Acknowledgement
This work was supported by Samsung Science and Technology Foundation under Project Number SSTF-BA1301-53, and KAIST Global Singularity Research Program. S.P. was supported by National Research Foundation of Korea (NRF-2021R1I1A1A01060418).
References
- Ahmadlou, M., Houba, J.H., van Vierbergen, J.F., Giannouli, M., Gimenez, G.A., van Weeghel, C., Darbanfouladi, M., Shirazi, M.Y., Dziubek, J., Kacem, M., et al. (2021). A cell type-specific cortico-subcortical brain circuit for investigatory and novelty-seeking behavior. Science 372, eabe9681. https://doi.org/10.1126/science.abe9681
- Chiang, M.C., Nguyen, E.K., Canto-Bustos, M., Papale, A.E., Oswald, A.M.M., and Ross, S.E. (2020). Divergent neural pathways emanating from the lateral parabrachial nucleus mediate distinct components of the pain response. Neuron 106, 927-939.e5. https://doi.org/10.1016/j.neuron.2020.03.014
- Deng, H., Xiao, X., and Wang, Z. (2016). Periaqueductal gray neuronal activities underlie different aspects of defensive behaviors. J. Neurosci. 36, 7580-7588. https://doi.org/10.1523/JNEUROSCI.4425-15.2016
- Evans, D.A., Stempel, A.V., Vale, R., Ruehle, S., Lefler, Y., and Branco, T. (2018). A synaptic threshold mechanism for computing escape decisions. Nature 558, 590-594. https://doi.org/10.1038/s41586-018-0244-6
- Han, W., Tellez, L.A., Rangel, M.J., Jr., Motta, S.C., Zhang, X., Perez, I.O., Canteras, N.S., Shammah-Lagnado, S.J., van den Pol, A.N., and de Araujo, I.E. (2017). Integrated control of predatory hunting by the central nucleus of the amygdala. Cell 168, 311-324.e18. https://doi.org/10.1016/j.cell.2016.12.027
- Kennedy, A., Kunwar, P.S., Li, L.Y., Stagkourakis, S., Wagenaar, D.A., and Anderson, D.J. (2020). Stimulus-specific hypothalamic encoding of a persistent defensive state. Nature 586, 730-734. https://doi.org/10.1038/s41586-020-2728-4
- Kim, J., Lee, S., Fang, Y.Y., Shin, A., Park, S., Hashikawa, K., Bhat, S., Kim, D., Sohn, J.W., Lin, D., et al. (2019). Rapid, biphasic CRF neuronal responses encode positive and negative valence. Nat. Neurosci. 22, 576-585. https://doi.org/10.1038/s41593-019-0342-2
- Kunwar, P.S., Zelikowsky, M., Remedios, R., Cai, H., Yilmaz, M., Meister, M., and Anderson, D.J. (2015). Ventromedial hypothalamic neurons control a defensive emotion state. Elife 4, e06633. https://doi.org/10.7554/elife.06633
- Li, Y., Zeng, J., Zhang, J., Yue, C., Zhong, W., Liu, Z., Feng, Q., and Luo, M. (2018). Hypothalamic circuits for predation and evasion. Neuron 97, 911-924.e5. https://doi.org/10.1016/j.neuron.2018.01.005
- Mangieri, L.R., Jiang, Z., Lu, Y., Xu, Y., Cassidy, R.M., Justice, N., Xu, Y., Arenkiel, B.R., and Tong, Q. (2019). Defensive behaviors driven by a hypothalamic-ventral midbrain circuit. eNeuro 6, ENEURO.0156-19.2019.
- McNaughton, N. and Corr, P.J. (2018). Survival circuits and risk assessment. Curr. Opin. Behav. Sci. 24, 14-20. https://doi.org/10.1016/j.cobeha.2018.01.018
- Park, S.G., Jeong, Y.C., Kim, D.G., Lee, M.H., Shin, A., Park, G., Ryoo, J., Hong, J., Bae, S., Kim, C.H., et al. (2018). Medial preoptic circuit induces hunting-like actions to target objects and prey. Nat. Neurosci. 21, 364-372. https://doi.org/10.1038/s41593-018-0072-x
- Reis, F.M., Lee, J.Y., Maesta-Pereira, S., Schuette, P.J., Chakerian, M., Liu, J., La-Vu, M.Q., Tobias, B.C., Ikebara, J.M., Kihara, A.H., et al. (2021). Dorsal periaqueductal gray ensembles represent approach and avoidance states. Elife 10, e64934. https://doi.org/10.7554/eLife.64934
- Rossier, D., La Franca, V., Salemi, T., Natale, S., and Gross, C.T. (2021). A neural circuit for competing approach and defense underlying prey capture. Proc. Natl. Acad. Sci. U. S. A. 118, e2013411118. https://doi.org/10.1073/pnas.2013411118
- Ryoo, J., Park, S., and Kim, D. (2021). An inhibitory medial preoptic circuit mediates innate exploration. Front. Neurosci. 15, 716147. https://doi.org/10.3389/fnins.2021.716147
- Shang, C., Liu, A., Li, D., Xie, Z., Chen, Z., Huang, M., Li, Y., Wang, Y., Shen, W.L., and Cao, P. (2019). A subcortical excitatory circuit for sensory-triggered predatory hunting in mice. Nat. Neurosci. 22, 909-920. https://doi.org/10.1038/s41593-019-0405-4
- Tovote, P., Esposito, M.S., Botta, P., Chaudun, F., Fadok, J.P., Markovic, M., Wolff, S.B., Ramakrishnan, C., Fenno, L., Deisseroth, K., et al. (2016). Midbrain circuits for defensive behaviour. Nature 534, 206-212. https://doi.org/10.1038/nature17996
- Viskaitis, P., Irvine, E.E., Smith, M.A., Choudhury, A.I., Alvarez-Curto, E., Glegola, J.A., Hardy, D.G., Pedroni, S.M., Pessoa, M.R.P., Fernando, A.B., et al. (2017). Modulation of SF1 neuron activity coordinately regulates both feeding behavior and associated emotional states. Cell Rep. 21, 3559-3572. https://doi.org/10.1016/j.celrep.2017.11.089
- Wang, L., Chen, I.Z., and Lin, D. (2015). Collateral pathways from the ventromedial hypothalamus mediate defensive behaviors. Neuron 85, 1344-1358. https://doi.org/10.1016/j.neuron.2014.12.025
- Zhang, G.W., Shen, L., Tao, C., Jung, A.H., Peng, B., Li, Z., Zhang, L.I., and Tao, H.W. (2021). Medial preoptic area antagonistically mediates stress-induced anxiety and parental behavior. Nat. Neurosci. 24, 516-528. https://doi.org/10.1038/s41593-020-00784-3
- Zhang, X. and van den Pol, A.N. (2017). Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation. Science 356, 853-859. https://doi.org/10.1126/science.aam7100
- Zhao, Z.D., Chen, Z., Xiang, X., Hu, M., Xie, H., Jia, X., Cai, F., Cui, Y., Chen, Z., Qian, L., et al. (2019). Zona incerta GABAergic neurons integrate prey-related sensory signals and induce an appetitive drive to promote hunting. Nat. Neurosci. 22, 921-932. https://doi.org/10.1038/s41593-019-0404-5
- Zhou, Z., Liu, X., Chen, S., Zhang, Z., Liu, Y., Montardy, Q., Tang, Y., Wei, P., Liu, N., Li, L., et al. (2019). A VTA GABAergic neural circuit mediates visually evoked innate defensive responses. Neuron 103, 473-488.e6. https://doi.org/10.1016/j.neuron.2019.05.027