Childhood Kidney Diseases

Korean Society of Pediatric Nephrology (대한소아신장학회)
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Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies

  • Ji Hyeon, Lim (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Ji Won, Jung (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Heoun Jeong, Go (Department of Pathology, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Joo Hoon, Lee (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine) ;
  • Young Seo, Park (Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine)
  • Received : 2022.07.04
  • Accepted : 2022.10.18
  • Published : 2022.12.31
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Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis requires prompt diagnosis and treatment, since renal function at the time of diagnosis is significantly associated with renal outcomes. Here, we report two pediatric patients with ANCA-positive glomerulonephritis initially presenting with hematuria, mild proteinuria, and normal renal function. The first patient with a high myeloperoxidase-ANCA titer (>134 IU/mL) was diagnosed with rapidly progressive glomerulonephritis based on renal biopsy and treated with immunosuppressive therapy after 10 months of follow-up. The second patient with a low myeloperoxidase-ANCA titer (11 IU/mL) maintained normal kidney function without medication. Two cases showed different clinical course according to ANCA titer.

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References

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