Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Effect of Fruits from Pyrus ussuriensis var. hakunensis (Nakai) T.B. Lee on Macrophage Activation

산돌배(Pyrus ussuriensis var. hakunensis (Nakai) T.B. Lee) 열매의 대식세포 활성화 유도 활성

  • Geum, Na Gyeong (Department of Medicinal Plant Resources, Andong National University) ;
  • Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
  • 금나경 (국립안동대학교 생약자원학과) ;
  • 정진부 (국립안동대학교 생약자원학과)
  • Received : 2021.05.27
  • Accepted : 2021.06.22
  • Published : 2021.08.01
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Abstract

In this study, we investigated in vitro immunostimulatory activity of fruit extracts from Pyrus ussuriensis var. hakunensis (Nakai) T.B. Lee (PUF) using mouse macrophage RAW264.7 cells. PUF increased the production of immunostimulatory factors such as NO, iNOS, IL-1β, IL-6 and TNF-α, and phagocytic activity in RAW264.7 cells. The inhibition of TLR2 and TLR4 blocked PUF-mediated production of immunostimulatory factors in RAW264.7 cells. In addition, the inhibition of MAPKs signaling pathway reduced PUF-mediated production of immunostimulatory factors. From these results, PUF may have immunostimulatory activity via TLR2/4-mediated activation of MAPKs signaling pathway. Therefore, PUF expected to be used as a potential immune-enhancing agent.

이상의 연구 결과로 미루어 볼 때, 산돌배 열매추출물은 대식세포에서 TLR2와 TLR4를 자극하여 MAPKs 신호전달을 활성화하여 NO, iNOS, IL-1𝛽, IL-6 및 TNF-α와 같은 면역증진 인자의 생성을 유도하고, 대식세포의 포식작용을 활성화시키는 것으로 판단된다. 따라서 산돌배 추출물은 대식세포의 활성화를 통해 인체의 면역시스템을 강화할 수 있으므로, 향후 면역 보조제나 면역증진을 위한 기능성 식의약품 개발을 위한 소재로 활용이 가능할 것으로 생각한다.

Keywords

Acknowledgement

본 논문은 산림청(한국임업진흥원) 산림과학기술 연구개발 사업(2021377C10-2123-BD02)과 한국연구재단 이공분야 기초연구사업 중점연구소지원사업(NRF-2018R1A6A1A03024862)의 지원으로 이루어진 결과로 이에 감사드립니다.

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