과제정보
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A5A2019413) and by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number : HI20C1205).
참고문헌
- Lechien JR, Saussez S, Schindler A, Karkos PD, Hamdan AL, Harmegnies B, et al. Clinical outcomes of laryngopharyngeal reflux treatment: A systematic review and meta-analysis. Laryngoscope 2019;129(5):1174-87. https://doi.org/10.1002/lary.27591
- Koufman JA, Aviv JE, Casiano RR, Shaw GY. Laryngopharyngeal reflux: Position statement of the committee on speech, voice, and swallowing disorders of the American Academy of Otolaryngology-Head and Neck Surgery. Otolaryngol Head Neck Surg 2002;127(1):32-5. https://doi.org/10.1067/mhn.2002.125760
- Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, et al. Airway reflux. Ann N Y Acad Sci 2016;1381(1):5-13. https://doi.org/10.1111/nyas.13080
- Sereg-Bahar M, Jerin A, Jansa R, Stabuc B, Hocevar-Boltezar I. Pepsin and bile acids in saliva in patients with laryngopharyngeal reflux - a prospective comparative study. Clin Otolaryngol 2015;40(3):234-9. https://doi.org/10.1111/coa.12358
- Amarasiri DL, Pathmeswaran A, de Silva HJ, Ranasinha CD. Response of the airways and autonomic nervous system to acid perfusion of the esophagus in patients with asthma: A laboratory study. BMC Pulm Med 2013;13:33. https://doi.org/10.1186/1471-2466-13-33
- Lechien JR, Saussez S, Karkos PD. Laryngopharyngeal reflux disease: Clinical presentation, diagnosis and therapeutic challenges in 2018. Curr Opin Otolaryngol Head Neck Surg 2018;26(6):392-402. https://doi.org/10.1097/moo.0000000000000486
- Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): A clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope 1991;101(S53):1-78. https://doi.org/10.1002/lary.1991.101.s53.1
- Chen XM, Li Y, Guo WL, Wang WT, Lu M. Prevalence of laryngopharyngeal reflux disease in Fuzhou region of China. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2016;51(12):909-13.
- Spantideas N, Drosou E, Bougea A, Assimakopoulos D. Laryngopharyngeal reflux disease in the Greek general population, prevalence and risk factors. BMC Ear Nose Throat Disord 2015;15:7. https://doi.org/10.1186/s12901-015-0020-2
- Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 2000;123(4):385-8. https://doi.org/10.1067/mhn.2000.109935
- Lechien JR, Finck C, Khalife M, Huet K, Delvaux V, Picalugga M, et al. Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease. Clin Otolaryngol 2018;43(5):1273-82. https://doi.org/10.1111/coa.13140
- Lee YS, Choi SH, Son YI, Park YH, Kim SY, Nam SY. Prospective, observational study using rabeprazole in 455 patients with laryngopharyngeal reflux disease. Eur Arch Otorhinolaryngol 2011;268(6):863-9. https://doi.org/10.1007/s00405-010-1475-9
- Habermann W, Schmid C, Neumann K, Devaney T, Hammer HF. Reflux symptom index and reflux finding score in otolaryngologic practice. J Voice 2012;26(3):e123-7.
- Jaspersen D, Kulig M, Labenz J, Leodolter A, Lind T, Meyer-Sabellek W, et al. Prevalence of extra-oesophageal manifestations in gastrooesophageal reflux disease: An analysis based on the ProGERD Study. Aliment Pharmacol Ther 2003;17(12):1515-20. https://doi.org/10.1046/j.1365-2036.2003.01606.x
- Dore MP, Pedroni A, Pes GM, Maragkoudakis E, Tadeu V, Pirina P, et al. Effect of antisecretory therapy on atypical symptoms in gastroesophageal reflux disease. Dig Dis Sci 2007;52(2):463-8. https://doi.org/10.1007/s10620-006-9573-7
- Fuchs HF, Muller DT, Berlth F, Maus MK, Fuchs C, Dubbers M, et al. Simultaneous laryngopharyngeal pH monitoring (Restech) and conventional esophageal pH monitoring-correlation using a large patient cohort of more than 100 patients with suspected gastroesophageal reflux disease. Dis Esophagus 2018;31(10):1-8.
- Drinnan M, Powell J, Nikkar-Esfahani A, Heading RC, Doyle J, Griffin SM, et al. Gastroesophageal and extraesophageal reflux symptoms: similarities and differences. Laryngoscope 2015;125(2):424-30. https://doi.org/10.1002/lary.24950
- Nason KS, Murphy T, Schindler J, Schipper PH, Hoppo T, Diggs BS, et al. A cross-sectional analysis of the prevalence of Barrett esophagus in otolaryngology patients with laryngeal symptoms. J Clin Gastroenterol 2013;47(9):762-8. https://doi.org/10.1097/MCG.0b013e318293d522
- Mosli M, Alkhathlan B, Abumohssin A, Merdad M, Alherabi A, Marglani O, et al. Prevalence and clinical predictors of LPR among patients diagnosed with GERD according to the reflux symptom index questionnaire. Saudi J Gastroenterol 2018;24(4):236-41. https://doi.org/10.4103/sjg.sjg_518_17
- Chen M, Hou C, Chen T, Lin Z, Wang X, Zeng Y. Reflux symptom index and reflux finding score in 91 asymptomatic volunteers. Acta Otolaryngol 2018;138(7):659-63. https://doi.org/10.1080/00016489.2018.1436768
- Gao CK, Li YF, Wang L, Han XY, Wu T, Zeng FF, et al. Different cutoffs of the reflux finding score for diagnosing laryngopharyngeal reflux disease should be used for different genders. Acta Otolaryngol 2018;138(9):848-54. https://doi.org/10.1080/00016489.2018.1473642
- Mendelsohn AH. The effects of reflux on the elderly: The problems with medications and interventions. Otolaryngol Clin North Am 2018;51(4):779-87. https://doi.org/10.1016/j.otc.2018.03.007
- Lechien JR, Finck C, Huet K, Khalife M, Fourneau AF, Delvaux V, et al. Impact of age on laryngopharyngeal reflux disease presentation: A multi-center prospective study. Eur Arch Otorhinolaryngol 2017;274(10):3687-96. https://doi.org/10.1007/s00405-017-4671-z
- Hicks DM, Ours TM, Abelson TI, Vaezi MF, Richter JE. The prevalence of hypopharynx findings associated with gastroesophageal reflux in normal volunteers. J Voice 2002;16(4):564-79. https://doi.org/10.1016/S0892-1997(02)00132-7
- Chang BA, MacNeil SD, Morrison MD, Lee PK. The reliability of the reflux finding score among general otolaryngologists. J Voice 2015;29(5):572-7. https://doi.org/10.1016/j.jvoice.2014.10.009
- Musser J, Kelchner L, Neils-Strunjas J, Montrose M. A comparison of rating scales used in the diagnosis of extraesophageal reflux. J Voice 2011;25(3):293-300. https://doi.org/10.1016/j.jvoice.2009.11.009
- Lechien JR, Schindler A, De Marrez LG, Hamdan AL, Karkos PD, Harmegnies B, et al. Instruments evaluating the clinical findings of laryngopharyngeal reflux: A systematic review. Laryngoscope 2019; 129(3):720-36. https://doi.org/10.1002/lary.27537
- Lechien JR, Saussez S, Harmegnies B, Finck C, Burns JA. Laryngopharyngeal reflux and voice disorders: A multifactorial model of etiology and pathophysiology. J Voice 2017;31(6):733-52. https://doi.org/10.1016/j.jvoice.2017.03.015
- Wood JM, Hussey DJ, Woods CM, Astill D, I Watson D, Lee B, et al. Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls? Clin Otolaryngol 2018;43(1):158-63. https://doi.org/10.1111/coa.12918
- Ali Mel-S, Bulmer DM, Dettmar PW, Pearson JP. Mucin gene expression in reflux laryngeal mucosa: Histological and in situ hybridization observations. Int J Otolaryngol 2014;2014:264075.
- Hanson DG, Jiang J, Chi W. Quantitative color analysis of laryngeal erythema in chronic posterior laryngitis. J Voice 1998;12(1):78-83. https://doi.org/10.1016/S0892-1997(98)80077-5
- Arruda Henry MA, Martins RH, Lerco MM, Carvalho LR, Lamonica-Garcia VC. Gastroesophageal reflux disease and vocal disturbances. Arq Gastroenterol 2011;48(2):98-103. https://doi.org/10.1590/S0004-28032011000200003
- Jin BJ, Lee YS, Jeong SW, Jeong JH, Lee SH, Tae K. Change of acoustic parameters before and after treatment in laryngopharyngeal reflux patients. Laryngoscope 2008;118(5):938-41. https://doi.org/10.1097/MLG.0b013e3181651c3a
- Ramirez DAM, Jimenez VMV, Lopez XH, Ysunza PA. Acoustic analysis of voice and electroglottography in patients with laryngopharyngeal reflux. J Voice 2018;32(3):281-4. https://doi.org/10.1016/j.jvoice.2017.05.009
- Doo JG, Kim SI, Park JM, Kwon OE, Lee YC, Eun YG. Changes in pharyngeal baseline impedance in patients with laryngopharyngeal reflux. Otolaryngol Head Neck Surg 2020;163(3):563-8. https://doi.org/10.1177/0194599820918820
- Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16(2):274-7. https://doi.org/10.1016/S0892-1997(02)00097-8
- Carrau RL, Khidr A, Gold KF, Crawley JA, Hillson EM, Koufman JA, et al. Validation of a quality-of-life instrument for laryngopharyngeal reflux. Arch Otolaryngol Head Neck Surg 2005;131(4):315-20. https://doi.org/10.1001/archotol.131.4.315
- Lechien JR, Schindler A, Hamdan AL, Bobin F, Barillari MR, Harmegnies B, et al. The development of new clinical instruments in laryngopharyngeal reflux disease: The international project of young otolaryngologists of the International Federation of Oto-rhino-laryngological Societies. Eur Ann Otorhinolaryngol Head Neck Dis 2018;135(5S):S85-91. https://doi.org/10.1016/j.anorl.2018.05.013
- Lechien JR, Bobin F, Muls V, Thill MP, Horoi M, Ostermann K, et al. Validity and reliability of the reflux symptom score. Laryngoscope 2020;130(3):E98-107.
- Galli J, Cammarota G, De Corso E, Agostino S, Cianci R, Almadori G, et al. Biliary laryngopharyngeal reflux: A new pathological entity. Curr Opin Otolaryngol Head Neck Surg 2006;14(3):128-32. https://doi.org/10.1097/01.moo.0000193198.40096.be
- Lee JS, Jung AR, Park JM, Park MJ, Lee YC, Eun YG. Comparison of characteristics according to reflux type in patients with laryngopharyngeal reflux. Clin Exp Otorhinolaryngol 2018;11(2):141-5. https://doi.org/10.21053/ceo.2017.00577
- Kim SI, Kwon OE, Na SY, Lee YC, Park JM, Eun YG. Association between 24-hour combined multichannel intraluminal impedance-pH monitoring and symptoms or quality of life in patients with laryngopharyngeal reflux. Clin Otolaryngol 2017;42(3):584-91. https://doi.org/10.1111/coa.12817
- Hoppo T, Sanz AF, Nason KS, Carroll TL, Rosen C, Normolle DP, et al. How much pharyngeal exposure is "normal"? Normative data for laryngopharyngeal reflux events using hypopharyngeal multichannel intraluminal impedance (HMII). J Gastrointest Surg 2012;16(1):16-24; discussion 24-5. https://doi.org/10.1007/s11605-011-1741-1
- Maldonado A, Diederich L, Castell DO, Gideon RM, Katz PO. Laryngopharyngeal reflux identified using a new catheter design: Defining normal values and excluding artifacts. Laryngoscope 2003;113:349-55. https://doi.org/10.1097/00005537-200302000-00027
- Jacob P, Kahrilas PJ, Herzon G. Proximal esophageal pH-metry in patients with 'reflux laryngitis'. Gastroenterology 1991;100(2):305-10. https://doi.org/10.1016/0016-5085(91)90196-R
- Eubanks TR, Omelanczuk PE, Maronian N, Hillel A, Pope CE 2nd, Pellegrini CA. Pharyngeal pH monitoring in 222 patients with suspected laryngeal reflux. J Gastrointest Surg 2001;5(2):183-90; discussion 190-1. https://doi.org/10.1016/s1091-255x(01)80032-9
- Gupta R, Sataloff RT. Laryngopharyngeal reflux: Current concepts and questions. Curr Opin Otolaryngol Head Neck Surg 2009;17(3):143-8. https://doi.org/10.1097/MOO.0b013e32832b2581
- Chander B, Hanley-Williams N, Deng Y, Sheth A. 24 versus 48-hour bravo pH monitoring. J Clin Gastroenterol 2012;46(3):197-200. https://doi.org/10.1097/MCG.0b013e31822f3c4f
- Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA 2005;294(12):1534-40. https://doi.org/10.1001/jama.294.12.1534
- Gupta N, Green RW, Megwalu UC. Evaluation of a laryngopharyngeal reflux management protocol. Am J Otolaryngol 2016;37(3):245-50. https://doi.org/10.1016/j.amjoto.2016.01.008
- Gyawali CP, Kahrilas PJ, Savarino E, Zerbib F, Mion F, Smout AJPM, et al. Modern diagnosis of GERD: The Lyon Consensus. Gut 2018;67(7):1351-62. https://doi.org/10.1136/gutjnl-2017-314722
- Lien HC, Wang CC, Lee SW, Hsu JY, Yeh HZ, Ko CW, et al. Responder definition of a patient-reported outcome instrument for laryngopharyngeal reflux based on the US FDA guidance. Value Health 2015;18(4):396-403. https://doi.org/10.1016/j.jval.2015.01.001
- Masaany M, Marina MB, Sharifa Ezat WP, Sani A. Empirical treatment with pantoprazole as a diagnostic tool for symptomatic adult laryngopharyngeal reflux. J Laryngol Otol 2011;125(5):502-8. https://doi.org/10.1017/S0022215111000120
- Lechien JR, Huet K, Khalife M, Fourneau AF, Delvaux V, Piccaluga M, et al. Impact of laryngopharyngeal reflux on subjective and objective voice assessments: A prospective study. J Otolaryngol Head Neck Surg 2016;45(1):59. https://doi.org/10.1186/s40463-016-0171-1
- Piper DW, Fenton BH. pH stability and activity curves of pepsin with special reference to their clinical importance. Gut 1965;6(5):506-8. https://doi.org/10.1136/gut.6.5.506
- Jung AR, Kwon OE, Park JM, Dong SH, Jung SY, Lee YC, et al. Association between pepsin in the saliva and the subjective symptoms in patients with laryngopharyngeal reflux. J Voice 2019;33(2):150-4. https://doi.org/10.1016/j.jvoice.2017.10.015
- Wang J, Zhao Y, Ren J, Xu Y. Pepsin in saliva as a diagnostic biomarker in laryngopharyngeal reflux: A meta-analysis. Eur Arch Otorhinolaryngol 2018;275(3):671-8. https://doi.org/10.1007/s00405-017-4845-8
- Wassenaar E, Johnston N, Merati A, Montenovo M, Petersen R, Tatum R, et al. Pepsin detection in patients with laryngopharyngeal reflux before and after fundoplication. Surg Endosc 2011;25:3870-6. https://doi.org/10.1007/s00464-011-1813-z
- Saritas Yuksel E, Hong SK, Strugala V, Slaughter JC, Goutte M, Garrett CG, et al. Rapid salivary pepsin test: Blinded assessment of test performance in gastroesophageal reflux disease. Laryngoscope 2012;122(6):1312-6. https://doi.org/10.1002/lary.23252
- Klimara MJ, Johnston N, Samuels TL, Visotcky AM, Poetker DM, Loehrl TA, et al. Correlation of salivary and nasal lavage pepsin with MII-pH testing. Laryngoscope 2020;130(4):961-6. https://doi.org/10.1002/lary.28182
- Na SY, Kwon OE, Lee YC, Eun YG. Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux. Laryngoscope 2016;126(12):2770-3. https://doi.org/10.1002/lary.26018
- Weitzendorfer M, Antoniou SA, Schredl P, Witzel K, Weitzendorfer IC, Majerus A, et al. Pepsin and oropharyngeal pH monitoring to diagnose patients with laryngopharyngeal reflux. Laryngoscope 2020;130(7):1780-6. https://doi.org/10.1002/lary.28320
- Fortunato JE, D'Agostino RB Jr, Lively MO. Pepsin in saliva as a biomarker for oropharyngeal reflux compared with 24-hour esophageal impedance/pH monitoring in pediatric patients. Neurogastroenterol Motil 2017;29(2):e12936. https://doi.org/10.1111/nmo.12936
- Lee YC, Lee JS, Kim SW, Kwon KH, Eun YG. Influence of age on treatment with proton pump inhibitors in patients with laryngopharyngeal reflux disease: A prospective multicenter study. JAMA Otolaryngol Head Neck Surg 2013;139(12):1291-5. https://doi.org/10.1001/jamaoto.2013.5556
- Kroch DA, Madanick RD. Medical treatment of gastroesophageal reflux disease. World J Surg 2017;41(7):1678-84. https://doi.org/10.1007/s00268-017-3954-2
- Zalvan CH, Hu S, Greenberg B, Geliebter J. A comparison of alkaline water and Mediterranean diet vs proton pump inhibition for treatment of laryngopharyngeal reflux. JAMA Otolaryngol Head Neck Surg 2017;143(10):1023-9. https://doi.org/10.1001/jamaoto.2017.1454
- Koufman JA. Low-acid diet for recalcitrant laryngopharyngeal reflux: Therapeutic benefits and their implications. Ann Otol Rhinol Laryngol 2011;120(5):281-7. https://doi.org/10.1177/000348941112000501
- Lechien JR, Huet K, Khalife M, De Marrez LG, Finck C, Harmegnies B, et al. Alkaline, protein, low-fat and low-acid diet in laryngopharyngeal reflux disease: Our experience on 65 patients. Clin Otolaryngol 2019;44(3):379-84. https://doi.org/10.1111/coa.13269
- Yang J, Dehom S, Sanders S, Murry T, Krishna P, Crawley BK. Treating laryngopharyngeal reflux: Evaluation of an anti-reflux program with comparison to medications. Am J Otolaryngol 2018;39(1):50-5. https://doi.org/10.1016/j.amjoto.2017.10.014
- Pisegna JM, Yang S, Purcell A, Rubio A. A mixed-methods study of patient views on reflux symptoms and medication routines. J Voice 2017;31(3):381.e15-381.e25.
- Lee YC, Jung AR, Kwon OE, Kang JW, Huh JH, Eun YG. The effect of baclofen combined with a proton pump inhibitor in patients with refractory laryngopharyngeal reflux: A prospective, open-label study in thirty-two patients. Clin Otolaryngol 2019;44(3):431-4. https://doi.org/10.1111/coa.13297
- Mazzini Gda S, Gurski RR. Impact of laparoscopic fundoplication for the treatment of laryngopharyngeal reflux: Review of the literature. Int J Otolaryngol 2012;2012:291472. https://doi.org/10.1155/2012/291472
- Lin RJ, Sridharan S, Smith LJ, Young VN, Rosen CA. Weaning of proton pump inhibitors in patients with suspected laryngopharyngeal reflux disease. Laryngoscope 2018;128(1):133-7. https://doi.org/10.1002/lary.26696
- Eusebi LH, Rabitti S, Artesiani ML, Gelli D, Montagnani M, Zagari RM, et al. Proton pump inhibitors: Risks of long-term use. J Gastroenterol Hepatol 2017;32(7):1295-302. https://doi.org/10.1111/jgh.13737