Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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Effect of Kidney Tonification of Saam Acupuncture in Parkinson's Disease Mouse Model

파킨슨병 동물 모델을 이용한 신정격 사암침법의 도파민성 신경세포 보호 효과 연구

  • Kim, Seungtae (Department of Korean Medical Science, School of Korean Medicine, Pusan National University) ;
  • Lee, Sang-Hyup (Department of Korean Medical Classics, College of Korean Medicine, Dong-eui University) ;
  • Kim, Bo-Kyung (Department of Korean Medical Science, School of Korean Medicine, Pusan National University)
  • 김승태 (부산대학교 한의학전문대학원 한의과학과) ;
  • 이상협 (동의대학교 한의과대학 원전학교실) ;
  • 김보경 (부산대학교 한의학전문대학원 한의과학과)
  • Received : 2022.02.28
  • Accepted : 2022.03.05
  • Published : 2022.03.27
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Abstract

Objectives : Saam acupuncture is one of the indigenous therapeutic modalities in traditional Korean medicine. In this study, the neuroprotective effect of Saam acupuncture of kidney tonification was investigated using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice. Methods : Twelve-week-old male C57BL/6 mice were intraperitoneally administered with 30 mg/kg of MPTP at 24-h intervals for 5 days and acupuncture stimulation at LU8, KI7, SP3 and KI3 was performed once a day for 12 days from the first MPTP injection. The pole test and the rotarod test were performed to evaluate motor function, and dopaminergic neuronal survival in the substantia nigra (SN) and striatum was evaluated using tyrosine-hydroxylase immunohistochemistry. Results : MPTP administration caused behavioral impairment and dopaminergic neuronal death in the nigrostriatal pathway. Whereas the Saam acupuncture treatment alleviated the MPTP-induced motor dysfunction and dopaminergic neuronal death in the SN and striatum. Conclusions : Saam acupuncture of kidney tonification can alleviate the MPTP-induced motor dysfunction and dopaminergic neuronal death in the nigrostriatal pathway, suggesting a possible role for acupuncture in the treatment of Parkinson's disease.

Keywords

Acknowledgement

This work was supported by Pusan National University Research Grant, 2019.

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