The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Cancer Research Trends in Traditional Korean Medical Journals since 2000 - Topic Modeling Using Latent Dirichlet Allocation and Keyword Network Analysis

2000년 이후 국내 한의학 암 관련 연구 동향 분석 - Latent Dirichlet Allocation 기반 토픽 모델링 및 연관어 네트워크 분석

  • Kyeore, Bae (National Agency for Development of Innovative Technologies in Korean Medicine, National Institute for Korean Medicine Development (NIKOM))
  • 배겨레 (한국한의약진흥원 한의약혁신기술개발사업단)
  • Received : 2022.10.14
  • Accepted : 2022.12.22
  • Published : 2022.12.30
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Abstract

Objectives: The aim of this study is to analyze cancer research trends in traditional Korean medical journals indexed in the Korea Citation Index since 2000. Methods: Cancer research papers published in traditional Korean medical journals were searched in databases from inception to October 2022. The numbers of publications by journal and by year were descriptively assessed. After natural language processing, topic modeling (based on Latent Dirichlet allocation) and keyword network analysis were conducted. Results: This research trend analysis involved 1,265 papers. Six topics were identified by topic modeling: case reports on symptom management, literature reviews, experiments on apoptosis, herbal extract treatments of breast carcinoma cell lines, anti-proliferative effects of herbal extracts, and anti-tumor effects. Keyword network analysis found that the effects of herbal medicine were assessed in clinical and experimental studies, while acupuncture was mainly mentioned in clinical reports. Conclusions: Cancer research papers in traditional Korean medical journals have contributed to evidence-based medicine. Further experimental studies are needed to elucidate the effects of on different hallmarks of cancer. Rigorous clinical studies are needed to support clinical guidelines.

Keywords

Acknowledgement

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술연구개발사업 지원에 의하여 이루어진 것입니다(과제고유번호: HI20C0867).

References

  1. Korea Central Cancer Registry. National Cancer Center. Annual report of cancer statistics in Korea in 2019. 2021.
  2. Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M. How Many Cancer Patients Use Complementary and Alternative Medicine: A Systematic Review and Metaanalysis. Integr Cancer Ther 2012;11(3):187-203.
  3. Oh B, Eade T, Kneebone A, Pavlakis N, Clarke S, Eslick G, et al. Factors Affecting Whether Or Not Cancer Patients Consider Using Acupuncture. Acupuncture in Medicine 2017;35(2):107-13. https://doi.org/10.1136/acupmed-2016-011115
  4. Kwon JH, Lee SC, Lee MA, Kim YJ, Kang JH, Kim JH, et al. Behaviors and Attitudes toward the Use of Complementary and Alternative Medicine among Korean Cancer Patients. Cancer Res Treat 2019;51(3):851-60. https://doi.org/10.4143/crt.2019.137
  5. Hwang JH, Kim WY, Ahmed M, Choi S, Kim J, Han DW. The Use of Complementary and Alternative Medicine by Korean Breast Cancer Women: Is It Associated with Severity of Symptoms? Evid Based Complement Alternat Med 2015;2015:182475.
  6. Mao JJ, Ismaila N, Bao T, Barton D, Ben-Arye E, Garland EL, et al. Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline. J Clin Oncol 2022;40(34):3998-4024. https://doi.org/10.1200/JCO.22.01357
  7. National Comprehensive Cancer Network. Adult Cancer Pain (Version 2.2022); 2022 [Available from: https://www.nccn.org/professionals/physician_gls /pdf/pain.pdf] accessed October 12, 2022.
  8. National Comprehensive Cancer Network. Antiemesis (Version 2.2022); 2022 [Available from: https://www.nccn.org/professionals/physician_gls/pdf/antiemesis.pdf]. accessed October 12, 2022.
  9. National Comprehensive Cancer Network. Cancer -Related Fatigue (Version 2.2022); 2022 [Available from: https://www.nccn.org/professionals/physician_gls/pdf/fatigue.pdf accessed October 12, 2022.
  10. Park BK, Lee JH, Cho CK, Shin HK, Eom SK, Yoo HS. Systemic Review of Clinical Studies about Oriental Medical Treatment of Cancer in Korea. J Int Korean Med 2008; 29(4):1061-74.
  11. Choi JW, Nam YK, Lee JH, Woo HJ. Review of Clinical Study over the Last 10 Years on Korean Medicine Treatment for Cancer: Focusing on Korean Database. J Korean Med Rehab 2021;31(4):75-86.
  12. Oh SY, Shen L, Joo JC, Park SJ. A Literature Review of Clinical Studies on Pharmacopuncture for Cancer Pain through Korean Database Search. J of Kor Traditional Oncology 2020;25(2):1-11. https://doi.org/10.15432/JKTO.2020.25.2.001
  13. Kim SK, Jang SY. A Study on the Research Trends in Domestic Industrial and Management Engineering using Topic Modeling. Journal of the Korea Management Engineers Society 2016; 21(3):71-95.
  14. Hwang JN, Pang JS. An Analysis of Domestic and International Research Trends of Mathematical Reasoning through Topic Modeling. The journal of educational research in mathematics 2020; 30(4):625-48.
  15. Son CY, Song YW, Lee SH. A Study on the Analysis of Korean Medical Services using Latent Dirichlet Allocation Topic Modeling : Focusing on online reviews by medical consumers. Journal of Society of Preventive Korean Medicine 2022;26(1):43-57.
  16. Hirschberg J, Manning CD. Advances in natural language processing. Science 2015;349(6245):261-6. https://doi.org/10.1126/science.aaa8685
  17. Blei DM, Ng AY, Jordan MI. Latent dirichlet allocation. J Mach Learn Res 2003;3(Jan):993-1022.
  18. Ko SG. Trends of Molecular Biology Using Herbs in Cancer Research. J Physiol & Pathol Korean Med 2004;18(6):1752-61.
  19. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144(5):646-74. https://doi.org/10.1016/j.cell.2011.02.013
  20. Aubrey BJ, Kelly GL, Janic A, Herold MJ, Strasser A. How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression? Cell Death Differ 2018;25(1):104-13. https://doi.org/10.1038/cdd.2017.169
  21. Hanahan D, Weinberg RA. The Hallmarks of Cancer. Cell 2000;100(1):57-70. https://doi.org/10.1016/S0092-8674(00)81683-9
  22. Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov 2022;12(1):31-46. https://doi.org/10.1158/2159-8290.CD-21-1059
  23. Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol 2015;35 Suppl(Suppl):S276-S304. https://doi.org/10.1016/j.semcancer.2015.09.007
  24. Kim JH, Park DS, Kim YS, Lee JD. Review on Clinical Study of Oriental Medical Treatment for Cancer in Korea. J Acupunct Res 2012; 29(3):19-28.
  25. Korea Disease Control and Prevention Agency. The Clinical Research Information Service (CRIS) [Available from: https://cris.nih.go.kr] accessed October 13, 2022.
  26. Guyatt GH, Oxman AD, Montori V, Vist G, Kunz R, Brozek J, et al. GRADE guidelines: 5. Rating the quality of evidence--publication bias. J Clin Epidemiol 2011;64(12):1277-82. https://doi.org/10.1016/j.jclinepi.2011.01.011
  27. Jeong JS, Ryu BH, Kim JS, Park JW, Choi WC, Yon SW. Bojungikki-Tang for Cancer-Related Fatigue: A Pilot Randomized Clinical Trial. Integr Cancer Ther 2010;9(4):331-8. https://doi.org/10.1177/1534735410383170
  28. Ko MH, Song SY, Ha SJ, Lee JY, Yoon SW, Park JH, et al. Efficacy and Safety of Yukgunja -Tang for Patients with Cancer-related Anorexia: A Randomized, Controlled Trial, Pilot Study. Integr Cancer Ther 2021;20:15347354211019107.
  29. Park HS, Lee DE, Ha JS, Seo HS, Kim JW. Bibliometric Analysis of the Effect of Acupuncture on Cancer Pain in the Last 20 Years. J Int Korean Med 2021;42(3):279-92.