한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제39권6호
  • /
  • Pages.373-377
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  • 2022
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  • 1598-298X(pISSN)
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  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
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Hemostatic Dysfunction in a Dog with Mammary Gland Carcinoma

  • Rankyung, Jung (College of Veterinary Medicine, Gyeongsang National University) ;
  • Hyeona, Bae (College of Veterinary Medicine, Gyeongsang National University) ;
  • ARom, Cho (College of Veterinary Medicine, Gyeongsang National University) ;
  • Young Ju, Kim (College of Veterinary Medicine, Gyeongsang National University) ;
  • Yeseul, Jun (College of Veterinary Medicine, Gyeongsang National University) ;
  • Minji, Kim (College of Veterinary Medicine, Gyeongsang National University) ;
  • Sumin, Cha (College of Veterinary Medicine, Gyeongsang National University) ;
  • Min-Jeong, Kang (College of Veterinary Medicine, Gyeongsang National University) ;
  • Tae-Sung, Hwang (College of Veterinary Medicine, Gyeongsang National University) ;
  • Hee-Chun, Lee (College of Veterinary Medicine, Gyeongsang National University) ;
  • Kyu-Woan, Cho (College of Veterinary Medicine, Gyeongsang National University) ;
  • Dong-In, Jung (College of Veterinary Medicine, Gyeongsang National University) ;
  • Dae Young, Kim (College of Veterinary Medicine, University of Missouri) ;
  • DoHyeon, Yu (College of Veterinary Medicine, Gyeongsang National University)
  • 투고 : 2022.10.13
  • 심사 : 2022.11.23
  • 발행 : 2022.12.31
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초록

Hypercoagulability is the most common coagulopathy seen in dogs with neoplasia, whereas a hypocoagulable state is relatively rare. A 16-year-old spayed female miniature Schnauzer presented with bilateral epistaxis, bilateral hindlimb swelling, and lameness. Previously, the dog was diagnosed with intermediate grade solid carcinoma after mastectomy, and then showed generalized ecchymoses on the abdomen and bilateral hindlimbs on presentation. Laboratory tests revealed a hypocoagulable state, including thrombocytopenia, hypofibrinogenemia, and delayed prothrombin and activated partial thromboplastin time. Thromboelastography demonstrated a prolonged K time with a decreased alpha angle and low maximal amplitude, reflecting a decrease in clot strength. The hypocoagulable state of disseminated intravascular coagulopathy was speculated based on the presence of an underlying tumor, clinical symptoms, and laboratory results of the hypocoagulable state. This case shows the incidence of hemostatic dysfunction as a paraneoplastic syndrome in a dog with mammary gland carcinoma.

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과제정보

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2017R1D1A1B03034904) (2020R1C1C1008675), and by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through Companion Animal Life Cycle Industry Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (322092-04-1-HD030).

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