Acknowledgement
This work was supported by grants (NRF-2019R1A5A2027521 and 2021R1A2C300572711) of the National Research Foundation of Korea (NRF) funded by the Korea government (MSIT), the Korea Healthcare Technology R&D Project of the Korea Health Industry Development Institute (HR14C0008), and Chonnam National University Hospital Biomedical Research Institute (BCRI18012).
References
- Loeser RF, Goldring SR, Scanzello CR and Goldring MB (2012) Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum 64, 1697-1707 https://doi.org/10.1002/art.34453
- Yang S, Kim J, Ryu JH et al (2010) Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 16, 687-693 https://doi.org/10.1038/nm.2153
- Goldring MB and Goldring SR (2007) Osteoarthritis. J Cell Physiol 213, 626-634 https://doi.org/10.1002/jcp.21258
- Hashimoto M, Nakasa T, Hikata T and Asahara H (2008) Molecular network of cartilage homeostasis and osteoarthritis. Med Res Rev 28, 464-481 https://doi.org/10.1002/med.20113
- Roman-Blas JA and Jimenez SA (2006) NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthr Cartil 14, 839-848 https://doi.org/10.1016/j.joca.2006.04.008
- Kim JH, Jeon J, Shin M et al (2014) Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. Cell 156, 730-43 https://doi.org/10.1016/j.cell.2014.01.007
- Mengshol JA, Vincenti MP, Coon CI, Barchowsky A and Brinckerhoff CE (2000) Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3. Arthritis Rheum 43, 801-811 https://doi.org/10.1002/1529-0131(200004)43:4<801::AID-ANR10>3.0.CO;2-4
- Zeng Li, Xiaofeng Rong, Rong-Heng Li and X Wu (2017) Icariin inhibits MMP 1, MMP 3 and MMP 13 expression through MAPK pathways in IL 1β stimulated SW1353 chondrosarcoma cells. Mol Med Rep 15, 2853-2858 https://doi.org/10.3892/mmr.2017.6312
- Chang SH, Mori D, Kobayashi H et al (2019) Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. Nat Commun 10, 1442 https://doi.org/10.1038/s41467-019-09491-5
- Roman-Blas JA and Jimenez SA (2006) NF-kappaB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthr Cartil 14, 839-848 https://doi.org/10.1016/j.joca.2006.04.008
- Collins FW (1989) Oat phenolics: avenanthramides, novel substituted N-cinnamoylanthranilate alkaloids from oat groats and hulls. J Agric Food Chem 37, 60-66 https://doi.org/10.1021/jf00085a015
- Othman RA, Moghadasian MH and Jones PJ (2011) Cholesterol-lowering effects of oat β-glucan. Nutr Rev 69, 299- 309 https://doi.org/10.1111/j.1753-4887.2011.00401.x
- Peterson, David & Hahn, Martha & Emmons and Cheryld (2002) Oat avenanthramides exhibit antioxidant activities in vitro. Food Chem 79, 473-478 https://doi.org/10.1016/S0308-8146(02)00219-4
- Emmons CL, Peterson DM and Paul GL (1999) Antioxidant capacity of oat (Avena sativa L.) extracts. 2. In vitro antioxidant activity and contents of phenolic and tocol antioxidants. J Agric Food Chem 47, 4894-4898 https://doi.org/10.1021/jf990530i
- Guo W, Nie L, Wu D et al (2010) Avenanthramides inhibit proliferation of human colon cancer cell lines in vitro. Nutr Cancer 62, 1007-1016 https://doi.org/10.1080/01635581.2010.492090
- Guo W, Wise ML, Collins FW and Meydani M (2008) Avenanthramides, polyphenols from oats, inhibit IL-1beta-induced NF-kappaB activation in endothelial cells. Free Radic Biol Med 44, 415-429 https://doi.org/10.1016/j.freeradbiomed.2007.10.036
- Kang C, Shin WS, Yeo D, Lim W, Zhang T and Ji LL (2018) Anti-inflammatory effect of avenanthramides via NF-κB pathways in C2C12 skeletal muscle cells. Free Radic Biol Med 117, 30-36 https://doi.org/10.1016/j.freeradbiomed.2018.01.020
- Lim W and Kang C (2020) Avenanthramide C suppresses hypoxia-induced cyclooxygenase-2 expression through sirtuin1 activation in non-small-cell lung cancer cells. Anim Cells Syst 24, 79-83 https://doi.org/10.1080/19768354.2020.1748108
- Nakasa T, Adachi N, Kato T, Ochi M (2014) Correlation between subchondral bone plate thickness and cartilage degeneration in osteoarthritis of the ankle. Foot Ankle Int 35, 1341-1349 https://doi.org/10.1177/1071100714548061
- Saklatvala J (2007) Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis. Curr Drug Targets 8, 305-313 https://doi.org/10.2174/138945007779940115
- Liu T, Zhang L, Joo D, Sun SC (2017) NF-κB signaling in inflammation. Signal Transduct Target Ther 2,17023 https://doi.org/10.1038/sigtrans.2017.23
- Guilak F (2011) Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol 25, 815-823 https://doi.org/10.1016/j.berh.2011.11.013
- Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP and Fahmi H (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7, 33-42 https://doi.org/10.1038/nrrheum.2010.196
- Yun S, Dardik A, Haga M et al (2002) Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium. J Biol Chem 277, 34808-34814 https://doi.org/10.1074/jbc.M205417200
- Pan MR and Hung WC (2002) Nonsteroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 via suppression of the ERK/Sp1-mediated transcription. J Biol Chem 277, 32775-32780 https://doi.org/10.1074/jbc.M202334200
- Pulai JI, Chen H, Im HJ et al (2005) NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol 174, 5781-5788 https://doi.org/10.4049/jimmunol.174.9.5781
- Loeser RF, Erickson EA and Long DL (2008) Mitogen-activated protein kinases as therapeutic targets in osteoarthritis. Curr Opin Rheumatol 20, 581-586 https://doi.org/10.1097/BOR.0b013e3283090463