Korean journal of applied entomology (한국응용곤충학회지)

Korean Society of Applied Entomology (한국응용곤충학회)
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Physiological Function of Insulin-like Peptides in Insects

곤충 insulin-like peptide의 생리 조절 작용

  • Kim, Doo Kyung (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)) ;
  • Lee, Jaemin (Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST))
  • 김두경 (대구경북과학기술원 뉴바이올로지학과) ;
  • 이재민 (대구경북과학기술원 뉴바이올로지학과)
  • Received : 2022.01.24
  • Accepted : 2022.02.22
  • Published : 2022.03.01
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Abstract

Insulin and insulin-like growth factor-1 (IGF-1) are hormones that play an important role in the physiological regulation of metabolism, growth, and longevity in vertebrates. Likewise, insulin-like peptides (ILPs), which are structurally similar to insulin and IGF-1, are crucial in insect physiology. In this review, we present an integrated summary of insect ILPs and their receptor signaling, which has been shown to be comparable to insulin and IGF-1 receptor signaling in vertebrates based on genetic studies of Drosophila melanogaster. Additionally, we review the control of ILP synthesis and secretion in the brain in response to nutrition, as well as the ILPs' physiological role in insect metabolism. Moreover, we discuss the contribution of ILPs to growth, development, reproduction, and diapause. Finally, we consider the possibility of targeting ILP receptor signaling in pest management.

인슐린(insulin)과 insulin-like growth factor-1 (IGF-1)은 척추동물에서 대사, 생장, 수명 등의 여러 생리대사를 조절하는 중요한 호르몬이다. 곤충에서도 IGF-1과 구조적으로 유사한 insulin-like peptide (ILP)들이 존재하며 이들이 곤충 생리 조절에 중요하게 관여함이 밝혀졌다. 이번 총설에서 곤충 ILP 및 초파리(Drosophila melanogaster) 유전체 분석을 통해 척추동물에 존재하는 인슐린 및 IGF-1 수용체 신호전달계와 유사하다고 확인된 ILP 수용체 신호전달계에 대해 설명하고자 한다. 추가적으로, 곤충 체내의 영양 상태에 따라 조절되는 뇌에서의 ILP의 합성과 분비, ILP에 의한 대사의 생리적 조절에 대해 논한다. 또한 ILP가 생장, 발달, 생식, 휴면에 기여하는 바도 논의하고, 마지막으로 ILP 수용체 신호전달계 제어를 통한 해충 방제에의 이용 가능성에 대해 제안하고자 한다.

Keywords

Acknowledgement

우리나라 곤충생리학과 화학생태학 분야의 발전 및 후학 양성에 기여하신 부경생 교수님의 헌신을 기리고, 이번 특별호 발간을 위해 노력해주신 한국응용곤충학회를 비롯한 많은 분들께 감사드립니다.

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