대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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합병증을 동반하지 않은 2형 당뇨병 환자에 대한 백호가인삼탕과 혈당강하제 병행치료의 혈당 강하 효과 및 안전성 연구 : 체계적 문헌 고찰과 메타분석

A Study on the Hypoglycemic Effect and Safety of Combined-Therapy of Baekhogainsam-tang and Hypoglycemic Agent for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis

  • 신재익 (대전대학교 한의과대학 신계내과학교실) ;
  • 백지수 (대전대학교 한의과대학 신계내과학교실) ;
  • 신선미 (세명대학교 한의과대학 신계내과학교실) ;
  • 조충식 (대전대학교 한의과대학 신계내과학교실)
  • Shin, Jae-ik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Baek, Ji-soo (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Shin, Seon-mi (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Cho, Chung-sik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
  • 투고 : 2021.09.15
  • 심사 : 2021.10.06
  • 발행 : 2021.09.30
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초록

Objectives: The purpose of this study is to assess the efficacy and safety of Baekhogainsam-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: For a systematic review and meta-analysis, we set a key question in accordance with PICOT-SD. We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, and ScienceON. A meta-analysis was conducted by synthesizing the results, including fasting plasma glucose level, postprandial 2-hour plasma glucose level, and Glycated Hemoglobin (HbA1c). Results: A total of five trials are included in this systemic review. The treatment group (Baekhogainsam-tang plus conventional treatment) showed more statistically significant effect than did the control group (conventional treatment only) in fasting plasma glucose level, postprandial 2-hour plasma glucose level, and glycated hemoglobin (HbA1c). Conclusions: Baekhogainsam-tang showed statistically significant effects in hypoglycemic effect and in improving insulin resistance. However, the number of studies included in the meta-analysis was insufficient, and the BIT used in the included studies was not standardized. This topic requires further attention and more clinical research.

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과제정보

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0180).

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