. Studies on oxidative stress in liver diseases: important future trends in liver research. Med Mol Morphol 2006;39:22-7. https://doi.org/10.1007/s00795-006-0313-z
- Wu D, Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis 2009;29:141-54. https://doi.org/10.1055/s-0029-1214370
- Borrelli A, Bonelli P, Tuccillo FM, et al. Role of gut microbiota and oxidative stress in the progression of non-alcoholic fatty liver disease to hepatocarcinoma: Current and innovative therapeutic approaches. Redox Biol 2018;15:467-79. https://doi.org/10.1016/j.redox.2018.01.009
- Videla LA. Oxidative stress signaling underlying liver disease and hepatoprotective mechanisms. World J Hepatol 2009;1:72-8. https://doi.org/10.4254/wjh.v1.i1.72
- Ahmad I, Hamid T, Fatima M, et al. Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposure. Biochim Biophys Acta Gen Subj 2000;1523:37-48. https://doi.org/10.1016/S0304-4165(00)00098-2
- Kim YR, Baek JI, Kim SH, et al. Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency. Redox Biol 2019;20:544-55. https://doi.org/10.1016/j.redox.2018.11.013
- Kovacic P, Somanathan R. Mechanism of teratogenesis: electron transfer, reactive oxygen species, and antioxidants. Birth Defects Res C Embryo Today 2006;78:308-25. https://doi.org/10.1002/bdrc.20081
- Sevcikova M, Modra H, Slaninova A, Svobodova Z. Metals as a cause of oxidative stress in fish: a review. Vet Med-Czech 2011;56:537-46. https://doi.org/10.17221/4272-VETMED
- Glusczak L, Miron DDS, Crestani M, et al. Effect of glyphosate herbicide on acetylcholinesterase activity and metabolic and hematological parameters in piava (Leporinus obtusidens). Ecotoxicol Environ Saf 2006;65:237-41. https://doi.org/10.1016/j.ecoenv.2005.07.017
- Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012;149:1060-72. https://doi.org/10.1016/j.cell.2012.03.042
- Wang WW, Wu ZL, Dai ZL, Yang Y, Wang JJ, Wu GY. Glycine metabolism in animals and humans: implications for nutrition and health. Amino Acids 2013;45:463-77. https://doi.org/10.1007/s00726-013-1493-1
- Wu GY. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. J Anim Sci Biotechnol 2014;5:34. https://doi.org/10.1186/2049-1891-5-34
- Wang WW, Dai ZL, Wu ZL, et al. Glycine is a nutritionally essential amino acid for maximal growth of milk-fed young pigs. Amino Acids 2014;46:2037-45. https://doi.org/10.1007/s00726-014-1758-3
- Flynn NE, Knabe DA, Mallick BK, Wu G. Postnatal changes of plasma amino acids in suckling pigs. J Anim Sci 2000;78:2369-75. https://doi.org/10.2527/2000.7892369x
- Barakat H, Hamza AH. Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats. Aust J Basic Appl Sci 2011;5:1061-70.
- Senthilkumar R, Viswanathan P, Nalini N. Effect of glycine on oxidative stress in rats with alcohol induced liver injury. Pharmazie 2004;59:55-60.
- Marsh DC, Vreugdenhil PK, Mack VE, Belzer FO, Southard JH. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Hepatology 1993;17:91-8. https://doi.org/10.1002/hep.1840170117
- Friedmann AJP, Schneider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 2014;16:1180-91. https://doi.org/10.1038/ncb3064
- Lv M, Yu B, Mao XB, Zheng P, He P, Chen DW. Responses of growth performance and tryptophan metabolism to oxidative stress induced by diquat in weaned pigs. Animal 2012;6:928-34. https://doi.org/10.1017/S1751731111002382
- NRC. Nutrient requirements of swine. 11th edn. Washington, DC, USA: National Academic Press; 2012.
- Wu GY, Wu ZL, Dai ZL, et al. Dietary requirements of "nutritionally non-essential amino acids" by animals and humans. Amino Acids 2013;44:1107-13. https://doi.org/10.1007/s00726-012-1444-2
- Cao ST, Wu H, Wang CC, et al. Diquat-induced oxidative stress increases intestinal permeability, impairs mitochondrial function, and triggers mitophagy in piglets. J Anim Sci 2018;96:1795-805. https://doi.org/10.1093/jas/sky104
- Hou YQ, Yao K, Wang L, et al. Effects of α-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysaccharide. Br J Nutr 2011;106:357-63. https://doi.org/10.1017/S0007114511000249
- He PW, Hua HW, Tian W, Zhu HL, Liu YL, Xu X. Holly (Ilex latifolia Thunb.) polyphenols extracts alleviate hepatic damage by regulating ferroptosis following diquat challenge in a piglet model. Front Nutr 2020;7:604328. https://doi.org/10.3389/fnut.2020.604328
- Wang XY, Wang WJ, Wang LM, et al. Lentinan modulates intestinal microbiota and enhances barrier integrity in a piglet model challenged with lipopolysaccharide. Food Funct 2019;10:479-89. https://doi.org/10.1039/c8fo02438c
- Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and 2-ΔΔCT method. Methods 2001;25:402-8. https://doi.org/10.1006/meth.2001.1262
- Van Beek JHDA, de Moor MHM, de Geus EJC, et al. The genetic architecture of liver enzyme levels: GGT, ALT and AST. Behav Genet 2013;43:329-39. https://doi.org/10.1007/s10519-013-9593-y
- Xu FL, You HB, Li XH, Chen XF, Liu ZJ, Gong JP. Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells. Am J Surg 2008;196:139-48. https://doi.org/10.1016/j.amjsurg.2007.09.045
- Froh M, Zhong Z, Walbrun P, et al. Dietary glycine blunts liver injury after bile duct ligation in rats. World J Gastroenterol 2008;14:5996-6003. https://doi.org/10.3748/wjg.14.5996
- Kang P, Liu YL, Zhu HL, et al. The effect of dietary asparagine supplementation on energy metabolism in liver of weaning pigs when challenged with lipopolysaccharide. Asian-Australas J Anim Sci 2018;31:548-55. https://doi.org/10.5713/ajas.17.0426
- Frederich M, O'Rourke MR, Furey NB, Jost JA. AMP-activated protein kinase (AMPK) in the rock crab, Cancer irroratus: an early indicator of temperature stress. J Exp Biol 2009;212:722-30. https://doi.org/10.1242/jeb.021998
- Hardie DG. Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology 2003;144:5179-83. https://doi.org/10.1210/en.2003-0982
- Liu YL, Wang XY, Hu CAA. Therapeutic potential of amino acids in inflammatory bowel disease. Nutrients 2017;9:920. https://doi.org/10.3390/nu9090920
- Hristina K, Langerholc T, Trapecar M. Novel metabolic roles of L-arginine in body energy metabolism and possible clinical applications. J Nutr Health Aging 2014;18:213-8. https://doi.org/10.1007/s12603-014-0015-5
- Pi D, Liu YL, Shi HF, et al. Dietary supplementation of aspartate enhances intestinal integrity and energy status in weanling piglets after lipopolysaccharide challenge. J Nutr Biochem 2014;25:456-62. https://doi.org/10.1016/j.jnutbio.2013.12.006
- Wang Z, Li L, Zheng F, Jia CF, Ruan Y, Li H. Correlation between the amplitude of glucose excursion and the oxidative/antioxidative system in subjects with different types of glucose regulation. Biomed Environ Sci 2011;24:68-73. https://doi.org/10.3967/0895-3988.2011.01.009
- El-Hafidi M, Franco M, Ramirez AR, et al. Glycine increases insulin sensitivity and glutathione biosynthesis and protects against oxidative stress in a model of sucrose-induced insulin resistance. Oxid Med Cell Longev 2018;2018:Article ID 2101562. https://doi.org/10.1155/2018/2101562
- Wang WW, Wu ZL, Lin G, et al. Glycine stimulates protein synthesis and inhibits oxidative stress in pig small intestinal epithelial cells. J Nutr 2014;144:1540-8. https://doi.org/10.3945/jn.114.194001
- Ouyang L, Shi Z, Zhao S, et al. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 2012;45:487-98. https://doi.org/10.1111/j.1365-2184.2012.00845.x
- Cao JY, Dixon SJ. Mechanisms of ferroptosis. Cell Mol Life Sci 2016;73:2195-209. https://doi.org/10.1007/s00018-016-2194-1
- Sutherland R, Delia D, Schneider C, Newman R, Kemshead J, Greaves M. Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin. Proc Natl Acad Sci USA 1981;78:4515-9. https://doi.org/10.1073/pnas.78.7.4515
- Gao MH, Prashant M, Jiang XJ. Metabolism and iron signaling in ferroptotic cell death. Oncotarget 2015;6:35145-6. https://doi.org/10.18632/oncotarget.5671
- Ma ZH, Zhang H, Lian M, et al. SLC7A11, a component of cysteine/glutamate transporter, is a novel biomarker for the diagnosis and prognosis in laryngeal squamous cell carcinoma. Oncol Rep 2017;38:3019-29. https://doi.org/10.3892/or.2017.5976
- Hambright WS, Fonseca RS, Chen L, Na R, Ran QT. Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. Redox Biol 2017;12:8-17. https://doi.org/10.1016/j.redox.2017.01.021
- Ingold I, Berndt C, Schmitt S, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell 2018;172:409-22. https://doi.org/10.1016/j.cell.2017.11.048