과제정보
This study was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (2020M3A9D5A01082439 and 2018R1A5A2025079, to H.Y.G., 2016M3A9D5A01952416 to K.T.N., and Bio & Medical Technology Development Program 2021M3H9A1038083 to K.T.N.).
참고문헌
- Abdelrahman, Z., Li, M., and Wang, X. (2020). Comparative review of SARS-CoV-2, SARS-CoV, MERS-CoV, and influenza A respiratory viruses. Front. Immunol. 11, 552909.
- Badou, A., Basavappa, S., Desai, R., Peng, Y.Q., Matza, D., Mehal, W.Z., Kaczmarek, L.K., Boulpaep, E.L., and Flavell, R.A. (2005). Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science 307, 117-121. https://doi.org/10.1126/science.1100582
- Bao, L., Deng, W., Huang, B., Gao, H., Liu, J., Ren, L., Wei, Q., Yu, P., Xu, Y., Qi, F., et al. (2020). The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature 583, 830-833. https://doi.org/10.1038/s41586-020-2312-y
- Blanco-Melo, D., Nilsson-Payant, B.E., Liu, W.C., Uhl, S., Hoagland, D., Moller, R., Jordan, T.X., Oishi, K., Panis, M., Sachs, D., et al. (2020). Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell 181, 1036-1045.e9. https://doi.org/10.1016/j.cell.2020.04.026
- Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395, 507-513. https://doi.org/10.1016/s0140-6736(20)30211-7
- Cleary, S.J., Pitchford, S.C., Amison, R.T., Carrington, R., Robaina Cabrera, C.L., Magnen, M., Looney, M.R., Gray, E., and Page, C.P. (2020). Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology. Br. J. Pharmacol. 177, 4851-4865. https://doi.org/10.1111/bph.15143
- Cui, J., Li, F., and Shi, Z.L. (2019). Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol. 17, 181-192. https://doi.org/10.1038/s41579-018-0118-9
- de Wit, E., van Doremalen, N., Falzarano, D., and Munster, V.J. (2016). SARS and MERS: recent insights into emerging coronaviruses. Nat. Rev. Microbiol. 14, 523-534. https://doi.org/10.1038/nrmicro.2016.81
- Esposito, S., D'Abrosca, G., Antolak, A., Pedone, P.V., Isernia, C., and Malgieri, G. (2022). Host and viral zinc-finger proteins in COVID-19. Int. J. Mol. Sci. 23, 3711.
- Harrison, A.G., Lin, T., and Wang, P. (2020). Mechanisms of SARS-CoV-2 transmission and pathogenesis. Trends Immunol. 41, 1100-1115. https://doi.org/10.1016/j.it.2020.10.004
- Heister, P.M. and Poston, R.N. (2020). Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19. Pharmacol. Res. Perspect. 8, e00653.
- Israelow, B., Song, E., Mao, T., Lu, P., Meir, A., Liu, F., Alfajaro, M.M., Wei, J., Dong, H., Homer, R.J., et al. (2020). Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. J. Exp. Med. 217, e20201241.
- Jiang, R.D., Liu, M.Q., Chen, Y., Shan, C., Zhou, Y.W., Shen, X.R., Li, Q., Zhang, L., Zhu, Y., Si, H.R., et al. (2020). Pathogenesis of SARS-CoV-2 in transgenic mice expressing human angiotensin-converting enzyme 2. Cell 182, 50-58.e8. https://doi.org/10.1016/j.cell.2020.05.027
- Kirtipal, N., Bharadwaj, S., and Kang, S.G. (2020). From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses. Infect. Genet. Evol. 85, 104502.
- Masters, P.S. (2006). The molecular biology of coronaviruses. Adv. Virus Res. 66, 193-292. https://doi.org/10.1016/S0065-3527(06)66005-3
- McClain, M.T., Constantine, F.J., Henao, R., Liu, Y., Tsalik, E.L., Burke, T.W., Steinbrink, J.M., Petzold, E., Nicholson, B.P., Rolfe, R., et al. (2021). Dysregulated transcriptional responses to SARS-CoV-2 in the periphery. Nat. Commun. 12, 1079.
- McCray, P.B., Jr., Pewe, L., Wohlford-Lenane, C., Hickey, M., Manzel, L., Shi, L., Netland, J., Jia, H.P., Halabi, C., Sigmund, C.D., et al. (2007). Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. J. Virol. 81, 813-821. https://doi.org/10.1128/JVI.02012-06
- Mihelic, M., Teuscher, C., Turk, V., and Turk, D. (2006). Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases. FEBS Lett. 580, 4195-4199. https://doi.org/10.1016/j.febslet.2006.06.076
- Mohamadian, M., Chiti, H., Shoghli, A., Biglari, S., Parsamanesh, N., and Esmaeilzadeh, A. (2021). COVID-19: virology, biology and novel laboratory diagnosis. J. Gene Med. 23, e3303.
- Moreau, G.B., Burgess, S.L., Sturek, J.M., Donlan, A.N., Petri, W.A., and Mann, B.J. (2020). Evaluation of K18-hACE2 mice as a model of SARS-CoV-2 infection. Am. J. Trop. Med. Hyg. 103, 1215-1219. https://doi.org/10.4269/ajtmh.20-0762
- Okeke, E.B. and Uzonna, J.E. (2019). The pivotal role of regulatory T cells in the regulation of innate immune cells. Front. Immunol. 10, 680.
- Oladunni, F.S., Park, J.G., Pino, P.A., Gonzalez, O., Akhter, A., Allue-Guardia, A., Olmo-Fontanez, A., Gautam, S., Garcia-Vilanova, A., Ye, C., et al. (2020). Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice. Nat. Commun. 11, 6122.
- Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A.D., Rawlik, K., Pasko, D., Walker, S., Parkinson, N., Fourman, M.H., Russell, C.D., et al. (2021). Genetic mechanisms of critical illness in COVID-19. Nature 591, 92-98. https://doi.org/10.1038/s41586-020-03065-y
- Park, S.H. (2021). An impaired inflammatory and innate immune response in COVID-19. Mol. Cells 44, 384-391. https://doi.org/10.14348/molcells.2021.0068
- Peiris, J.S., Yuen, K.Y., Osterhaus, A.D., and Stohr, K. (2003). The severe acute respiratory syndrome. N. Engl. J. Med. 349, 2431-2441. https://doi.org/10.1056/NEJMra032498
- Qinfen, Z., Jinming, C., Xiaojun, H., Huanying, Z., Jicheng, H., Ling, F., Kunpeng, L., and Jingqiang, Z. (2004). The life cycle of SARS coronavirus in Vero E6 cells. J. Med. Virol. 73, 332-337. https://doi.org/10.1002/jmv.20095
- Rha, M.S. and Shin, E.C. (2021). Activation or exhaustion of CD8(+) T cells in patients with COVID-19. Cell. Mol. Immunol. 18, 2325-2333. https://doi.org/10.1038/s41423-021-00750-4
- Sturm, G., Finotello, F., and List, M. (2020). Immunedeconv: an R package for unified access to computational methods for estimating immune cell fractions from bulk RNA-sequencing data. Methods Mol. Biol. 2120, 223-232. https://doi.org/10.1007/978-1-0716-0327-7_16
- Tau, G.Z., von der Weid, T., Lu, B., Cowan, S., Kvatyuk, M., Pernis, A., Cattoretti, G., Braunstein, N.S., Coffman, R.L., and Rothman, P.B. (2000). Interferon gamma signaling alters the function of T helper type 1 cells. J. Exp. Med. 192, 977-986. https://doi.org/10.1084/jem.192.7.977
- Walls, A.C., Park, Y.J., Tortorici, M.A., Wall, A., McGuire, A.T., and Veesler, D. (2020). Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell 181, 281-292.e6. https://doi.org/10.1016/j.cell.2020.02.058
- Wan, Y., Shang, J., Graham, R., Baric, R.S., and Li, F. (2020). Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J. Virol. 94, e00127-20.
- Wen, W., Su, W., Tang, H., Le, W., Zhang, X., Zheng, Y., Liu, X., Xie, L., Li, J., Ye, J., et al. (2020). Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Cell Discov. 6, 31.
- Winkler, E.S., Bailey, A.L., Kafai, N.M., Nair, S., McCune, B.T., Yu, J., Fox, J.M., Chen, R.E., Earnest, J.T., Keeler, S.P., et al. (2020). SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function. Nat. Immunol. 21, 1327-1335. https://doi.org/10.1038/s41590-020-0778-2
- Wolfel, R., Corman, V.M., Guggemos, W., Seilmaier, M., Zange, S., Muller, M.A., Niemeyer, D., Jones, T.C., Vollmar, P., Rothe, C., et al. (2020). Virological assessment of hospitalized patients with COVID-2019. Nature 581, 465-469. https://doi.org/10.1038/s41586-020-2196-x
- Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., Hu, Y., Tao, Z.W., Tian, J.H., Pei, Y.Y., et al. (2020). A new coronavirus associated with human respiratory disease in China. Nature 579, 265-269. https://doi.org/10.1038/s41586-020-2008-3
- Xu, X.W., Wu, X.X., Jiang, X.G., Xu, K.J., Ying, L.J., Ma, C.L., Li, S.B., Wang, H.Y., Zhang, S., Gao, H.N., et al. (2020). Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series. BMJ 368, m606.
- Yinda, C.K., Port, J.R., Bushmaker, T., Offei Owusu, I., Purushotham, J.N., Avanzato, V.A., Fischer, R.J., Schulz, J.E., Holbrook, M.G., Hebner, M.J., et al. (2021). K18-hACE2 mice develop respiratory disease resembling severe COVID-19. PLoS Pathog. 17, e1009195.
- Yu, G., Wang, L.G., Han, Y., and He, Q.Y. (2012). clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284-287. https://doi.org/10.1089/omi.2011.0118
- Zhao, M.M., Yang, W.L., Yang, F.Y., Zhang, L., Huang, W.J., Hou, W., Fan, C.F., Jin, R.H., Feng, Y.M., Wang, Y.C., et al. (2021). Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. Signal Transduct. Target. Ther. 6, 134.
- Zheng, X.S., Wang, Q., Min, J., Shen, X.R., Li, Q., Zhao, Q.C., Wang, X., Jiang, R.D., Geng, R., Chen, Y., et al. (2022). Single-cell landscape of lungs reveals key role of neutrophil-mediated immunopathology during lethal SARS-CoV-2 infection. J. Virol. 96, e0003822.
- Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020). A novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 382, 727-733. https://doi.org/10.1056/nejmoa2001017