The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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The Effect of Sayeok-san for Insomnia: A Systematic Review and Meta-Analysis

사역산(四逆散)의 불면 치료 효과 : 체계적 문헌 고찰 및 메타 분석

  • Huh, Tae-young (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Ha, Da-jung (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Kim, Kyoung-min (Dept. of Korean Internal Medicine, Dong-Eui University)
  • 허태영 (동의대학교 부속 한방병원 한방내과) ;
  • 하다정 (동의대학교 부속 한방병원 한방내과) ;
  • 김경민 (동의대학교 부속 한방병원 한방내과)
  • Received : 2021.08.17
  • Accepted : 2021.10.08
  • Published : 2021.09.30
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Abstract

Objectives: This study evaluated the effectiveness of Sayeok-san for treating insomnia. Methods: We conducted a search using keywords, such as "Sayeoksan", "Si-ni-san", and "insomnia" in eight databases (CNKI, Wanfang, Pubmed, Embase, Cochrane, NDSL, OASIS, RISS) on July 17, 2012. There was no limit placed on the publication period of the papers, and we used Cochrane's risk of bias tool to assess their quality. Meta-analysis was classified according to the outcome measurements, such as total effective rate and PSQI. Results: Nine RCTs were selected. Meta-analysis showed that the treatment group, which used Sayeok-san, had a higher total effective rate than did the control group that used only Western medicine. The treatment group also had a lower average of PSQI and TSS (TCM symptom score) than did the control group. Conclusion: This study suggests that Sayeok-san is effective in treating insomnia. However, these findings should be interpreted cautiously due to unknown or high risk of bias of the included trials.

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