Journal of the Korean Wood Science and Technology

  • 제50권1호
  • /
  • Pages.12-30
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  • 2022
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  • 1017-0715(pISSN)
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  • 2233-7180(eISSN)
한국목재공학회 (The Korean Society of Wood Science & Technology)
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Synergistic Antifungal Activity of Phellodendri Cortex and Magnoliae Cortex against Candida albicans

  • NA, Hyunjeong (Department of Forest Products and Biotechnology, College of Science and Technology, Kookmin University) ;
  • KIM, Tae-Jong (Department of Forest Products and Biotechnology, College of Science and Technology, Kookmin University)
  • 투고 : 2021.11.19
  • 심사 : 2021.12.28
  • 발행 : 2022.01.25
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초록

Many studies on plant extracts have been reported for the treatment of candidiasis caused by Candida albicans, a representative fungal infection. This study demonstrates the synergistic antifungal activity of the combination of Phellodendri Cortex and Magnoliae Cortex, previously reported to have antifungal efficacy. Considering the antifungal efficacy and the separation of the active constituents, berberine and magnolol, hot water extraction and carbon dioxide supercritical extraction were selected for Phellodendri Cortex and Magnoliae Cortex, respectively. A combination of 0.55 g/L hot water extract of Phellodendri Cortex and 0.59 g/L carbon dioxide supercritical extract of Magnoliae Cortex showed synergistic antifungal activity. The synergistic antifungal activity of 160 μM berberine and 100 μM magnolol, which are representative antifungal compounds of Phellodendri Cortex and Magnoliae Cortex, respectively, contributes to the synergistic antifungal effect of their extracts. The additive decrease in cellular ergosterol level and the increased antifungal efficacy by extracellular ergosterol suggest that disruption of the biological function of ergosterol in the cell membrane is not responsible for the synergistic antifungal activity of berberine and magnolol. Synergistic cellular release of chromosomal DNA upon mixing berberine and magnolol indicates that disruption of the cellular structure is responsible for the synergistic antifungal effect of berberine and magnolol.

키워드

과제정보

This study was carried out with the support of "R&D Program for Forest Science Technology" (Project No. 2019150B10-2123-0301) provided by Korea Forest Service (Korea Forestry Promotion Institute).

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