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Type 4 Tetralogy of Fallot with Pulmonary Hypertension in an American Shorthair Cat

  • Hyeon-Jin, Kim (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Jihyun, Kim (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Tae Jung, Kim (College of Veterinary Medicine, Chonnam National University) ;
  • Ha-Jung, Kim (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chonnam National University)
  • Received : 2022.09.08
  • Accepted : 2022.11.23
  • Published : 2022.12.31

Abstract

A 2-year-old, spayed female, American shorthair cat presented with acute weight loss, tachypnea, and dyspnea. The cat had grade V holosystolic murmur and systemic hypotension. Echocardiography showed a 9 mm defect in the ventricular septum, left-to-right dominant bi-directional shunt, right ventricular hypertrophy, pulmonary stenosis, pulmonary hypertension, and overriding aorta. The cat was diagnosed with a Tetralogy of Fallot. The cat was treated with furosemide, pimobendan, ramipril, and sildenafil. Treatment reduced pulmonary infiltration, pulmonary vessel enlargement, and main pulmonary artery bulging. However, right-to-left flow increased over time and right ventricular outflow tract velocity was elevated. Currently, the patient has maintained an improved state for 1 year. This case report described a severe inherited feline Tetralogy of Fallot case that was successfully managed for a long time.

Keywords

Acknowledgement

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF), which is funded by the Ministry of Education (NRF-2020R1A2C2005364).

References

  1. An HS, Kim GB, Song MK, Bang JS, Lee SY, Bae EJ, et al. Eisenmenger syndrome in adults: treatment pattern and prognostic factors in the advanced pulmonary vasodilator era. Pediatr Cardiol 2019; 40: 23-28.  https://doi.org/10.1007/s00246-018-1956-y
  2. Beghetti M, Galie N. Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. J Am Coll Cardiol 2009; 53: 733-740.  https://doi.org/10.1016/j.jacc.2008.11.025
  3. Berman EB, Barst RJ. Eisenmenger's syndrome: current management. Prog Cardiovasc Dis 2002; 45: 129-138.  https://doi.org/10.1053/pcad.2002.127492
  4. Bonagura JD, Lehmkuhl LB. Congenital heart disease. In: Fox PR, Sisson D, Moise NS, eds. Textbook of canine and feline cardiology: principles and clinical practice. Philadelphia: Saunders. 1999: 471-535. 
  5. Chau EM, Fan KY, Chow WH. Effects of chronic sildenafil in patients with Eisenmenger syndrome versus idiopathic pulmonary arterial hypertension. Int J Cardiol 2007; 120: 301-305.  https://doi.org/10.1016/j.ijcard.2006.10.018
  6. Chetboul V, Pitsch I, Tissier R, Gouni V, Misbach C, Trehiou-Sechi E, et al. Epidemiological, clinical, and echocardiographic features and survival times of dogs and cats with tetralogy of Fallot: 31 cases (2003-2014). J Am Vet Med Assoc 2016; 249: 909-917.  https://doi.org/10.2460/javma.249.8.909
  7. Chow KS, Beijerink NJ, Ettinger S, Fliegner R, Beatty JA, Barrs VR. Use of sildenafil citrate in a cat with Eisenmenger's syndrome and an atrial septal defect. JFMS Open Rep 2015; 1: 2055116915579680.  https://doi.org/10.1177/2055116915579680
  8. Church DB, Allan GS. Atrial septal defect and Eisenmenger's syndrome in a mature cat. Aust Vet J 1990; 67: 380. 
  9. Chuzel T, Bublot I, Couturier L, Nicolier A, Rivier P, Mai W, et al. Persistent truncus arteriosus in a cat. J Vet Cardiol 2007; 9: 43-46.  https://doi.org/10.1016/j.jvc.2005.06.001
  10. Daliento L, Somerville J, Presbitero P, Menti L, Brach-Prever S, Rizzoli G, et al. Eisenmenger syndrome. Factors relating to deterioration and death. Eur Heart J 1998; 19: 1845-1855.  https://doi.org/10.1053/euhj.1998.1046
  11. Hassani K, Jafarian K, Doyle DJ. Heart sounds features usage for classification of ventricular septal defect size in children. In: The 16th International Conference on Biomedical Engineering. Singapore: Springer, 2017: 28-31. 
  12. Hornberger LK, Sahn DJ, Krabill KA, Sherman FS, Swensson RE, Pesonen E, et al. Elucidation of the natural history of ventricular septal defects by serial Doppler color flow mapping studies. J Am Coll Cardiol 1989; 13: 1111-1118.  https://doi.org/10.1016/0735-1097(89)90270-2
  13. Ivy DD, Abman SH, Barst RJ, Berger RM, Bonnet D, Fleming TR, et al. Pediatric pulmonary hypertension. J Am Coll Cardiol 2013; 62(25 Suppl): D117-D126.  https://doi.org/10.1016/j.jacc.2013.10.028
  14. Karsten S, Stephanie S, Vedat Y. Reference intervals and allometric scaling of two-dimensional echocardiographic measurements in 150 healthy cats. J Vet Med Sci 2017; 79: 1764-1771.  https://doi.org/10.1292/jvms.17-0250
  15. Lee SG, Moon HS, Choi R, Hyun C. Ventricular septal defect in an Abyssinian cat. Korean J Vet Res 2008; 48: 99-103. 
  16. Liu SK. Pathology of feline heart diseases. Vet Clin North Am 1977; 7: 323-339.  https://doi.org/10.1016/s0091-0279(77)50033-0
  17. McCord MC, Van Elk J, Blount SG Jr. Tetralogy of Fallot; clinical and hemodynamic spectrum of combined pulmonary stenosis and ventricular septal defect. Circulation 1957; 16: 736-749.  https://doi.org/10.1161/01.CIR.16.5.736
  18. Moise NS, Fox PR. Echocardiography and doppler imaging. In: Fox PR, Sisson D, Moise NS, eds. Textbook of canine and feline cardiology: principles and clinical practice. Philadelphia: Saunders. 1999: 130-171. 
  19. Nakamura K, Yamasaki M, Ohta H, Sasaki N, Murakami M, Bandula Kumara WR, et al. Effects of sildenafil citrate on five dogs with Eisenmenger's syndrome. J Small Anim Pract 2011; 52: 595-598.  https://doi.org/10.1111/j.1748-5827.2011.01127.x
  20. Orton EC, Mama K, Hellyer P, Hackett TB. Open surgical repair of tetralogy of Fallot in dogs. J Am Vet Med Assoc 2001; 219: 1089-1093, 1073.  https://doi.org/10.2460/javma.2001.219.1089
  21. Reinero C, Visser LC, Kellihan HB, Masseau I, Rozanski E, Clercx C, et al. ACVIM consensus statement guidelines for the diagnosis, classification, treatment, and monitoring of pulmonary hypertension in dogs. J Vet Intern Med 2020; 34: 549-573.  https://doi.org/10.1111/jvim.15725
  22. Riesen SC, Kovacevic A, Lombard CW, Amberger C. Prevalence of heart disease in symptomatic cats: an overview from 1998 to 2005. Schweiz Arch Tierheilkd 2007; 149: 65-71.  https://doi.org/10.1024/0036-7281.149.2.65
  23. Simonneau G, Gatzoulis MA, Adatia I, Celermajer D, Denton C, Ghofrani A, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol 2013; 62(25 Suppl): D34-D41. Erratum in: J Am Coll Cardiol 2014; 63: 746. 
  24. Van Praagh R. The first Stella van Praagh memorial lecture: the history and anatomy of tetralogy of Fallot. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2009; 12: 19-38.  https://doi.org/10.1053/j.pcsu.2009.01.004
  25. Visser LC, Sloan CQ, Stern JA. Echocardiographic assessment of right ventricular size and function in cats with hypertrophic cardiomyopathy. J Vet Intern Med 2017; 31: 668-677.  https://doi.org/10.1111/jvim.14688
  26. Vongpatanasin W, Brickner ME, Hillis LD, Lange RA. The Eisenmenger syndrome in adults. Ann Intern Med 1998; 128: 745-755.  https://doi.org/10.7326/0003-4819-128-9-199805010-00008
  27. Wessel A, Buchhorn R, Bursch J. [Circulatory failure in children with left-to-right shunt in the framework of congenital heart defects: pathophysiology and therapeutic results]. Klin Padiatr 2000; 212: 53-59. German.  https://doi.org/10.1055/s-2000-9652
  28. Wood P. The Eisenmenger syndrome or pulmonary hypertension with reversed central shunt. I. Br Med J 1958; 2: 701-709.  https://doi.org/10.1136/bmj.2.5098.701
  29. Yasuhara J, Yamagishi H. Pulmonary arterial hypertension associated with tetralogy of Fallot. Int Heart J 2015; 56 Suppl: S17-S21. https://doi.org/10.1536/ihj.14-351