Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
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Effects of ibuprofen-loaded TiO2 nanotube dental implants in alloxan-induced diabetic rabbits

  • Kim, Young-Gyo (Department of Periodontology, Gangneung-Wonju National University College of Dentistry) ;
  • Kim, Wan-Tae (Department of Advanced Materials Engineering, Gangneung-Wonju National University) ;
  • Jung, Bo Hyun (Department of Anatomy, Gangneung-Wonju National University College of Dentistry) ;
  • Yoo, Ki-Yeon (Department of Anatomy, Gangneung-Wonju National University College of Dentistry) ;
  • Um, Heung-Sik (Department of Periodontology, Gangneung-Wonju National University College of Dentistry) ;
  • Chang, Beom-Seok (Department of Periodontology, Gangneung-Wonju National University College of Dentistry) ;
  • Lee, Jae-Kwan (Department of Periodontology, Gangneung-Wonju National University College of Dentistry) ;
  • Choi, Won-Youl (Department of Advanced Materials Engineering, Gangneung-Wonju National University)
  • Received : 2020.12.01
  • Accepted : 2021.03.22
  • Published : 2021.10.30
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Abstract

Purpose: Some systemic conditions, especially diabetes mellitus (DM), adversely affect dental implant success. This study aimed to investigate the effects of ibuprofen-loaded TiO2 nanotube (ILTN) dental implants in alloxan-induced diabetic rabbits. Methods: Twenty-six New Zealand white rabbits were treated with alloxan monohydrate to induce DM. At 2 weeks following DM induction, 3 types of implants (sandblasted, large-grit, and acid-etched [SLA], ILTN, and machined) were placed into the proximal tibia in the 10 rabbits that survived following DM induction. Each type of implant was fitted randomly in 1 of the holes (round-robin method). The animals were administered alizarin (at 3 weeks) and calcein (at 6 weeks) as fluorescent bone markers, and were sacrificed at 8 weeks for radiographic and histomorphometric analyses. Results: TiO2 nanotube arrays of ~70 nm in diameter and ~17 ㎛ in thickness were obtained, and ibuprofen was loaded into the TiO2 nanotube arrays. A total of 26 rabbits were treated with alloxan monohydrate and only 10 rabbits survived. The 10 surviving rabbits showed a blood glucose level of 300 mg/dL or higher, and the implants were placed in these diabetic rabbits. The implant stability quotient (ISQ) and bone-to-implant contact (BIC) values were significantly higher in the ILTN group (ISQ: 61.8, BIC: 41.3%) and SLA group (ISQ: 62.6, BIC: 46.3%) than in the machined group (ISQ: 53.4, BIC: 20.2%), but the difference in the BIC percentage between the SLA and ILTN groups was not statistically significant (P=0.628). However, the bone area percentage was significantly higher in the ILTN group (78.0%) than in the SLA group (52.1%; P=0.000). Conclusions: The: ILTN dental implants showed better stability (ISQ) and BIC than the machined implants; however, these values were similar to the commercially used SLA implants in the 2-week diabetic rabbit model.

Keywords

Acknowledgement

This research was financially supported by National Research Foundation of Korea (Grant No. 2015H1C1A1035848 and 2019R1I1A3A01057765).

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