Journal of the Korea Convergence Society (한국융합학회논문지)

Korea Convergence Society (한국융합학회)
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Convergence research on cytological diagnosis of gynecological diseases and genital HPV : Based on data from the Obstetrics and Gynecology Department of a general hospital located in Suwon-si

수원시 소재 일개 종합병원 산부인과에서 자궁경부 질환 검사의 실태조사 : HPV와 세포학적 검사의 융합연구

  • Joung, You Hyun (Department of Medical Laser, Graduate School of Medicine, Dankook University) ;
  • Lee, Jun Min (Department of Biomedical Laboratory Science, College of Health Sciences, Dankook University) ;
  • Kim, Jong-Wan (Department of Laboratory Medicine, College of Medicine, Dankook University) ;
  • Kim, Jae Kyung (Department of Biomedical Laboratory Science, College of Health Sciences, Dankook University)
  • 정유현 (단국대학교 의학대학원 의학레이저 협동과정) ;
  • 이준민 (단국대학교 보건과학대 임상병리학과) ;
  • 김종완 (단국대학교 의과대학 의학과) ;
  • 김재경 (단국대학교 보건과학대 임상병리학과)
  • Received : 2021.10.19
  • Accepted : 2022.01.20
  • Published : 2022.01.28
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Abstract

Cervical cytology has been widely used as a screening tool for cervical cancer. However, Human papillomavirus (HPV) detection and subtype testing are suggested to overcome the high false-negative rate associated with cytology. We aimed to investigate the clinical usefulness and infection rate in the HPV polymerase chain reaction (PCR) test performed in hospitals. HPV PCR data from 217 patients were analyzed. Analysis of variance revealed a significant difference in the infection rate among different age groups (P=0.015). The biopsy results showed that epithelial cell abnormalities and high HPV-positivity rate was observed in 1 (100%) subject aged <29 years, in 4 out of 5 (80%) patients in their 30s, and in 3 out of 4 (75%) patients aged ≥70 years. The prevalence of HPV infection was very high (46.1%). The highest prevalence (87.5%) was observed among patients in their <29, followed by those in their 30s (67.7%) and those in their 40s (31.9%).A high rate of epithelial cell abnormalities (≥ cervical intraepithelial neoplasia type 1, mild dysplasia) was observed in HPV-infected women aged<30 years. Therefore, extensive research and prevention activities are needed in this age group. HPV PCR testing is recommended to complement cervical cytology

자궁경부세포검사는 자궁경부암 선별검사로 널리 사용되어 왔다. 그러나, 위음성 비율이 높아 인유두종바이러스 중합효소연쇄반응 (HPV PCR) 검사로 보완이 제안되고 있다. HPV PCR 검사의 임상적 유용성을 확인하여, 자궁경부암을 예방하는 선별검사의 효과를 알아보고자 한다. 217명의 환자의 데이터를 분석하였고, 높은 HPV 감염률(46.1%)과 분산분석결과 연령 집단간 HPV 감염률에 유의한 차이가 보였다(P=0.015). 특히, 연구기간 중 CIN3 3건 상피세포암 1건이 관찰되었는데, 고위험군 HPV(16, 33)감염이 모두 관찰되었고, 20대와 30대 상피세포 이형성증 진단 환자에서 높은 고위험군 HPV감염이 관찰되었다. 따라서 이 연령대에 대한 광범위한 연구 및 예방 활동이 필요하며, 자궁암 예방을 위한 선별검사로써 세포학적 검사와 함께 HPV PCR 검사가 유용할 것으로 판단된다.

Keywords

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