Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Analysis of inflammatory markers in blood related with the occurrence of subcutaneous abscesses in goats

염소의 피하농양 발생에 따른 혈액 내 염증지표 분석

  • Ku, Ji-yeong (College of Veterinary Medicine, Jeonbuk National University) ;
  • Park, Jun-Hwan (College of Veterinary Medicine, Jeonbuk National University) ;
  • Kim, Seo-Ho (Department of Animal Science and Technology, Sunchon National University) ;
  • Cho, Yong-il (Department of Animal Science and Technology, Sunchon National University) ;
  • Kim, Chan-Lan (Animal Genetic Resources Research Center, National Institute of Animal Science) ;
  • Cha, Seung-Eon (College of Veterinary Medicine, Jeonbuk National University) ;
  • Shin, Gee-Wook (College of Veterinary Medicine, Jeonbuk National University) ;
  • Park, Jinho (College of Veterinary Medicine, Jeonbuk National University)
  • Received : 2022.02.09
  • Accepted : 2022.02.21
  • Published : 2022.03.30
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Abstract

Subcutaneous abscesses, which occur mainly in goats and sheep, are lymph node abscesses caused by Corynebacterium pseudotuberculosis infection, and are divided into internal, external, and mixed types depending on the type of occurrence. While diagnostic methods for subcutaneous abscesses have been continuously studied, research reports for effective treatment and management of subcutaneous abscesses are inadequate. Therefore, this study was conducted to determine the changes in biometric information related to the inflammatory markers of goats induced by subcutaneous abscesses by infection with C. pseudotuberculosis. For this, hematological tests, analysis of inflammatory indicators, and analysis of serum proteins through electrophoresis separation of goats with healthy goats and goats inoculated with C. pseudotuberculosis to induce subcutaneous abscesses were compared and analyzed by date, and the differences and characteristics were identified periodically. As a result, in goats induced with subcutaneous abscesses, anemia findings related to a rapid decrease in red blood cell (RBC), hematocrit (HCT), and hemoglobin (Hb) were observed, and a significant increase in inflammatory cells expressed in total white blood cell (WBC), neutrophil, and monocytes was observed. And the levels of acute phase protein (APP) such as fibrinogen, haptoglobin, and serum amyloid A (SAA) were observed to increase rapidly immediately after infection. In addition, in the results of electrophoretic analysis of serum proteins, it was observed that the levels of α-globulin and β-globulin were significantly increased in goats with subcutaneous abscesses. That is, when looking at these changes, it was found that the systemic inflammatory response of goats was rapidly induced immediately after infection with the C. pseudotuberculosis pathogen. Through this study, it was possible to identify changes in the biomarkers of goats with subcutaneous abscesses, which had not been reported. Furthermore, these analyzed data are thoughts to be of great help in identifying, treating, and managing the goats of subcutaneous abscesses.

Keywords

Acknowledgement

This work was carried out with the support of "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ014960)" Rural Development Administration, Republic of Korea.

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