Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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β-caryophyllene improves sexual performance via modulation of crucial enzymes relevant to erectile dysfunction in rats

  • Adefegha, Stephen A. (Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology) ;
  • Oboh, Ganiyu (Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology) ;
  • Olopade, Elijah O. (Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology)
  • Received : 2020.04.28
  • Accepted : 2020.07.27
  • Published : 2021.04.15
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Abstract

This study sought to investigate the effect of β-caryophyllene (BCP) on sexual performance, crucial enzymes linked to erectile function as well as lipid peroxidation in the penile tissue of paroxetine (PD)-induced rats. Animals were randomly divided into ten groups of five animals each: normal control (NC), BCP (10 mg/kg), BCP (20 mg/kg), sildenafil citrate (SD) (20 mg/kg), BCP+SD (20 mg/kg), PD (20 mg/kg), PD+BCP (10 mg/kg), PD+BCP (20 mg/kg), PD+SD (20 mg/kg) and PD+BCP (20 mg/kg)+SD (20 mg/kg). Oral administration of 20 mg/kg body weight of PD for the first 7 days was done while treatment with BCP and SD were performed between 8 and 14 days prior to euthanasia. The sexual performance study revealed that PD caused erectile dysfuction. Elevated activities of phosphodiesterase-5' (PDE-5'), arginase, adenosine deaminase (ADA), acetylcholinesterase (AChE) and angiotensin-I converting enzyme (ACE) as well as lipid peroxidation level were observed in PD-induced rats when compared to the NC group. However, treatment with sildenafil and/ or β-Caryophyllene significantly reduced the activities of AChE, PDE-5', arginase, ADA, and ACE in penile tissues of PD-induced rats. In addition, co-administration of β-caryophyllene and sildenafil citrate showed better modulatory effects. Thus, β-caryophyllene could represent a potential nutraceutical in the management of erectile dysfunction.

Keywords

References

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