DOI QR코드

DOI QR Code

Investigation of benzimidazole residues in the meat in Sejong area

세종지역 유통 식육 중 벤지미다졸계 구충제 잔류실태 조사

  • Received : 2021.07.13
  • Accepted : 2021.08.23
  • Published : 2021.09.30

Abstract

Benzimidazole is an widely used anthelmintics in livestock clinics. The aim of present study was to investigate benzimidazole residues in the meat in Sejong City. A total of 338 samples of meat(beef 287, pork 37, chicken 14) were selected from the laboratory meat(Korean beef genetic test, hygiene test) supplied to school in Sejong City. Representative benzimidazole class drug such as thiabendazole, 2-amino albendazole sulfone, fenbendazole, oxfendazole, and oxfendazole sulfone were monitored in samples by using lc-ms/ms and the analysis was preformed based on the Korea Food Code guideline. Limit of quantitation (LOQ) was ranged from 0.56 to 3.02 ppb for target drugs and the accuracy was within the acceptance criteria. Among the sample analyzed only one case, the pork meat was found to have drug levels that exceed LOQ. However, the overall residue concentration was 2.17 ppb, which was lower than the maximum residue levels (100 ppb).

Keywords

References

  1. 식품의약품안전처. 2020. 2020년 축산물 안전성 검사계획.
  2. 식품의약품안전처. 2020. 식품공전. 8.3.31.
  3. 식품의약품안전처. 2021. 식품의 기준 및 규격 고시 제2021-26호.
  4. 식품의약품안전평가원. 2018. 식품공전 중 잔류동물용의약품 분석법 개편 연구 12.
  5. 식품의약품평가원. 2015. 의약품 등 시험방법 밸리데이션 가이 드라인 해설서.
  6. Deok Soo Son, Eun Sook Lee, SAmuel E. Adunyah. 2020. The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Network Aug;20(4):e29 doi: 10.4110/in.2020.20.e29.
  7. Eun Young Choi, Heyng Seok Seo, Kui Jeong Baek. Boo Bong Hur, Lee Won Seo, Dong Suk Joung, 2005. Study on analytical method of residual benzimidazole anthelmintics in meat by LC/MS. Korean Journal of Veterinary Service 28(1):81-89.
  8. Furtado LFV, de Paiva Bello ACP, Rabelo EML. 2016. Benzimidazole resistance in helminths: from problem to diagnosis. Acta Trop 162:95-102. https://doi.org/10.1016/j.actatropica.2016.06.021
  9. Geral K. McEvoy, American Society of Health-System Pahmacists. 2006. American Hospital Formulary Service. AHFS Drug Information: Essentials 2006-2007;47.
  10. Guilherme Resende da Silva, Josefa Abucater Lima, Leonardo Francisco de Souza, Flavio Alves Santos, Mary Ane Goncec Lana, Debora Cristina Sampaio de Assis, Silvana de Vasconcelos Cancado. 2017. Multiresidue method for identification and quantification of avermectins, benzimidazoles and nitroimidazoles residues in bovine muscle tissue by ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) using a QuEChERS approach. Talanta 171:307-320. https://doi.org/10.1016/j.talanta.2017.05.012
  11. John B. Sullivan. 1992. Clinical Principles of Environmental Health. pp. 1072. In: Gray R. Krieger(ed.). Hazardous Materials Toxicology. Williams&Wilkins. Philadelphia.
  12. Hyung Joo Kang, Mun Bae Kim, Jae Bong Lee, Bong Sik Kim, Young Kab Kim. 2003. Analysis for benzimidazoles in eggs. Korean Journal of Veterinary Service 26(2):157-162.
  13. Kyung Jin Lee, Young Woon Kang, Eungui Kang, Miran Kim, Kyeong Nyeo Bahn, Young Mi Jang, Meehye Kim. 2010. Determination of Benzimidazole Residues in Livestock Products. Food science and biotechnology 42(5):515-520
  14. T.D. Waal, M. Danaher. 2014. Veterinary Drugs Residues: Control of Helminths. Encylclopedia of Food Safety Vol 3: 81-85. doi: 10.1016/B978-0-12-378612-8.00249-3.
  15. Young Min Lee, Kyung Duk Zoh. 2016. Recent analysis of drug residues in food, The Korean Journal of Public Health 53(1):27-37. https://doi.org/10.17262/KJPH.2016.03.53.1.27