전자통신동향분석 (Electronics and Telecommunications Trends)

한국전자통신연구원 (Electronics and Telecommunications Research Institute)
권호 표지
DOI QR코드

DOI QR Code

근적외선 펨토초 레이저 및 이광자 바이오 영상 기술

Near Infrared Femtosecond Laser and Its Two-photon Bio-imaging Technology

  • 발행 : 2021.10.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Over the last three decades, the development of Ti:sapphire femtosecond lasers has led to advancements in scientific and industrial fields. In particular, these advanced lasers show great potential for applications with bio-imaging and medical surgery, such as two-photon microscopy, nonlinear Raman microscopy, optical coherence tomography, and ophthalmic surgery. Herein, we present a detailed description of the theoretical and experimental physics of Kerr-lens mode-locked femtosecond Ti:sapphire lasers and its two-photon microscopy.

키워드

과제정보

본 연구 논문은 한국전자통신연구원 내부연구과제(전략기술)의 일환으로 수행되었음[21YR1800, ICT기반 차세대 의료 핵심기술 개발 & 21YR2400, 뇌 및 척수 질환 환자 대상 치료와 합병증 예측을 위한 영상 및 의료지능 핵심기술 개발].

참고문헌

  1. C.V. Shank et al., "Subpicosecond kilowatt pulses from a mode-locked cw dye laser," Appl. Phys. Lett. vol. 24, no. 8, 1974. https://doi.org/10.1063/1.1655223
  2. T.R. Schibli et al., "Toward single-cycle laser system," IEEE J. Quant. Electron. vol. 9, no. 4, 2003, pp. 990-1001. https://doi.org/10.1109/JSTQE.2003.819108
  3. D.E. Spence et al., "60-fsec pulse generation from a self-mode-locked Ti:sapphire laser," Opt. Lett. vol. 16, no. 1, 1991.
  4. F.X. Kartner et al., "Soliton mode-locking with saturable absorbers," IEEE. J. Quant. Electron. vol. 2, no. 3, 1996, pp. 540-556. https://doi.org/10.1109/2944.571754
  5. P.F. Moulton, "Spectroscopic and laser characteristics of Ti:Al2O3," J. Opt. Soc. Am. B, vol. 3, no. 1, 1986, pp. 125-133. https://doi.org/10.1364/JOSAB.3.000125
  6. A.E. Siegman, "Lasers," in University Science Books, Sausalito, California, USA, 1986, p. 1049.
  7. D.H. Song, "Study on high-energy femtosecond laser and amplification," Ph.D. dissertation, GIST, 2012.
  8. H.A. Haus et al., "Structures for additive pulse mode locking," J. Opt. Soc. Am. B, vol. 8, no. 10, 1991, pp. 2068-2076. https://doi.org/10.1364/JOSAB.8.002068
  9. R. Ell et al., "Generation of 5-fs pulses and octave-spanning spectra directly from a Ti:sapphire laser," Opt. Lett. vol. 26, no. 6, 2001, pp. 373-375. https://doi.org/10.1364/OL.26.000373
  10. S.H. Cho et al., "Low-repetition-rate high-peak-power Kerrlens mode-locked Ti:Al2O3 laser with a multiple-pass cavity," Opt. Lett. vol. 24, no. 6, 1999, pp. 417-419. https://doi.org/10.1364/OL.24.000417
  11. S.H. Cho et al., "Generation of 90-nJ pulses with a 4-MHz repetition-rate Kerr-lens mode-locked Ti:Al2O3 laser operating with net positive and negative intracavity dispersion," Opt. Lett. vol. 26, no. 8, 2001, pp. 560-562. https://doi.org/10.1364/OL.26.000560
  12. A.M. Kowalevicz et al., "Generation of 150-nJ pulses from a multiple-pass cavity Kerr-lens mode-locked Ti:Al2O3 oscillator," Opt. Lett. vol. 28, no. 17, 2003, pp. 1597-1599. https://doi.org/10.1364/OL.28.001597
  13. P. Dombi et al., "Investigation of a 200-nJ chirped-pulse Ti:sapphire oscillator for white light generation," Laser Phys. Lett. vol. 4, no. 7, 2007, pp. 538-542. https://doi.org/10.1002/lapl.200710022
  14. D.H. Song et al., "A compact Kerr-lend mode-locked Ti:sapphire oscillator with 330 nJ soliton-like pulses," Laser Phys. Lett. vol. 10, no. 6, 2013.
  15. M. Ramaswamy et al., "Cavity-dumped femtosecond Kerr-lens mode-locked Ti:Al2O3 laser," Opt. Lett. vol. 18, no. 21, 1993, pp. 1822-1824. https://doi.org/10.1364/OL.18.001822
  16. X. Zhou et al., "Positive-dispersion cavity-dumped Ti:sapphire laser oscillator and its application to white light generation," Opt. Express, vol. 14, no. 21, 2006, pp. 9750-9757. https://doi.org/10.1364/OE.14.009750
  17. M. Siegel et al., "Microjoule pulse energy from a chirped-pulse Ti:sapphire oscillator with cavity dumping," Opt. Lett. vol. 34, no. 6, 2009, pp. 740-742. https://doi.org/10.1364/OL.34.000740
  18. W. Denk et al., "Two-photon scanning fluorescence microscopy," Sci. vol. 248, no. 4951, 1990, pp. 73-76. https://doi.org/10.1126/science.2321027
  19. M. Oheim et al., "Principles of two-photon excitation fluorescence microscopy and other nonlinear imaging approaches," Adv. Drug Deliv. Rev. vol. 58, no. 7, 2006.
  20. BCC Research, "Lasers: Global markets to 2024," 2019.