The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Investigation of Effective Korean Herbal Medicine for Psoriasis - Focusing on Lipid Metabolism -

건선에 효과적인 한약 처방 탐색 - 지질 대사를 중심으로

  • Han, Chang-Yi (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Jundong (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Seo, Gwang-Yeel (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Kyu-Seok (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Yoon-Bum (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University)
  • 한창이 (경희대학교 한의과대학 안이비인후피부과) ;
  • 김준동 (경희대학교 한의과대학 안이비인후피부과) ;
  • 서광일 (경희대학교 한의과대학 안이비인후피부과) ;
  • 김규석 (경희대학교 한의과대학 안이비인후피부과) ;
  • 김윤범 (경희대학교 한의과대학 안이비인후피부과)
  • Received : 2021.07.02
  • Accepted : 2021.08.02
  • Published : 2021.08.25
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Abstract

Objectives : The purpose of this study is to investigate the possibility of using herbal medicine for the management of psoriasis focusing on lipid metabolism. Methods : We reviewed studies about pathophysiology, and medical treatment of psoriasis, the relationship between psoriasis and metabolic syndrome and lipid metabolism, and herbal medicine on Pubmed and Google scholar. Results : Psoriasis is a chronic multi-organ inflammatory disease not limited to skin, and steroids, immuno-suppressants, and biological agents are used. It is known that psoriasis and metabolic syndrome act as mutual risk factors, and lipid metabolism are involved in psoriasis. The effects of various single herbal preparations and complex herbal extract, decoction on improving lipid metabolism have been consistently reported, and there was an improvement of psoriatic skin lesions and improvement of blood lipid levels through herbal medicine. Conclusions : Herbal medicine research in psoriasis has focused on the anti-inflammatory effect and the suppression effect of certain immune mediators. However, considering that psoriasis is affected by lipid metabolism and side effects of Western medicines, the use of herbal medicines for the purpose of controlling lipid metabolism in psoriasis is useful in aspects of reducing side effects of concurrent Western medicine, improving the severity of psoriasis, and managing metabolic risk factors.

Keywords

References

  1. The Society of Korean Dermatology. Textbook of Dermatology. 6th ed. Seoul; Daehan Medical book. 2015:299-314.
  2. Youn SW. Recent medical therapy for psoriasis. J Korean Med Assoc. 2019;62 (3):176-80. https://doi.org/10.5124/jkma.2019.62.3.176
  3. Pietrzak A, Michalak-Stoma A, Chodorowska G, Szepietowski JC. Lipid disturbances in psoriasis: An update. Mediators of Inflammation. 2010;2010:1-13.
  4. Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M. Risk factors for the development of psoriasis. Int J Mol Sci. 2019;20(18):1-14.
  5. Takeshita J, Grewal S, Langan SM, Mehta NN, Ogdie A, Van Voorhees AS, et al. Psoriasis and comorbid diseases: Implications for management. J Am Acad Dermatol. 2017;76(3):393-403. https://doi.org/10.1016/j.jaad.2016.07.065
  6. Armstrong AW, Read C. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. J Am Med Assoc. 2020;323(19):1945-60. https://doi.org/10.1001/jama.2020.4006
  7. Lee S. Psoriasis and Skin Barrier. J Ski Barrier Res. 2017;19(1):25-9.
  8. Han CY, Kim JD, Kang DW, Kim KS, Kim YB. Review about using Herbal medicine on steroid tapering and steroid overuse in Skin disease. J Korean Med Ophthalmol Otolaryngol Dermatol. 2020;33(3):115-24. https://doi.org/10.6114/JKOOD.2020.33.3.115
  9. Rendon A, Schakel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20 (6):1-28.
  10. Ogawa E. Sato Y, Minagawa A, Okuyama R. Pathogenesis of psoriasis and development of treatment. J Der. 2018;45:264-72.
  11. Gisondi P, Fostini AC, Fossa I, Girolomoni G, Targher G. Psoriasis and the metabolic syndrome. Clin Dermatol. 2018;36(1):21-8. https://doi.org/10.1016/j.clindermatol.2017.09.005
  12. Pietrzak A, Chodorowska G, Szepietowski J, Zalewska-Janowska A, Krasowska D, Hercogova J. Psoriasis and serum lipid abnormalities. Dermatol Ther. 2010;23(2): 160-73. https://doi.org/10.1111/j.1529-8019.2010.01311.x
  13. Grozdev I, Korman N, Tsankov N. Psoriasis as a systemic disease. Clin Dermatol. 2014;32(3):343-50. https://doi.org/10.1016/j.clindermatol.2013.11.001
  14. Kang DW, Han CY, Kim JD, Kim KS, Kim YB. A Proposal and Considerations for Treatment Approaches of Psoriasis. J Korean Med Ophthalmol Otolaryngol Dermatol. 2020;33(3):99-114. https://doi.org/10.6114/JKOOD.2020.33.3.099
  15. Asad F, Khan M, Rizvi F. Atorvastatin as an adjuvant with betamethasone valerate reduces disease severity and cardiovascular risks in Psoriasis. Pakistan J Med Sci. 2017;33(6):1507-11.
  16. Zuccotti E, Oliveri M, Girometta C, Ratto D, Di Iorio C, Occhinegro A, et al. Nutritional strategies for psoriasis: Current scientific evidence in clinical trials. Eur Rev Med Pharmacol Sci. 2018;22(23):8537-51.
  17. Upala S, Sanguankeo A. Effect of lifestyle weight loss intervention on disease severity in patients with psoriasis: A systematic review and meta-analysis. Int J Obes. 2015;39(8):1197-202. https://doi.org/10.1038/ijo.2015.64
  18. Sarvtin MT, Hedayati MT, Shokohi T, HajHeydari Z. Serum lipids and lipoproteins in patients with psoriasis. Arch Iran Med. 2014;17(5):343-6.
  19. Shih CM, Chen CC, Chu CK, Wang KH, Huang CY, Lee AW. The roles of lipoprotein in psoriasis. Int J Mol Sci. 2020;21(3):1-12.
  20. Sorokin AV, Domenichiello AF, Dey AK, Yuan ZX, Goyal A, Rose SM, et al. Bioactive Lipid Mediator Profiles in Human Psoriasis Skin and Blood. J Invest Dermatol. 2018;138(7):1518-28. https://doi.org/10.1016/j.jid.2018.02.003
  21. Kim BH, Kim KI, Kang SH, Park JG, Kang DW, Nam HJ, et al. Explanation and Elaboration of the Clinical Trial Guidelines for Psoriasis Using Herbal Medicine. J Korean Med Ophthalmol Otolaryngol Dermatol. 2018;31(2):40-59. https://doi.org/10.6114/JKOOD.2018.31.2.040
  22. Jeung CW, Jeon SW, Jo HG. Literature Review on Herbal Medicine Treatment of Psoriasis Based on Chronic Low-grade Inflammation Theory. J Korean Med Ophthalmol Otolaryngol Dermatol. 2018;31 (4):22-30. https://doi.org/10.6114/JKOOD.2018.31.4.022
  23. Sun W, Gao Y, Yu X, Yuan Y, Yi J, Zhang Z, et al. 'Psoriasis 1' reduces psoriasis-like skin inflammation by inhibiting the VDRmediated nuclear NF-kB and STAT signaling pathways. Mol Med Rep. 2018;18(3): 2733-43.
  24. Yan Y, Liu W, Andres P, Pernin C, Chantalat L, Briantais P, et al. Exploratory clinical trial to evaluate the efficacy of a topical traditional Chinese herbal medicine in psoriasis vulgaris. Evid Based Complement Alternat Med. 2015;201:719641.
  25. Weng SW, Chen BC, Wang YC, Liu CK, Sun MF, Chang CM, et al. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study. Evid Based Complement Alternat Med. 2016;2016:3164105.
  26. Rouhi-Boroujeni H, Rouhi-Boroujeni H, Heidarian E, Mohammadizadeh F, RafieianKopaei M. Herbs with anti-lipid effects and their interactions with statins as a chemical anti-hyperlipidemia group drugs: A systematic review. ARYA Atheroscler. 2015;11(4):244-51.
  27. Yokoi H, Mizukami H, Nagatsu A, Ohno T, Tanabe H, Inoue M. Peroxisome Proliferator- Activated Receptor g Ligands Isolated from Adlay Seed. Biol Pharm Bull. 2009;32(4):735-40. https://doi.org/10.1248/bpb.32.735
  28. Song MY, Jung HW, Park YK. Antiobesity Effect of Water Extract of Coix lacrymajobi var. mayuen in High Fat Fed C5BL/6 Mice. J Korean Med Obes Res. 2016;16(1):27-35. https://doi.org/10.15429/jkomor.2016.16.1.27
  29. Kim BM, Jo HG. Progress of Short-term Herbal Medicine Administration for Hypertriglyceridemia: a Case Report. J. Int. Korean Med. 2019;40(3):517-24. https://doi.org/10.22246/jikm.2019.40.3.517
  30. Kim DS, Jeon BK, Mun YJ, Lee GT, Lee KK, Woo WH. Ponciri Fructus Extract Induces Lipogenesis through Transcription Factor SREBP-1 Activation. Yakhak Hoeji. 2012; 56(4):268-73.
  31. Wu F, Yang X, Hu M, Shao Q, Fang K, Li J, et al. Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function. Phytomedicine. 2020;76:153258. https://doi.org/10.1016/j.phymed.2020.153258
  32. Sin SM, Cha JH, Kim GT, Byun SH, Ko H. Saenggangeonbi-tang's effest on metabolic syndrome Department. J Intern Korean Med. 2008;fal:65-70.
  33. Lee IW, Choi HY, Lee JH, Park SD, Kim SM, Ku SK, et al. Saeng-Kankunbi-Tang protects liver against oxidative damage through activation of ERK/Nrf2 pathway. Chin J Integr Med. 2016;22(8):619-28. https://doi.org/10.1007/s11655-016-2466-5
  34. Masayuki I, Takashi S, Koh I, Kazuichi S. Chinese Herbal Medicine Yi-Gan-San Decreases the Lipid Accumulation in Mouse 3T3-L1 Adipocytes by Modulating the Activities of Transcription Factors SREBP-1c and FoxO1. Tohoku J. Exp. Med. 2009; 219:53-62. https://doi.org/10.1620/tjem.219.53
  35. Lee JM, Cho SW, Kang KH, Lee SY, Yu S. The Effects of Daecheongryong-tang on transcription factors and adipogenic genes during 3T3-L1 differentiation. The Journal of Pediatrics of Korean Medicine. 2010; 24(3):92-105.
  36. Xie X, Zhang L, Li X, Liu W, Wang P, Lin Y, et al. Liangxue Jiedu Formula Improves Psoriasis and Dyslipidemia Comorbidity via PI3K/Akt/mTOR Pathway. Front Pharmacol. 2021;12:1-13.
  37. Cho JG, Yang YH, Han SR, Cho AR. 3 Cases Reports of Psoriasis Treated by Damwihwan- Focused on Lipid Metabolic Abnomarilty. J Korean Med Ophthalmol Otolaryngol Dermatol 2017;30(4):167-75. https://doi.org/10.6114/jkood.2017.30.4.167