한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제35권6호
  • /
  • Pages.513-520
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  • 2022
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  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
권호 표지
DOI QR코드

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블루베리와 아로니아를 함유한 청국장 환 제품의 마우스 염증성 장질환 개선 효과

Effect of Cheonggukjang Pills Product Containing Blueberry and Aronia in Mouse Inflammatory Bowel Disease

  • 김하림 ((재)전주농생명소재연구원) ;
  • 노은미 ((재)전주농생명소재연구원) ;
  • 이승현 ((재)전주농생명소재연구원) ;
  • 조종현 (순창문옥례식품(주)) ;
  • 박미희 ((재)전주농생명소재연구원) ;
  • 김선영 ((재)전주농생명소재연구원)
  • 투고 : 2022.11.04
  • 심사 : 2022.12.08
  • 발행 : 2022.12.31
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초록

The purpose of this study was to investigate the effect of Cheonggukjang pills with aronia and blueberries on dextran sulfate sodium (DSS)-induced colitis in mice. There have been several reports that Cheonggukjang is effective for intestinal health, but the efficacy of Cheonggukjang containing fruits has not yet been reported. In this study, we showed the effect of cheonggukjang pills with blueberries and aronia (CPBA) on DSS-induced colitis in BALB/c mice. CPBA was obtained from Soonchang Moonokae foods and orally administered once a day for 2 weeks before DSS treatment. Colitis was induced in mice by feeding 5% (w/v) DSS drinking water for 7 days. The results showed that CPBA treatment significantly alleviated DSS-induced disease activity index associated with a decrease in colon length. CPBA improved DSS-induced histological changes and intestinal epithelial barrier integrity in mice colon. In addition, CPBA administration significantly reduced the levels of DSS-mediated interferon-γ and interleukin-6 in serum and tumor necrosis factor-α in colon tissue. Moreover, the gene expression of COX-2 and iNOS, which are factors involved in inflammatory signaling, was significantly reduced by CPBA treatment. These results suggest that CPBA have a protective effect against DSS-induced mice colitis and may be a candidate for colitis treatment.

키워드

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