대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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간담도 질환에서의 고빌리루빈혈증에 대한 인진호탕의 임상 효과 : 체계적 고찰

Clinical Effect of Injinho-tang on Hyperbilirubinemia in Hepatobiliary Disorders: A Systematic Review

  • 박근준 (부산대학교 한의학전문대학원 한의학과) ;
  • 강희경 (부산대학교한방병원 한방내과) ;
  • 한창우 (부산대학교 한의학전문대학원 한의학과)
  • Keunjoon, Park (Dept. of Korean Medicine, School of Korean Medicine, Pusan National University) ;
  • Heekyung, Kang (Dept. of Internal Medicine, Korean Medicine Hospital of Pusan National University) ;
  • Changwoo, Han (Dept. of Korean Medicine, School of Korean Medicine, Pusan National University)
  • 투고 : 2022.12.01
  • 심사 : 2022.12.23
  • 발행 : 2022.12.30
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초록

Purpose: This systematic review was conducted to evaluate the clinical effects of Injinho-tang on hyperbilirubinemia in hepatobiliary disorders. Methods: We searched for randomized controlled clinical trials that had administered Injinho-tang as an intervention in the following medical databases: Public/Publisher MEDLINE (PubMed), Excerpta Medica dataBASE (EMBASE), Cochrane library, Research Information Sharing Service (RISS), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), and China National Knowledge Infrastructure (CNKI). Among the retrieved studies, only trials that met the inclusion criteria were selected, and serum total bilirubin values were extracted and analyzed from the finally selected trials. Results: The serum total bilirubin values of 1,302 patients with various hepatobiliary diseases were synthesized through a meta-analysis, which confirmed a decrease in serum total bilirubin of 21.03 𝜇mol/L (95% CI -29.58~-12.49, p<0.01) in the group administered with Injinho-tang compared with the control group. Conclusions: Injinho-tang is effective in alleviating hyperbilirubinemia in hepatobiliary diseases when administered with conventional treatment. However, the potential risk of bias, high heterogeneity among the included trials, and differences in herbal composition are limitations of the results of this meta-analysis.

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과제정보

이 과제는 부산대학교 기본연구지원사업(2년)에 의하여 연구되었음.

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