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Anti-Myelin Oligodendrocyte Glycoprotein Syndrome with Findings Resembling "Snake-Eye Appearance": a Case Report

  • Hong, Sujin (Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Yi, Jisook (Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Lee, Ho-joon (Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Hahn, Seok (Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Lim, Yun-jung (Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Lee, Yedaun (Department of Radiology, Haeundae Paik Hospital, Inje University College of Medicine) ;
  • Shin, Kyong Jin (Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine)
  • Received : 2021.03.25
  • Accepted : 2021.06.17
  • Published : 2021.09.30

Abstract

Anti-myelin oligodendrocyte glycoprotein (anti-MOG) syndrome is an immune-mediated inflammatory condition of the central nervous system, which usually involves spinal cord and optic nerves. Herein, we studied the case of a 57-year-old female patient who presented with acute/subacute symptoms of sphincter dysfunction, paraparesis, and ocular pain. The patient was diagnosed with anti-MOG syndrome with findings resembling snake-eye appearance (SEA), characterized by nearly symmetrical round high signal intensity lesions located at anterior horns (gray matter) on T2-weighted image.

Keywords

References

  1. Zhang Z, Wang H. Is the "snake-eye" MRI sign correlated to anterior spinal artery occlusion on CT angiography in cervical spondylotic myelopathy and amyotrophy? Eur Spine J 2014;23:1541-1547 https://doi.org/10.1007/s00586-014-3348-1
  2. Zalewski NL, Rabinstein AA, Krecke KN, et al. Characteristics of spontaneous spinal cord infarction and proposed diagnostic criteria. JAMA Neurol 2019;76:56-63 https://doi.org/10.1001/jamaneurol.2018.2734
  3. Lana-Peixoto MA, Talim N. Neuromyelitisoptica spectrum disorder and anti-MOG syndromes. Biomedicines 2019;7:42 https://doi.org/10.3390/biomedicines7020042
  4. Deneve M, Biotti D, Patsoura S, et al. MRI features of demyelinating disease associated with anti-MOG antibodies in adults. J Neuroradiol 2019;46:312-318 https://doi.org/10.1016/j.neurad.2019.06.001
  5. Shor N, Deschamps R, Cobo Calvo A, et al. MRI characteristics of MOG-Ab associated disease in adults: an update. Rev Neurol (Paris) 2021;177:39-50 https://doi.org/10.1016/j.neurol.2020.06.016
  6. Chiriboga SL, Flanagan EP. Myelitis and other autoimmune myelopathies. Continuum (Minneap Minn). 2021;27:62-92
  7. Dobson R, Ramagopalan S, Davis A, Giovannoni G. Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude. J Neurol Neurosurg Psychiatry 2013;84:909-914 https://doi.org/10.1136/jnnp-2012-304695
  8. Krampla W, Aboul-Enein F, Jecel J, et al. Spinal cord lesions in patients with neuromyelitis optica: a retrospective long-term MRI follow-up study. Eur Radiol 2009;19:2535-2543 https://doi.org/10.1007/s00330-009-1425-3
  9. Kim YJ, Hwang HR. Clustering effects of metabolic factors and the risk of metabolic syndrome. J Obes Metab Syndr 2018;27:166-174 https://doi.org/10.7570/jomes.2018.27.3.166
  10. Ciccarelli O, Cohen JA, Reingold SC, et al. Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders. Lancet Neurol 2019;18:185-197 https://doi.org/10.1016/S1474-4422(18)30460-5