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안저 출혈 시 형광안저혈관조영술 및 대체 검사의 유용성

The Usefulness of Fluorescein Angiography and Alternative Tests for Assessment of Fundus Hemorrhage

  • 연제진 (분당서울대학교병원 안과) ;
  • 구본경 (삼성서울병원 진단검사의학과) ;
  • 박상구 (건국대학교병원 신경외과)
  • Yeon, Je-Jin (Department of Ophthalmology, Seoul National University Bundang Hospital) ;
  • Koo, Bon-Kyeong (Department of Laboratory Medicine, Samsung Medical Center) ;
  • Park, Sang-Ku (Department of Neurosurgery, Konkuk University Medical Center)
  • 투고 : 2021.06.11
  • 심사 : 2021.06.21
  • 발행 : 2021.09.30

초록

안저 출혈은 망막 조직과 혈관의 이상을 의미한다. 따라서 안과 의사는 안저의 출혈성 변화가 발생하면 이에 따른 치료 계획을 수립하기 위해 치료 전과 치료 중간, 치료 이후 등 병변의 진행상황을 파악하기 위해 여러 가지 안과 검사의 출혈 성 정도의 평가를 위해 오더를 지시한다. 현재 가장 유용하고 보편적인 안저검사에는 빛간섭단층촬영(OCT), 안저촬영(FP), 형광안저혈관조영술(FAG) 등이 있다. 중증 안저 출혈에 대한 치료 계획을 수립하기 위한 기존의 형광안저혈관조영술 검사에는 한계가 있다. 저자들은 광각형광혈관조영술을 이용하여 동공주위촬영과 5-quadrant 방법을 수행할 것을 제안한다. 이 방법을 사용하면 신속히 검사 부위를 결정하고 최대한 출혈의 반경을 피해 안과 의사에게 손상된 조직과 이상 혈관의 범위를 제공할 수 있다. 그런데도 불구하고 안과 의사가 안저 출혈이 매우 심각하여 광각형광혈관조영술이 무의미하다고 판단하는 경우가 있다. 이런 경우 대체검사로 안과초음파 및 망막전위도의 오더가 발생한다. 따라서 우리는 안 초음파 및 망막전위도 검사 필요성에 대해 당위성을 인정해야 하고, 정확하게 수행해야 한다.

Fundus hemorrhage refers to abnormalities in the retinal tissue and blood vessels. Therefore, when a hemorrhagic change in the fundus occurs, the ophthalmologist orders various ophthalmic tests to evaluate the degree of hemorrhage and determine the progress of the lesion before, during, and after treatment to accordingly establish a treatment plan. Currently, the most useful and universal fundus examination includes optical coherence tomography (OCT), fundus photography (FP), and fluorescein angiography (FAG). Existing fluorescein angiography test methods for establishing a treatment plan for severe fundus bleeding have limitations. The authors propose that peripheral pupil and the 5-quadrant method should be performed using ultra-wide-angle fluorescence fundus angiography (UWFFA). Using this method, it is possible to quickly determine the area to be described, avoid the radius of bleeding as much as possible, and provide the ophthalmologist with a range of damaged tissue and abnormal blood vessels. Nevertheless, there are cases in which ophthalmologists judge that fundus bleeding is so severe that ultra-wide-angle fluorescence fundus angiography is meaningless. In such cases, ophthalmic ultrasound and electroretinogram may be used in that order as alternative methods of examination. Therefore, some clinical situations require the use of ophthalmic ultrasound and electroretinogram and should be performed accurately.

키워드

참고문헌

  1. Lee HS, Choi HS, Kwon OY. A literature review on ba1ance control factors. Physical Therapy Korea. 1996;3:82-91.
  2. Bae SH, Cho BL, Son KY, Han MK, Kim MK, Han NR, et al. Interpretation of ophthalmoscopy. Korean J Fam Pract. 2013;3:415-421.
  3. Novotny HR, Alvis DL. A method of photographing fluorescein circulating blood in the human retina. Circulation. 1961;24: 82-86. https://doi.org/10.1161/01.cir.24.1.82
  4. Yang YS, Kang P, Hwang JY, Kim JD. A study on microcirculation time including retinal periphery in diabetic retinopathy using the fluorescein angiography. J Korean Ophthalmol Soc. 2000;41:931-937.
  5. Sinclair SH. Macular retinal capillary hemodynamics in diabetic patients. Ophthalmology. 1991;98:1580-1586. https://doi.org/10.1016/s0161-6420(91)32084-0
  6. Wolf S, Arend O, Toonen H, Bertram B, Jung F, Reim M. Retinal capillary blood flow measurement with a scanning laser ophthalmoscope preliminary results. Ophthalmology. 1991;98:996-1000. https://doi.org/10.1016/s0161-6420(91)32192-4
  7. Guillermo SV, Manuel TA, Catalina BR, Estefania IE, Mariana M, Raul VM, et al. A proposed method to quantify vitreous hemorrhage by ultrasound. Clin Ophthalmol. 2019;13:2377-2384. https://doi.org/10.2147/OPTH.S229857
  8. Fekih O, Abdeljelil A, Zgolli H, Nacef L. Vitreous hemorrhage secondary to sickle cell trait. J Fr Ophtalmol. 2020;43:147-149. https://doi.org/10.1016/j.jfo.2019.09.007
  9. Shukla UV, Kaufman EK. Intraocular hemorrhage. Treasure island: Stat Pearls Publishing; 2021.
  10. Butner RW, McPherson AR. Spontaneous vitreous hemorrhage. Ann Ophthalmol. 1982;14:268-270.
  11. Dana MR, Werner MS, Viana MA, Shapiro MJ. Spontaneous and traumatic vitreous hemorrhage. Ophthalmology. 1993;100:1377-1383. https://doi.org/10.1016/s0161-6420(93)31472-7
  12. Lean JS, Gregor Z. The acute vitreous hemorrhage. Br J Ophthalmol. 1980;64:469-471. https://doi.org/10.1136/bjo.64.7.469
  13. Lindgren G, Sjodell L, Lindblom B. A prospective study of dense spontaneous vitreous hemorrhage. Am J Ophthalmol. 1995; 119:458-465. https://doi.org/10.1016/s0002-9394(14)71232-2
  14. Spraul CW, Grossniklaus HE. Vitreous hemorrhage. Surv Ophthalmol. 1997;42:3-39. https://doi.org/10.1016/s0039-6257(97)84041-6
  15. Lee JH. Differential diagnosis by fundus examination. Seoul: Seoul National University Publishing; 1997. p41-46.
  16. Liebrerman RM, Gow JA, Grillone LR. Development and implementation of a vitreous hemorrhage grading scale 2006 [Internet]. Doylestown, PA: Penta Vision; 2021 [cited 2021 Jun 08]. Available from: https://www.retinalphysician.com/issues/2006/may-2006/development-and-implementation-of-a-vitreous-hemor
  17. Korean Ophthalmological Society. Ohthalmic examination. Seoul: Korean Ophthalmological Society; 2002. p277-281
  18. Hood DC, Bach M, Brigell M, Keating D, Kondo M, Lyons JS, et al. ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc Ophthalmol. 2012;124:1-13. https://doi.org/10.1007/s10633-011-9296-8