한방재활의학과학회지 (Journal of Korean Medicine Rehabilitation)

  • 제31권4호
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  • Pages.167-191
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  • 2021
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  • 1229-1854(pISSN)
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  • 2288-4114(eISSN)
한방재활의학과학회 (The society of Korean Medicine Rehabilitation)
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경증의 퇴행성 슬관절염에 대한 초피나무잎 추출물의 유효성 및 안전성 평가: 무작위 배정, 이중맹검, 위약대조 임상연구

Evaluation of the Effectiveness and Safety of Zanthoxylum piperitum Leaf Extract against Mild Degenerative Osteoarthritis of Knee: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

  • 정지홍 (세명대학교 한의과대학 한방재활의학교실) ;
  • 이수환 (세명대학교 한의과대학 한방재활의학교실) ;
  • 윤홍렬 (세명대학교 한의과대학 한방재활의학교실) ;
  • 김순중 (세명대학교 한의과대학 한방재활의학교실)
  • Jeong, Ji-Hong (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University) ;
  • Lee, Soo-Hwan (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University) ;
  • Yoon, Hong-Ryoul (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University) ;
  • Kim, Soon-Joong (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Semyung University)
  • 투고 : 2021.09.16
  • 심사 : 2021.10.07
  • 발행 : 2021.10.31
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초록

Objectives Degenerative osteoarthritis of knee is a disease with an increasing number of patients worldwide and its general treatments have some side effects. Methods 102 subjects were classified into test group 1, test group 2, and control group, and clinical trial products were taken for 12 weeks. The effectiveness was evaluated with changes in visual analogue scale, Korean-Western Ontario and McMaster Universities Osteoarthritis Index, inducible nitric oxide synthase, and cyclooxygenase-2. Results Both test group 1 and test group 2 were effective in reducing the pain of degenerative osteoarthritis of knee, and only test group 2 was effective in improving the ability to perform daily activities. No clinically significant changes were observed for any safety parameter. Conclusions In conclusion, the data of this study indicate that Zanthoxylum piperitum leaf extract has effectiveness and safety against mild degenerative osteoarthritis of knee.

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참고문헌

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