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Cutaneous metastasis of mammary gland tumor in a dog: a case report

  • Choi, Hyejoon (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Kyungpook National University) ;
  • Na, Hyemin (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Sang-Kwon (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Kyungpook National University) ;
  • Bae, Seulgi (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Taeho (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Kija (Department of Veterinary Medical Imaging, College of Veterinary Medicine, Kyungpook National University)
  • 투고 : 2021.09.06
  • 심사 : 2021.12.28
  • 발행 : 2022.03.31

초록

An 8-year-old spayed female, mixed dog presented multiple, bloody exudative skin lesions on the bilateral flank which spread 1 week after mastectomy for treatment of mammary gland tumor (MGT). Multiple, ill-marginated, irregular, and heterogeneously thickened cutaneous and subcutaneous lesions and enlarged lymph nodes were identified in ultrasound and computed tomography. Histopathological examination confirmed adenocarcinoma with lymphatic invasion presumed to be metastatic MGT. Clinical signs improved after chemotherapy but died after 1 month. This study suggests that cutaneous metastasis be considered for differential diagnosis of cutaneous lesions in dogs with a history of MGT, although skin metastasis from MGT is rare.

키워드

참고문헌

  1. Karin US, Deanna RW, Valentina Z. Tumors of the Mammary Gland. In: David MV, Douglas HT, Julius ML, eds. Withrow & MacEwen's Small Animal Clinical Oncology. 6th ed. pp. 604-625, Saunders Elsevier, St. Louis, 2020.
  2. Novosad CA. Principles of treatment for mammary gland tumors. Clin Tech Small Anim Pract 2003;18:107-109. https://doi.org/10.1053/svms.2003.36625
  3. Sorenmo K. Canine mammary gland tumors. Vet Clin North Am Small Anim Pract 2003;33:573-596. https://doi.org/10.1016/S0195-5616(03)00020-2
  4. Mazari B, Qoku A, Dhaskali L. Study of mammary carcinoma in a dog and its relationship with cutaneus metastasis. Angl J Assoc Inst Engl Lang Am Stud 2018;7:46-52.
  5. Simon D, Schoenrock D, Baumgartner W, Nolte I. Postoperative adjuvant treatment of invasive malignant mammary gland tumors in dogs with doxorubicin and docetaxel. J Vet Intern Med 2006;20:1184-1190. https://doi.org/10.1892/0891-6640(2006)20[1184:PATIMM]2.0.CO;2
  6. Varallo GR, Gelaleti GB, Maschio-Signorini LB, Moschetta MG, Lopes JR, De Nardi AB, Tinucci-Costa M, Rocha RM, De Campos Zuccari DA. Prognostic phenotypic classification for canine mammary tumors. Oncol Lett 2019;18:6545-6553.
  7. Clemente M, Perez-Alenza MD, Pena L. Metastasis of canine inflammatory versus non-inflammatory mammary tumours. J Comp Pathol 2010;143:157-163. https://doi.org/10.1016/j.jcpa.2010.02.002
  8. Di Maria FM, Annoni M, Roccabianca P, Antoniazzi E, Bertazzolo W. Cutaneous metastases of prostatic adenocarcinoma in two dogs. Vet Clin Pathol 2020;49:459-464. https://doi.org/10.1111/vcp.12888
  9. Perez Alenza MD, Tabanera E, Pena L. Inflammatory mammary carcinoma in dogs: 33 cases (1995-1999). J Am Vet Med Assoc 2001;219:1110-1114. https://doi.org/10.2460/javma.2001.219.1110
  10. Kim JH, Im KS, Kim NH, Chon SK, Doster AR, Sur JH. Inflammatory mammary carcinoma with metastasis to the brain and distant organs in a spayed Shih Tzu dog. J Vet Diagn Invest 2011;23:1079-1082. https://doi.org/10.1177/1040638711416622
  11. Soultani C, Patsikas MN, Karayannopoulou M, Jakovljevic S, Chryssogonidis I, Papazoglou L, Papaioannou N, Papadopoulou P, Pavlidou K, Ilia GM, Kaitzis DG, Ilia TM. Assessment of sentinel lymph node metastasis in canine mammary gland tumors using computed tomographic indirect lymphography. Vet Radiol Ultrasound 2017;58:186-196. https://doi.org/10.1111/vru.12460
  12. Abdelmegeed SM, Mohammed S. Canine mammary tumors as a model for human disease. Oncol Lett 2018;15:8195-8205.
  13. Soultani C, Patsikas MN, Mayer M, Kazakos GM, Theodoridis TD, Vignoli M, Ilia TSM, Karagiannopoulou M, Ilia GM, Tragoulia I, Angelou VN, Chatzimisios K, Tselepidis S, Papadopoulou PL, Papazoglou LG. Contrast enhanced computed tomography assessment of superficial inguinal lymph node metastasis in canine mammary gland tumors. Vet Radiol Ultrasound 2021;62:557-567. https://doi.org/10.1111/vru.13002
  14. Araujo E, Barbosa M, Costa R, Sousa B, Costa V. A first sign not to be missed: cutaneous metastasis from breast cancer. Eur J Case Rep Intern Med 2020;7:001356.