The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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A Review of Clinical Studies for Chinese Medicine Treatment of Idiopathic Thrombocytopenic Purpura Using the CNKI Database

특발성 혈소판 감소성 자반증의 중의치료에 대한 임상연구 동향 - CNKI검색을 중심으로

  • Ji-eun, Bae (Dept. of Korean Internal Medicine, Daejeon Jaseng Hospital of Korean Medicine) ;
  • Jae-won, Park (Dept. of Korean Internal Medicine, Daejeon Jaseng Hospital of Korean Medicine) ;
  • Jun-kyu, Lim (Dept. of Korean Internal Medicine, Daejeon Jaseng Hospital of Korean Medicine) ;
  • Mi-so, Park (Dept. of Oriental Internal Medicine, Bu-Cheon Jaseng Hospital of Oriental Medicine) ;
  • Jeong-su, Hong (Dept. of Korean Internal Medicine, Daejeon Jaseng Hospital of Korean Medicine) ;
  • Dong-jin, Kim (Dept. of Korean Internal Medicine, Daejeon Jaseng Hospital of Korean Medicine)
  • 배지은 (대전자생한방병원 한방내과) ;
  • 박재원 (대전자생한방병원 한방내과) ;
  • 임준규 (대전자생한방병원 한방내과) ;
  • 박미소 (부천자생한방병원 한방내과) ;
  • 홍정수 (대전자생한방병원 한방내과) ;
  • 김동진 (대전자생한방병원 한방내과)
  • Received : 2022.11.07
  • Accepted : 2022.11.24
  • Published : 2022.12.30
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Abstract

Objectives: The aim of this study was to analyze the latest clinical studies on Korean medicine treatment of idiopathic thrombocytopenic purpura (ITP) in the Chinese National Knowledge Infrastructure (CNKI) database. Methods: We searched the last 6 years of clinical studies discussing Oriental medicine-based treatments for ITP in the CNKI database. A meta-analysis of 13 RCTs was performed by synthesizing the outcomes, including the measured platelet count and total effective rate. The quality of the studies was assessed using Cochrane's risk of bias (RoB) tool. RevMan 5.4.1 software was used for data analysis. Results: Of the 15 selected studies, 1 was a non-randomized controlled trial (nRCT), 2 were case series, and 12 were randomized controlled trials (RCTs). Treatments in all studies included oral herbal medicine. The most frequently used herbal decoction was the Liangxue Jiedu prescription (凉血解毒方), and the most commonly used herb was Agrimonia pilosa (仙鶴草), Astragali Radix (黃芪), Fossilia Glycyrrhizae Radix et Rhizoma (甘草), and Rehmannia glutinosa Liboschitz ex Steudel (地黃). The meta-analysis showed significantly better improvement in platelet counts and total effective rate for ITP in the treatment group than in the control group. Conclusion: Treatment with herbal medicine was effective in treating ITP. However, the significance of this conclusion is somewhat limited due to the low quality of the available studies. Multifaceted and scientifically designed clinical studies are required to develop treatments for ITP based on Korean medicine. The results of this study could be used as basic data for further ITP studies.

Keywords

References

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