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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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SUMO pathway is required for ribosome biogenesis

  • Hong-Yeoul, Ryu (BK21 FOUR KNU Creative BioResearch Group, School of Life Sciences, College of National Sciences, Kyungpook National University)
  • Received : 2022.07.25
  • Accepted : 2022.09.26
  • Published : 2022.11.30
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Abstract

Ribosomes, acting as the cellular factories for protein production, are essential for all living organisms. Ribosomes are composed of both proteins and RNAs and are established through the coordination of several steps, including transcription, maturation of ribosomal RNA (rRNA), and assembly of ribosomal proteins. In particular, diverse factors required for ribosome biogenesis, such as transcription factors, small nucleolar RNA (snoRNA)-associated proteins, and assembly factors, are tightly regulated by various post-translational modifications. Among these modifications, small ubiquitin-related modifier (SUMO) targets lots of proteins required for gene expression of ribosomal proteins, rRNA, and snoRNAs, rRNA processing, and ribosome assembly. The tight control of SUMOylation affects functions and locations of substrates. This review summarizes current studies and recent progress of SUMOylation-mediated regulation of ribosome biogenesis.

Keywords

Acknowledgement

This study was supported by a National Research Foundation of Korea (NRF) grant funded by the South Korean government (MSIT) (nos. 2020R1C1C1009367 and 2020R1A4A1018280) and Korean Environment Industry & Technology Institute (KEITI) through Core Technology Development Project for Environmental Diseases Prevention and Management funded by Korean Ministry of Environment (MOE) (no. 2022003310001).

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