DOI QR코드

DOI QR Code

Revised Korean Cough Guidelines, 2020: Recommendations and Summary Statements

  • Joo, Hyonsoo (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Moon, Ji-Yong (Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine) ;
  • An, Tai Joon (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Choi, Hayoung (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Park, So Young (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University) ;
  • Yoo, Hongseok (Division of Pulmonary and Critical Care Medicine, Department of Medicine, Lung and Esophageal Cancer Center, Sungkyunkwan University School of Medicine, Samsung Medical Center) ;
  • Kim, Chi Young (Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Ansan Hospital) ;
  • Jeong, Ina (Department of Internal Medicine, National Medical Center) ;
  • Kim, Joo-Hee (Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Koo, Hyeon-Kyoung (Divison of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Inje University Ilsan Paik Hospital, Inje University College of Medicine) ;
  • Rhee, Chin Kook (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Lee, Sei Won (Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Sung Kyoung (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Min, Kyung Hoon (Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine) ;
  • Kim, Yee Hyung (Department of Pulmonary, Allergy, and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine) ;
  • Jang, Seung Hun (Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Deog Kyeom (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine) ;
  • Shin, Jong Wook (Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, ChungAng University College of Medicine) ;
  • Yoon, Hyoung Kyu (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Dong-Gyu (Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Hui Jung (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine) ;
  • Kim, Jin Woo (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • Received : 2021.03.10
  • Accepted : 2021.05.03
  • Published : 2021.10.31

Abstract

Cough is the most common respiratory symptom that can have various causes. It is a major clinical problem that can reduce a patient's quality of life. Thus, clinical guidelines for the treatment of cough were established in 2014 by the cough guideline committee under the Korean Academy of Tuberculosis and Respiratory Diseases. From October 2018 to July 2020, cough guidelines were revised by members of the committee based on the first guidelines. The purpose of these guidelines is to help clinicians efficiently diagnose and treat patients with cough. This article highlights the recommendations and summary of the revised Korean cough guidelines. It includes a revised algorithm for the evaluation of acute, subacute, and chronic cough. For a chronic cough, upper airway cough syndrome (UACS), cough variant asthma (CVA), and gastroesophageal reflux disease (GERD) should be considered in differential diagnoses. If UACS is suspected, first-generation antihistamines and nasal decongestants can be used empirically. In cases with CVA, inhaled corticosteroids are recommended to improve cough. In patients with suspected chronic cough due to symptomatic GERD, proton pump inhibitors are recommended. Chronic bronchitis, bronchiectasis, bronchiolitis, lung cancer, aspiration, intake of angiotensin-converting enzyme inhibitor, intake of dipeptidyl peptidase-4 inhibitor, habitual cough, psychogenic cough, interstitial lung disease, environmental and occupational factors, tuberculosis, obstructive sleep apnea, peritoneal dialysis, and unexplained cough can also be considered as causes of a chronic cough. Chronic cough due to laryngeal dysfunction syndrome has been newly added to the guidelines.

Keywords

References

  1. Irwin RS, French CT, Lewis SZ, Diekemper RL, Gold PM; CHEST Expert Cough Panel. Overview of the management of cough: CHEST Guideline and Expert Panel Report. Chest 2014;146:885-9. https://doi.org/10.1378/chest.14-1485
  2. Irwin RS. Complications of cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129(1 Suppl):54S-8S. https://doi.org/10.1378/chest.129.1_suppl.54S
  3. Birring SS, Prudon B, Carr AJ, Singh SJ, Morgan MD, Pavord ID. Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Thorax 2003;58:339-43. https://doi.org/10.1136/thorax.58.4.339
  4. Pratter MR, Brightling CE, Boulet LP, Irwin RS. An empiric integrative approach to the management of cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129(1 Suppl):222S-31S. https://doi.org/10.1378/chest.129.1_suppl.222S
  5. Irwin RS, French CL, Chang AB, Altman KW; CHEST Expert Cough Panel. Classification of cough as a symptom in adults and management algorithms: CHEST Guideline and Expert Panel report. Chest 2018;153:196-209. https://doi.org/10.1016/j.chest.2017.10.016
  6. Koo HK, Jeong I, Kim JH, Kim SK, Shin JW, Park SY, et al. Development and validation of the COugh Assessment Test (COAT). Respirology 2019;24:551-7. https://doi.org/10.1111/resp.13462
  7. Lee KK, Matos S, Evans DH, White P, Pavord ID, Birring SS. A longitudinal assessment of acute cough. Am J Respir Crit Care Med 2013;187:991-7. https://doi.org/10.1164/rccm.201209-1686OC
  8. Hsu JY, Stone RA, Logan-Sinclair RB, Worsdell M, Busst CM, Chung KF. Coughing frequency in patients with persistent cough: assessment using a 24 hour ambulatory recorder. Eur Respir J 1994;7:1246-53. https://doi.org/10.1183/09031936.94.07071246
  9. Becker LA, Hom J, Villasis-Keever M, van der Wouden JC. Beta2-agonists for acute cough or a clinical diagnosis of acute bronchitis. Cochrane Database Syst Rev 2015;2015:CD001726.
  10. Armstrong GL, Pinner RW. Outpatient visits for infectious diseases in the United States, 1980 through 1996. Arch Intern Med 1999;159:2531-6. https://doi.org/10.1001/archinte.159.21.2531
  11. Braman SS. Postinfectious cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129(1 Suppl):138S46S.
  12. Asthma Workgroup, Chinese Society, Respiratory, Diseases (CSRD), Chinese Medical, Association. The Chinese national guidelines on diagnosis and management of cough (December 2010). Chin Med J (Engl) 2011;124:3207-19.
  13. Committee for the Japanese Respiratory Society Guidelines for Management of Cough; Kohno S, Ishida T, Uchida Y, Kishimoto H, Sasaki H, et al. The Japanese Respiratory Society guidelines for management of cough. Respirology 2006;11 Suppl 4:S135-86. https://doi.org/10.1111/j.1440-1843.2006.00920_1.x
  14. McGarvey LP. Cough 6: Which investigations are most useful in the diagnosis of chronic cough? Thorax 2004;59:342-6. https://doi.org/10.1136/thx.2004.021832
  15. Morice AH, McGarvey L, Pavord I; British Thoracic Society Cough Guideline Group. Recommendations for the management of cough in adults. Thorax 2006;61 Suppl 1:i1-24. https://doi.org/10.1136/thx.2006.065144
  16. Pratter MR, Bartter T, Akers S, DuBois J. An algorithmic approach to chronic cough. Ann Intern Med 1993;119:977-83. https://doi.org/10.7326/0003-4819-119-10-199311150-00003
  17. Irwin RS, Curley FJ, French CL. Chronic cough. The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy. Am Rev Respir Dis 1990;141:640-7. https://doi.org/10.1164/ajrccm/141.3.640
  18. Morice AH. Post-nasal drip syndrome: a symptom to be sniffed at? Pulm Pharmacol Ther 2004;17:343-5. https://doi.org/10.1016/j.pupt.2004.09.005
  19. Pratter MR, Bartter T, Lotano R. The role of sinus imaging in the treatment of chronic cough in adults. Chest 1999;116:1287-91. https://doi.org/10.1378/chest.116.5.1287
  20. Cote A, Russell RJ, Boulet LP, Gibson PG, Lai K, Irwin RS, et al. Managing chronic cough due to asthma and NAEB in adults and adolescents: CHEST Guideline and Expert Panel report. Chest 2020;158:68-96. https://doi.org/10.1016/j.chest.2019.12.021
  21. Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald JM, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 2008;31:143-78. https://doi.org/10.1183/09031936.00138707
  22. Gibson PG, Dolovich J, Denburg J, Ramsdale EH, Hargreave FE. Chronic cough: eosinophilic bronchitis without asthma. Lancet 1989;1:1346-8.
  23. Brightling CE, Ward R, Goh KL, Wardlaw AJ, Pavord ID. Eosinophilic bronchitis is an important cause of chronic cough. Am J Respir Crit Care Med 1999;160:406-10. https://doi.org/10.1164/ajrccm.160.2.9810100
  24. Khan BA, Sodhi JS, Zargar SA, Javid G, Yattoo GN, Shah A, et al. Effect of bed head elevation during sleep in symptomatic patients of nocturnal gastroesophageal reflux. J Gastroenterol Hepatol 2012;27:1078-82. https://doi.org/10.1111/j.1440-1746.2011.06968.x
  25. Kahrilas PJ, Altman KW, Chang AB, Field SK, Harding SM, Lane AP, et al. Chronic cough due to gastroesophageal reflux in adults: CHEST Guideline and Expert Panel report. Chest 2016;150:1341-60. https://doi.org/10.1016/j.chest.2016.08.1458
  26. Chang AB, Lasserson TJ, Kiljander TO, Connor FL, Gaffney JT, Garske LA. Systematic review and meta-analysis of randomised controlled trials of gastro-oesophageal reflux interventions for chronic cough associated with gastro-oesophageal reflux. BMJ 2006;332:11-7. https://doi.org/10.1136/bmj.38677.559005.55
  27. Chang AB, Lasserson TJ, Gaffney J, Connor FL, Garske LA. Gastro-oesophageal reflux treatment for prolonged nonspecific cough in children and adults. Cochrane Database Syst Rev 2011;2011:CD004823.
  28. Kanner RE, Connett JE, Williams DE, Buist AS. Effects of randomized assignment to a smoking cessation intervention and changes in smoking habits on respiratory symptoms in smokers with early chronic obstructive pulmonary disease: the Lung Health Study. Am J Med 1999;106:410-6. https://doi.org/10.1016/S0002-9343(99)00056-X
  29. Wynder EL, Kaufman PL, Lesser RL. A short-term follow-up study on ex-cigarette smokers: with special emphasis on persistent cough and weight gain. Am Rev Respir Dis 1967;96:645-55.
  30. Malesker MA, Callahan-Lyon P, Madison JM, Ireland B, Irwin RS; CHEST Expert Cough Panel. Chronic cough due to stable chronic bronchitis: CHEST Expert Panel report. Chest 2020;158:705-18. https://doi.org/10.1016/j.chest.2020.02.015
  31. Cazzola M, Floriani I, Page CP. The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data. Pulm Pharmacol Ther 2010;23:135-44. https://doi.org/10.1016/j.pupt.2009.10.002
  32. Calverley P, Pauwels R, Vestbo J, Jones P, Pride N, Gulsvik A, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003;361:449-56. https://doi.org/10.1016/S0140-6736(03)12459-2
  33. McGuinness G, Naidich DP. CT of airways disease and bronchiectasis. Radiol Clin North Am 2002;40:1-19. https://doi.org/10.1016/S0033-8389(03)00105-2
  34. Serisier DJ, Martin ML, McGuckin MA, Lourie R, Chen AC, Brain B, et al. Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. JAMA 2013;309:1260-7. https://doi.org/10.1001/jama.2013.2290
  35. Altenburg J, de Graaff CS, Stienstra Y, Sloos JH, van Haren EH, Koppers RJ, et al. Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial. JAMA 2013;309:1251-9. https://doi.org/10.1001/jama.2013.1937
  36. Wong C, Jayaram L, Karalus N, Eaton T, Tong C, Hockey H, et al. Azithromycin for prevention of exacerbations in noncystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. Lancet 2012;380:660-7. https://doi.org/10.1016/S0140-6736(12)60953-2
  37. Evans DJ, Bara AI, Greenstone M. Prolonged antibiotics for purulent bronchiectasis in children and adults. Cochrane Database Syst Rev 2007;(2):CD001392.
  38. Brown KK. Chronic cough due to nonbronchiectatic suppurative airway disease (bronchiolitis): ACCP evidence-based clinical practice guidelines. Chest 2006;129(1 Suppl):132S-7S. https://doi.org/10.1378/chest.129.1_suppl.132S
  39. Shure D. Radiographically occult endobronchial obstruction in bronchogenic carcinoma. Am J Med 1991;91:19-22. https://doi.org/10.1016/0002-9343(91)90068-9
  40. Molassiotis A, Smith JA, Mazzone P, Blackhall F, Irwin RS; CHEST Expert Cough Panel. Symptomatic treatment of cough among adult patients with lung cancer: CHEST Guideline and Expert Panel report. Chest 2017;151:861-74. https://doi.org/10.1016/j.chest.2016.12.028
  41. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non-small-cell lung cancer. N Engl J Med 2010;363:733-42. https://doi.org/10.1056/NEJMoa1000678
  42. Molassiotis A, Smith JA, Bennett MI, Blackhall F, Taylor D, Zavery B, et al. Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. Cough 2010;6:9. https://doi.org/10.1186/1745-9974-6-9
  43. Robbins J, Coyle J, Rosenbek J, Roecker E, Wood J. Differentiation of normal and abnormal airway protection during swallowing using the penetration-aspiration scale. Dysphagia 1999;14:228-32. https://doi.org/10.1007/PL00009610
  44. Grouzmann E, Monod M, Landis B, Wilk S, Brakch N, Nicoucar K, et al. Loss of dipeptidylpeptidase IV activity in chronic rhinosinusitis contributes to the neurogenic inflammation induced by substance P in the nasal mucosa. FASEB J 2002;16:1132-4. https://doi.org/10.1096/fj.01-0939fje
  45. Landis BN, Grouzmann E, Monod M, Busso N, Petak F, Spiliopoulos A, et al. Implication of dipeptidylpeptidase IV activity in human bronchial inflammation and in bronchoconstriction evaluated in anesthetized rabbits. Respiration 2008;75:89-97. https://doi.org/10.1159/000106267
  46. Israili ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology. Ann Intern Med 1992;117:234-42. https://doi.org/10.7326/0003-4819-117-3-234
  47. Lacourciere Y, Brunner H, Irwin R, Karlberg BE, Ramsay LE, Snavely DB, et al. Effects of modulators of the renin-angiotensin-aldosterone system on cough. Losartan Cough Study Group. J Hypertens 1994;12:1387-93.
  48. Dicpinigaitis PV. Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129(1 Suppl):169S-73S. https://doi.org/10.1378/chest.129.1_suppl.169S
  49. Baraniuk JN, Jamieson MJ. Rhinorrhea, cough and fatigue in patients taking sitagliptin. Allergy Asthma Clin Immunol 2010;6:8. https://doi.org/10.1186/1710-1492-6-8
  50. Bryon M, Jaffe A. Disabling cough: habit disorder or tic syndrome? Lancet 2003;361:1991-2. https://doi.org/10.1016/S0140-6736(03)13570-2
  51. Weinberger M. Disabling cough: habit disorder or tic syndrome? Lancet 2003;361:1991. https://doi.org/10.1016/S0140-6736(03)13570-2
  52. Weinberger M. The habit cough syndrome and its variations. Lung 2012;190:45-53. https://doi.org/10.1007/s00408-011-9317-0
  53. Kravitz H, Gomberg RM, Burnstine RC, Hagler S, Korach A. Psychogenic cough tic in children and adolescents. Nine case histories illustrate the need for re-evaluation of this common but frequently unrecognized problem. Clin Pediatr (Phila) 1969;8:580-3. https://doi.org/10.1177/000992286900801009
  54. Gay M, Blager F, Bartsch K, Emery CF, Rosenstiel-Gross AK, Spears J. Psychogenic habit cough: review and case reports. J Clin Psychiatry 1987;48:483-6.
  55. Blager FB, Gay ML, Wood RP. Voice therapy techniques adapted to treatment of habit cough: a pilot study. J Commun Disord 1988;21:393-400. https://doi.org/10.1016/0021-9924(88)90024-X
  56. Cohlan SQ, Stone SM. The cough and the bedsheet. Pediatrics 1984;74:11-5. https://doi.org/10.1542/peds.74.1.11
  57. Birring SS, Kavanagh JE, Irwin RS, Keogh KA, Lim KG, Ryu JH, et al. Treatment of interstitial lung disease associated cough: CHEST Guideline and Expert Panel report. Chest 2018;154:904-17. https://doi.org/10.1016/j.chest.2018.06.038
  58. Tarlo SM, Altman KW, Oppenheimer J, Lim K, Vertigan A, Prezant D, et al. Occupational and environmental contributions to chronic cough in adults: Chest Expert Panel report. Chest 2016;150:894-907. https://doi.org/10.1016/j.chest.2016.07.029
  59. Joint Committee for the Revision of Korean Guidelines for Tuberculosis Korea Centers for Disease Control and Prevention. Korean guidelines for tuberculosis. 4th ed. Seoul: Joint Committee for the Revision of Korean Guidelines for Tuberculosis, Korea Centers for Disease Control and Prevention; 2020.
  60. Kim N, Yi J, Chang CL. Recovery rates of non-tuberculous mycobacteria from clinical specimens are increasing in Korean tertiary-care hospitals. J Korean Med Sci 2017;32:1263-7. https://doi.org/10.3346/jkms.2017.32.8.1263
  61. Ko RE, Moon SM, Ahn S, Jhun BW, Jeon K, Kwon OJ, et al. Changing epidemiology of nontuberculous mycobacterial lung diseases in a tertiary referral hospital in Korea between 2001 and 2015. J Korean Med Sci 2018;33:e65. https://doi.org/10.3346/jkms.2018.33.e65
  62. Lee H, Myung W, Koh WJ, Moon SM, Jhun BW. Epidemiology of nontuberculous mycobacterial infection, South Korea, 2007-2016. Emerg Infect Dis 2019;25:569-72. https://doi.org/10.3201/eid2503.181597
  63. Sundar KM, Daly SE, Pearce MJ, Alward WT. Chronic cough and obstructive sleep apnea in a community-based pulmonary practice. Cough 2010;6:2. https://doi.org/10.1186/1745-9974-6-2
  64. Birring SS, Ing AJ, Chan K, Cossa G, Matos S, Morgan MD, et al. Obstructive sleep apnoea: a cause of chronic cough. Cough 2007;3:7. https://doi.org/10.1186/1745-9974-3-7
  65. Holley JL, Piraino B. CAPD-associated cough. Perit Dial Int 1995;15:392-3. https://doi.org/10.1177/089686089501500426
  66. Min F, Tarlo SM, Bargman J, Poonai N, Richardson R, Oreopoulos D. Prevalence and causes of cough in chronic dialysis patients: a comparison between hemodialysis and peritoneal dialysis patients. Adv Perit Dial 2000;16:129-33.
  67. Tarlo SM. Peritoneal dialysis and cough. Perit Dial Int 2003;23:424-6. https://doi.org/10.1177/089686080302300503
  68. Twardowski ZJ, Khanna R, Nolph KD, Scalamogna A, Metzler MH, Schneider TW, et al. Intraabdominal pressures during natural activities in patients treated with continuous ambulatory peritoneal dialysis. Nephron 1986;44:129-35. https://doi.org/10.1159/000184217
  69. Rosen MJ, Ireland B, Narasimhan M, French C, Irwin RS; CHEST Expert Cough Panel. Cough in ambulatory immunocompromised adults: CHEST Expert Panel report. Chest 2017;152:1038-42. https://doi.org/10.1016/j.chest.2017.07.039
  70. Maschmeyer G, Beinert T, Buchheidt D, Einsele H, Heussel CP, Kiehl M, et al. Diagnosis and antimicrobial therapy of pulmonary infiltrates in febrile neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO). Ann Hematol 2003;82 Suppl 2:S118-26.
  71. Prakash UB. Uncommon causes of cough: ACCP evidencebased clinical practice guidelines. Chest 2006;129(1 Suppl):206S-19S. https://doi.org/10.1378/chest.129.1_suppl.206S
  72. McGarvey LP, Heaney LG, Lawson JT, Johnston BT, Scally CM, Ennis M, et al. Evaluation and outcome of patients with chronic non-productive cough using a comprehensive diagnostic protocol. Thorax 1998;53:738-43. https://doi.org/10.1136/thx.53.9.738
  73. Pratter MR. Unexplained (idiopathic) cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129(1 Suppl):220S-1S. https://doi.org/10.1378/chest.129.1_suppl.220S
  74. Hull JH, Menon A. Laryngeal hypersensitivity in chronic cough. Pulm Pharmacol Ther 2015;35:111-6. https://doi.org/10.1016/j.pupt.2015.08.008
  75. Vertigan AE, Bone SL, Gibson PG. Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome. Respirology 2013;18:948-56. https://doi.org/10.1111/resp.12103
  76. Vertigan AE, Gibson PG, Theodoros DG, Winkworth AL. A review of voice and upper airway function in chronic cough and paradoxical vocal cord movement. Curr Opin Allergy Clin Immunol 2007;7:37-42. https://doi.org/10.1097/ACI.0b013e328012c587
  77. Hull JH, Backer V, Gibson PG, Fowler SJ. Laryngeal dysfunction: assessment and management for the clinician. Am J Respir Crit Care Med 2016;194:1062-72. https://doi.org/10.1164/rccm.201606-1249ci
  78. Blitzer A, Brin MF. Laryngeal dystonia: a series with botulinum toxin therapy. Ann Otol Rhinol Laryngol 1991;100:85-9. https://doi.org/10.1177/000348949110000201
  79. Gibson PG, Ryan NM. Cough pharmacotherapy: current and future status. Expert Opin Pharmacother 2011;12:1745-55. https://doi.org/10.1517/14656566.2011.576249
  80. Bolser DC. Mechanisms of action of central and peripheral antitussive drugs. Pulm Pharmacol 1996;9:357-64. https://doi.org/10.1006/pulp.1996.0047
  81. Balsamo R, Lanata L, Egan CG. Mucoactive drugs. Eur Respir Rev 2010;19:127-33. https://doi.org/10.1183/09059180.00003510
  82. Rogers DF. Mucoactive agents for airway mucus hypersecretory diseases. Respir Care 2007;52:1176-93.