Journal of the Korean Magnetic Resonance Society (한국자기공명학회논문지)

Korean Magnetic Resonance Society (한국자기공명학회)
권호 표지
DOI QR코드

DOI QR Code

NMR-based metabolic responses of the zebrafish exposed to Benzo[a]pyrene

  • Sujin, Lee (Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University) ;
  • Seonghye, Kim (Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University) ;
  • Suhkmann, Kim (Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University)
  • Received : 2022.12.12
  • Accepted : 2022.12.20
  • Published : 2022.12.20
Download PDF
⟨ Previous Next ⟩

Abstract

Benzo[a]pyrene (BaP), one of the polycyclic aromatic hydrocarbons (PAHs), is an endocrine disruptor and carcinogenic. This study was conducted to investigate the metabolic changes of zebrafish short-term exposure to BaP using nuclear magnetic resonance (NMR) spectroscopy. In our results, the multivariate analysis showed that the metabolic responses were differed according to the exposure concentration. Also, it was observed that exposure to high concentration of BaP (162 ㎍/L and 1620 ㎍/L) increased the levels of creatine, histidine, and inosine in zebrafish, which means high concentration of BaP exposure affected the energy metabolism and immune function in zebrafish.

Keywords

Acknowledgement

이 작품은 부산대학교 기본연구지원사업(2년)의 지원을 받아 연구되었다.

References

  1. C. J. Gerger and L. P. Weber, Aquat. Toxicol. 165, 19 (2015)
  2. A. L. Knecht, L. Truong, S. W. Marvel, D. M. Reif, A. Garcia, C. Lu, and R. L. Tanguay, Toxicol. Appl. Pharmacol. 329, 148 (2017)
  3. L. Huang, Z. Zuo, Y. Zhang, M. Wu, J. J. Lin, and C. Wang, Chemosphere 108, 55 (2014)
  4. D. Gao, J. Lin, K. Ou, Y. Chen, H. Li, Q. Dai, and C. Wang, Environ. Pollut. 240, 403 (2018)
  5. L. Palanikumar, A. K. Kumaraguru, C. M. Ramakritinan, and M. Anand, Ecotoxicol. Environ. Saf. 75, 187 (2012)
  6. L. Zhang, X. Liu, L. You, D. Zhou, Q. Wang, F. Li, and H. Wu, Environ. Toxicol. Pharmacol. 32, 2, 218 (2011)
  7. H. Chen, X. Diao, H. Wang, and H. Zhou, Ecotoxicol. Environ. Saf. 156, 330 (2018)
  8. I. F. S. Goncalves, T. M. Souza, L. R. Vieira, F. C. Marchi, A. P. Nascimento, and D. F. Farias, Environ. Sci. Pollut. Res. 27, 10, 10185
  9. S. Lee, S. Oh, S. Kim, W. Lee, J. Choi, H. Lee, and S. J. Kim, J. Kor. Magn. Reson. Soc. 24, 4, 104 (2020) 
  10. Y. S. Jung, J. Kor. Magn. Reson. Soc. 21, 3, 96 (2017)