Journal of Animal Reproduction and Biotechnology (한국동물생명공학회지)

The Korean Society of Animal Reproduction and Biotechnology (한국동물생명공학회)
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The theranostic roles of extracellular vesicles in pregnancy disorders

  • Saadeldin, Islam M. (Lab. of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Tanga, Bereket Molla (Lab. of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Bang, Seonggyu (Lab. of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Fang, Xun (Lab. of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Yoon, Ki-Young (Department of Companion Animal, Shingu College) ;
  • Lee, Sanghoon (Lab. of Theriogenology, College of Veterinary Medicine, Chungnam National University) ;
  • Cho, Jongki (Lab. of Theriogenology, College of Veterinary Medicine, Chungnam National University)
  • Received : 2021.11.10
  • Accepted : 2021.12.01
  • Published : 2022.03.31
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Abstract

Extracellular vesicles (EVs) are nanovesicles that carry bioactive cargoes of proteins, lipids, mRNAs, and miRNAs between living cells. Their role in cellular communication has gained the attention of several research reports globally in the last decade. EVs are critically involved in sperm functions, oocyte functions, fertilization, embryonic development, and pregnancy. The review summarizes the state-of-the-art of EVs research in the diagnostic and therapeutic (theranostic) potentials of the EVs during the pregnancy that might provide a solution for gestational disturbances such as implantation failure, maternal health problems, gestational diabetes, and preeclampsia. EVs can be found in all biological fluids of the fetus and the mother and would provide a non-invasive and excellent tool for diagnostic purposes. Moreover, we provide the current efforts in manufacturing and designing targeted therapeutics using synthetic and semi-synthetic nanovesicles mimicking the natural EVs for efficient drug delivery during pregnancy.

Keywords

Acknowledgement

We thank the National Research Foundation of Korea and the Brain Pool program for supporting our project.

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