Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of marbofloxacin injection for granuloma formation in fattening pigs

마보플록삭신 제품별 접종이 비육돈 목심 부위 이상육 발생에 미치는 효과

  • Im, Chang-Won (Laboratory of Veterinary Bacteriology, College of Veterinary Medicine, Chungbuk National University) ;
  • Lee, Wan-Kyu (Laboratory of Veterinary Bacteriology, College of Veterinary Medicine, Chungbuk National University)
  • 임창원 (충북대학교 수의과대학 수의세균학 연구실) ;
  • 이완규 (충북대학교 수의과대학 수의세균학 연구실)
  • Received : 2021.07.15
  • Accepted : 2021.09.13
  • Published : 2021.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The abnormal meat could caused by abscess, fibrosis and granuloma in the region of the neck by adverse effect of vaccination or antibiotic injection under swine practice. In this study, the incidence of abnormal meat due to antibiotics injection was investigated using marbofloxacin from different manufacturers. To evaluate the incidence of abnormal meat via antibiotic treatment, a total of 440 pigs with the age of 140~150 days old were selected. Two hundred of pigs were assigned as a control group and 2 mL of saline was inoculated daily for three days. Two hundred forty of pigs were used as treatment group and further divided into 6 groups, consisting of 16% of original marbofloxacin treated, 10% of original marbofloxacin treated and 4 different kinds of generic marbofloxacin treated groups respectively. When test animals were slaughtered, incidence, type and size of induced abnormal meat were recorded. In the result of this study, statistical analysis found significantly lower incidence of abnormal meat formation was in 16% original marbofloxacin treated groups compared to the other tested groups (P<0.05). In the summary, antibiotic treatment could produce abnormal meat formation but the 16% of original marbofloxacin had the most minimal abnormal meat formation effect.

Keywords

Acknowledgement

본 결과물은 농림축산식품부의 재원으로 농림식품기술기획평가원의 농식품기술융합창의인재양성사업의 지원을 받아 연구되었음(과제번호: 320005-4).

References

  1. Anna R, James A. 2003. Adjuvants in veterinary vaccines: Modes of action and adverse effects. J Vet Intern Med 17: 273-281. https://doi.org/10.1111/j.1939-1676.2003.tb02448.x
  2. Applbaum PC, Hunter PA. 2000. The fluoroquinolone antibacterials: past, present and future perspective. Int J Antimicrob Agents 16: 5-15 https://doi.org/10.1016/S0924-8579(00)00192-8
  3. Bryce M, Terry A, Larry C, Michael D, Jerome C, James J, Gary A, Brandon L. 2012. Incidence and severity of Arcanobacterium pyogenes injection site abscesses with needle or needle-free injection. Meat Science 92: 805-807. https://doi.org/10.1016/j.meatsci.2012.07.004
  4. Choi SH, Pak SI. 2015. Economic burden of foot-and-mouth disease vaccination induced injection site lesions in slaughtered pigs and its causal relationship. J Prev Med Public Heath 39:153-156.
  5. Christensen G, Sorensen V, Mousing J. 1999. Disease of the respiratory system. Disease of Swine. pp. 913-940.
  6. Dubeski P, Aalhus J, Donkersgoed J, Vanderkop M. 2001. Tenderness of beef round muscles containing injection site lesions or bruises. Can J Anim Sci. 81: 441-449. https://doi.org/10.4141/A00-076
  7. Dudley MN. 1991. Pharmacodynamics and pharmacokinetics of antibiotics with special references to the fluoroquinolones. Am J Med 30: 45-50.
  8. Eun Young Ko, Samooel Jung, Hyun Kyu Jeong. 2018. Effects of Foot-and-mouth Disease Vaccination location and injection device on the incidence of site lesion in pork. Korean J Food Sci Anim Resour 38(3): 498-505. https://doi.org/10.5851/KOSFA.2018.38.3.498
  9. George M, Heinrich P, Dexter D, Morgan J, Odde K, Glock R. 1995. Injection-site lesions in carcasses of cattle receiving injections at branding and at weaning. J Anim Sci 73: 3235-3240. https://doi.org/10.2527/1995.73113235x
  10. Harper A. 2008. Injection use and quality assured pork. Livestock update. Virginia Cooperative Extension.
  11. Kahn C, Line S. 2005. The Merk Veterinary Manual. (9th ed.). New jersey: Merck Sharp & Dohme Corp. pp. 935-953.
  12. Lefebre H, Laroute V, et al. 1996. Non-invasive and quantitative evaluation of post-injection muscle damage by pharmacokinetic analysis of creatine kinase release. Vet Res 27: 343-361.
  13. Nouws JFM. 1984. Irritation, bioavailability, and residue aspects of ten oxytetracycline formulations adiministered intramuscularly to pigs. Vet Quart 6: 80-84. https://doi.org/10.1080/01652176.1984.9693916
  14. Nouws, Smulders, Rappalini. 1990. A comparative study on irritation and residue aspects of five oxytetracycline formulations administered intramuscularly to calves, pigs and sheep. Vet Quart 12: 129-138. https://doi.org/10.1080/01652176.1990.9694257
  15. Otake S, Dee SA, Rossow KD, Joo HS, Deen J, Molitor TW, Pijoan C. 2002. Transmission of porcine reproductive and respiratory syndrome virus by needles. Vet Rec 150: 114-115. https://doi.org/10.1002/j.2042-7670.2002.tb23931.x
  16. Thomas E, Caldow GL, Borrell D, Davot JL. 2001. A field comparison of the efficacy and tolerance of marbofloxacin in the treatment of bovine respiratory disease. J Vet Pharmacol 24: 353-358. https://doi.org/10.1046/j.1365-2885.2001.00333.x
  17. Trinh H, Billington S, Field A, Songer J, Jost B. 2002. Susceptibility of Arcanobacterium pyogenes from different sources to tetracycline, macrolide and lincosamide antimicrobial agent. Vet Microbiol 85: 353-359. https://doi.org/10.1016/S0378-1135(01)00524-7
  18. Valtulini S, Macchi C, Ballanti P, Cherel Y, Laval A, Theaker JM, Bak M, Ferretti E, Morvan H. 2005. Aluminium hydroxide-induced granulomas in pigs. Vaccine 23: 3999-4004. https://doi.org/10.1016/j.vaccine.2004.06.058
  19. Yu-Ri Park, Da-Rae Lim, Hye-Ryung Kim, Min-Ji Park, Bumseok Kim, Won-Il Kim, Chang-Ho Hong, Sung-Nyon Kim, Choi-Kyu Park. 2017. Evaluation of efficacy of a commercial vaccine stress-relieving agent to reduce the adverse effects of foot-andmouth disease vaccination site in pig. Kor J Vet Serv 40(3): 177-185. https://doi.org/10.7853/kjvs.2017.40.3.177