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An update on the cause and treatment of sleep disturbance in children and adolescents with autism spectrum disorder

  • Seo, Wan Seok (Department of Psychiatry, Yeungnam University College of Medicine)
  • 투고 : 2021.08.06
  • 심사 : 2021.08.25
  • 발행 : 2021.10.31

초록

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by abnormalities in social communication/interaction and restrictive, repetitive patterns of behavior. ASD is a relatively common psychiatric disorder, with a prevalence of approximately 1.7% in children. Although many children and adolescents with ASD visit the hospital for medical help for emotional and behavioral problems such as mood instability and self-harming behavior, there are also many visits for sleep disturbances such as insomnia and sleep resistance. Sleep disturbances are likely to increase fatigue and daytime sleepiness, impaired concentration, negatively impact on daytime functioning, and pose challenges in controlling anger and aggressive behavior. Sleep disturbance in children and adolescents with ASD negatively affects the quality of life, nothing to say the quality of life of their families and school members. In this review, sleep disturbances that are common in children and adolescents with ASD and adolescents are presented. The developmental and behavioral impacts of sleep disturbances in ASD were also considered. Finally, non-pharmacological and pharmacological treatments for sleep disturbances in children and adolescents with ASD and adolescents are reviewed.

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참고문헌

  1. Hyman SL, Levy SE, Myersh SM; Council on Children with Disabilities, Section on Developmental and Behavioral Pediatrics. Identification, evaluation, and management of children with autism spectrum disorder. Pediatrics 2020;145:e20193447. https://doi.org/10.1542/peds.2019-3447
  2. Werling DM, Parikshak NN, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nat Commun 2016;7:10717. https://doi.org/10.1038/ncomms10717
  3. Eapen V, Crncec R, Walter A. Clinical outcomes of an early intervention program for preschool children with Autism Spectrum Disorder in a community group setting. BMC Pediatr 2013;13:3. https://doi.org/10.1186/1471-2431-13-3
  4. Hirata I, Mohri I, Kato-Nishimura K, Tachibana M, Kuwada A, Kagitani-Shimono K, et al. Sleep problems are more frequent and associated with problematic behaviors in preschoolers with autism spectrum disorder. Res Dev Disabil 2016;49-50:86-99. https://doi.org/10.1016/j.ridd.2015.11.002
  5. Buckley AW, Rodriguez AJ, Jennison K, Buckley J, Thurm A, Sato S, et al. Rapid eye movement sleep percentage in children with autism compared with children with developmental delay and typical development. Arch Pediatr Adolesc Med 2010;164:1032-7. https://doi.org/10.1001/archpediatrics.2010.202
  6. Hodge D, Carollo TM, Lewin M, Hoffman CD, Sweeney DP. Sleep patterns in children with and without autism spectrum disorders: developmental comparisons. Res Dev Disabil 2014;35:1631-8. https://doi.org/10.1016/j.ridd.2014.03.037
  7. Malow BA, Crowe C, Henderson L, McGrew SG, Wang L, Song Y, et al. A sleep habits questionnaire for children with autism spectrum disorders. J Child Neurol 2009;24:19-24. https://doi.org/10.1177/0883073808321044
  8. Richdale AL, Schreck KA. Sleep problems in autism spectrum disorders: prevalence, nature, & possible biopsychosocial aetiologies. Sleep Med Rev 2009;13:403-11. https://doi.org/10.1016/j.smrv.2009.02.003
  9. Mazurek MO, Sohl K. Sleep and behavioral problems in children with autism spectrum disorder. J Autism Dev Disord 2016;46:1906-15. https://doi.org/10.1007/s10803-016-2723-7
  10. Cohen S, Conduit R, Lockley SW, Rajaratnam SM, Cornish KM. The relationship between sleep and behavior in autism spectrum disorder (ASD): a review. J Neurodev Disord 2014;6:44. https://doi.org/10.1186/1866-1955-6-44
  11. Hollway JA, Aman MG. Sleep correlates of pervasive developmental disorders: a review of the literature. Res Dev Disabil 2011;32:1399-421. https://doi.org/10.1016/j.ridd.2011.04.001
  12. Elrod MG, Hood BS. Sleep differences among children with autism spectrum disorders and typically developing peers: a meta-analysis. J Dev Behav Pediatr 2015;36:166-77. https://doi.org/10.1097/dbp.0000000000000140
  13. Kotagal S, Broomall E. Sleep in children with autism spectrum disorder. Pediatr Neurol 2012;47:242-51. https://doi.org/10.1016/j.pediatrneurol.2012.05.007
  14. Adkins KW, Molloy C, Weiss SK, Reynolds A, Goldman SE, Burnette C, et al. Effects of a standardized pamphlet on insomnia in children with autism spectrum disorders. Pediatrics 2012;130(Suppl 2):S139-44. https://doi.org/10.1542/peds.2012-0900K
  15. Sikora DM, Johnson K, Clemons T, Katz T. The relationship between sleep problems and daytime behavior in children of different ages with autism spectrum disorders. Pediatrics 2012;130(Suppl 2):S83-90. https://doi.org/10.1542/peds.2012-0900F
  16. Adams HL, Matson JL, Jang J. The relationship between sleep problems and challenging behavior among children and adolescents with autism spectrum disorder. Res Autism Spectr Disord 2014;8:1024-30. https://doi.org/10.1016/j.rasd.2014.05.008
  17. Lindor E, Sivaratnam C, May T, Stefanac N, Howells K, Rinehart N. Problem behavior in autism spectrum disorder: considering core symptom severity and accompanying sleep disturbance. Front Psychiatry 2019;10:487. https://doi.org/10.3389/fpsyt.2019.00487
  18. Malow BA, Marzec ML, McGrew SG, Wang L, Henderson LM, Stone WL. Characterizing sleep in children with autism spectrum disorders: a multidimensional approach. Sleep 2006;29:1563-71. https://doi.org/10.1093/sleep/29.12.1563
  19. Goldman SE, Surdyka K, Cuevas R, Adkins K, Wang L, Malow BA. Defining the sleep phenotype in children with autism. Dev Neuropsychol 2009;34:560-73. https://doi.org/10.1080/87565640903133509
  20. Cohen S, Fulcher BD, Rajaratnam SM, Conduit R, Sullivan JP, St Hilaire MA, et al. Sleep patterns predictive of daytime challenging behavior in individuals with low-functioning autism. Autism Res 2018;11:391-403. https://doi.org/10.1002/aur.1899
  21. Souders MC, Mason TB, Valladares O, Bucan M, Levy SE, Mandell DS, et al. Sleep behaviors and sleep quality in children with autism spectrum disorders. Sleep 2009;32:1566-78. https://doi.org/10.1093/sleep/32.12.1566
  22. Bourgeron T. The possible interplay of synaptic and clock genes in autism spectrum disorders. Cold Spring Harb Symp Quant Biol 2007;72:645-54. https://doi.org/10.1101/sqb.2007.72.020
  23. Tordjman S, Najjar I, Bellissant E, Anderson GM, Barburoth M, Cohen D, et al. Advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives. Int J Mol Sci 2013;14:20508-42. https://doi.org/10.3390/ijms141020508
  24. Foley LS, Maddison R, Jiang Y, Marsh S, Olds T, Ridley K. Presleep activities and time of sleep onset in children. Pediatrics 2013;131:276-82. https://doi.org/10.1542/peds.2012-1651
  25. Engelhardt CR, Mazurek MO, Sohl K. Media use and sleep among boys with autism spectrum disorder, ADHD, or typical development. Pediatrics 2013;132:1081-9. https://doi.org/10.1542/peds.2013-2066
  26. Waddington H, McLay L, Woods L, Whitehouse AJ. Child and family characteristics associated with sleep disturbance in children with autism spectrum disorder. J Autism Dev Disord 2020;50:4121-32. https://doi.org/10.1007/s10803-020-04475-7
  27. Martin CA, Papadopoulos N, Chellew T, Rinehart NJ, Sciberras E. Associations between parenting stress, parent mental health and child sleep problems for children with ADHD and ASD: systematic review. Res Dev Disabil 2019;93:103463. https://doi.org/10.1016/j.ridd.2019.103463
  28. Bonnet MH, Arand DL. Hyperarousal and insomnia: state of the science. Sleep Med Rev 2010;14:9-15. https://doi.org/10.1016/j.smrv.2009.05.002
  29. Healey ES, Kales A, Monroe LJ, Bixler EO, Chamberlin K, Soldatos CR. Onset of insomnia: role of life-stress events. Psychosom Med 1981;43:439-51. https://doi.org/10.1097/00006842-198110000-00007
  30. Morin CM, Rodrigue S, Ivers H. Role of stress, arousal, and coping skills in primary insomnia. Psychosom Med 2003;65:259-67. https://doi.org/10.1097/01.PSY.0000030391.09558.A3
  31. Valentino RJ, Van Bockstaele E. Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur J Pharmacol 2008;583:194-203. https://doi.org/10.1016/j.ejphar.2007.11.062
  32. Reynolds S, Lane SJ, Thacker L. Sensory processing, physiological stress, and sleep behaviors in children with and without autism spectrum disorders. OTJR (Thorofare N J) 2012;32:246-57. https://doi.org/10.3928/15394492-20110513-02
  33. Mazurek MO, Petroski GF. Sleep problems in children with autism spectrum disorder: examining the contributions of sensory over-responsivity and anxiety. Sleep Med 2015;16:270-9. https://doi.org/10.1016/j.sleep.2014.11.006
  34. Wimpory D, Nicholas B, Nash S. Social timing, clock genes and autism: a new hypothesis. J Intellect Disabil Res 2002;46(Pt 4):352-8. https://doi.org/10.1046/j.1365-2788.2002.00423.x
  35. Veatch OJ, Keenan BT, Gehrman PR, Malow BA, Pack AI. Pleiotropic genetic effects influencing sleep and neurological disorders. Lancet Neurol 2017;16:158-70. https://doi.org/10.1016/S1474-4422(16)30339-8
  36. Veatch OJ, Veenstra-Vanderweele J, Potter M, Pericak-Vance MA, Haines JL. Genetically meaningful phenotypic subgroups in autism spectrum disorders. Genes Brain Behav 2014;13:276-85. https://doi.org/10.1111/gbb.12117
  37. Yang Z, Matsumoto A, Nakayama K, Jimbo EF, Kojima K, Nagata K, et al. Circadian-relevant genes are highly polymorphic in autism spectrum disorder patients. Brain Dev 2016;38:91-9. https://doi.org/10.1016/j.braindev.2015.04.006
  38. Carmassi C, Palagini L, Caruso D, Masci I, Nobili L, Vita A, et al. Systematic review of sleep disturbances and circadian sleep desynchronization in autism spectrum disorder: toward an integrative model of a self-reinforcing loop. Front Psychiatry 2019;10:366. https://doi.org/10.3389/fpsyt.2019.00366
  39. Veatch OJ, Pendergast JS, Allen MJ, Leu RM, Johnson CH, Elsea SH, et al. Genetic variation in melatonin pathway enzymes in children with autism spectrum disorder and comorbid sleep onset delay. J Autism Dev Disord 2015;45:100-10. https://doi.org/10.1007/s10803-014-2197-4
  40. Melke J, Goubran Botros H, Chaste P, Betancur C, Nygren G, Anckarsater H, et al. Abnormal melatonin synthesis in autism spectrum disorders. Mol Psychiatry 2008;13:90-8. https://doi.org/10.1038/sj.mp.4002016
  41. Mulder EJ, Anderson GM, Kemperman RF, Oosterloo-Duinkerken A, Minderaa RB, Kema IP. Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals. Neuropsychobiology 2010;61:27-32. https://doi.org/10.1159/000258640
  42. Kerns CM, Kendall PC, Berry L, Souders MC, Franklin ME, Schultz RT, et al. Traditional and atypical presentations of anxiety in youth with autism spectrum disorder. J Autism Dev Disord 2014;44:2851-61. https://doi.org/10.1007/s10803-014-2141-7
  43. Yerys BE, Wallace GL, Sokoloff JL, Shook DA, James JD, Kenworthy L. Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders. Autism Res 2009;2:322-33.
  44. Panju S, Brian J, Dupuis A, Anagnostou E, Kushki A. Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology. Mol Autism 2015;6:64. https://doi.org/10.1186/s13229-015-0057-5
  45. Ibanez V, Silva J, Cauli O. A survey on sleep questionnaires and diaries. Sleep Med 2018;42:90-6. https://doi.org/10.1016/j.sleep.2017.08.026
  46. Owens JA, Spirito A, McGuinn M. The Children's Sleep Habits Questionnaire (CSHQ): psychometric properties of a survey instrument for school-aged children. Sleep 2000;23:1043-51.
  47. Aman MG, Singh NN, Stewart AW, Field CJ. The aberrant behavior checklist: a behavior rating scale for the assessment of treatment effects. Am J Ment Defic 1985;89:485-91.
  48. Malow BA, Byars K, Johnson K, Weiss S, Bernal P, Goldman SE, et al. A practice pathway for the identification, evaluation, and management of insomnia in children and adolescents with autism spectrum disorders. Pediatrics 2012;130(Suppl 2):S106-24. https://doi.org/10.1542/peds.2012-0900I
  49. Malow BA, Adkins KW, Reynolds A, Weiss SK, Loh A, Fawkes D, et al. Parent-based sleep education for children with autism spectrum disorders. J Autism Dev Disord 2014;44:216-28. https://doi.org/10.1007/s10803-013-1866-z
  50. Andersen IM, Kaczmarska J, McGrew SG, Malow BA. Melatonin for insomnia in children with autism spectrum disorders. J Child Neurol 2008;23:482-5. https://doi.org/10.1177/0883073807309783
  51. Gringras P, Green D, Wright B, Rush C, Sparrowhawk M, Pratt K, et al. Weighted blankets and sleep in autistic children: a randomized controlled trial. Pediatrics 2014;134:298-306. https://doi.org/10.1542/peds.2013-4285
  52. Frazier TW, Krishna J, Klingemier E, Beukemann M, Nawabit R, Ibrahim S. A randomized, crossover trial of a novel sound-to-sleep mattress technology in children with autism and sleep difficulties. J Clin Sleep Med 2017;13:95-104. https://doi.org/10.5664/jcsm.6398
  53. Malow BA, Katz T, Reynolds AM, Shui A, Carno M, Connolly HV, et al. Sleep difficulties and medications in children with autism spectrum disorders: a registry study. Pediatrics 2016;137(Suppl 2):S98-104. https://doi.org/10.1542/peds.2015-2851H
  54. Gringras P, Nir T, Breddy J, Frydman-Marom A, Findling RL. Efficacy and safety of pediatric prolonged-release melatonin for insomnia in children with autism spectrum disorder. J Am Acad Child Adolesc Psychiatry 2017;56:948-57. https://doi.org/10.1016/j.jaac.2017.09.414
  55. Cortesi F, Giannotti F, Sebastiani T, Panunzi S, Valente D. Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. J Sleep Res 2012;21:700-9. https://doi.org/10.1111/j.1365-2869.2012.01021.x
  56. Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol 2011;53:783-92. https://doi.org/10.1111/j.1469-8749.2011.03980.x
  57. Fiks AG, Mayne SL, Song L, Steffes J, Liu W, McCarn B, et al. Changing patterns of alpha agonist medication use in children and adolescents 2009-2011. J Child Adolesc Psychopharmacol 2015;25:362-7. https://doi.org/10.1089/cap.2014.0122
  58. Golubchik P, Sever J, Weizman A. Low-dose quetiapine for adolescents with autistic spectrum disorder and aggressive behavior: open-label trial. Clin Neuropharmacol 2011;34:216-9. https://doi.org/10.1097/WNF.0b013e31823349ac

피인용 문헌

  1. Understanding sleep and sleep disturbances in autism spectrum disorder, and management of insomnia: an update vol.38, pp.4, 2021, https://doi.org/10.12701/yujm.2021.01459