Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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The FMRFamide Neuropeptide FLP-20 Acts as a Systemic Signal for Starvation Responses in Caenorhabditis elegans

  • Kang, Chanhee (School of Biological Sciences, Seoul National University) ;
  • Avery, Leon (Department of Molecular Biology, UT Southwestern Medical Center)
  • Received : 2021.03.01
  • Accepted : 2021.04.08
  • Published : 2021.07.31
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Abstract

Most animals face frequent periods of starvation throughout their entire life and thus need to appropriately adjust their behavior and metabolism during starvation for their survival. Such adaptive responses are regulated by a complex set of systemic signals, including hormones and neuropeptides. While much progress has been made in identifying pathways that regulate nutrient-excessive states, it is still incompletely understood how animals systemically signal their nutrient-deficient states. Here, we showed that the FMRFamide neuropeptide FLP-20 modulates a systemic starvation response in Caenorhabditis elegans. We found that mutation of flp-20 rescued the starvation hypersensitivity of the G protein β-subunit gpb-2 mutants by suppressing excessive autophagy. FLP-20 acted in AIB neurons, where the metabotropic glutamate receptor MGL-2 also functions to modulate a systemic starvation response. Furthermore, FLP-20 modulated starvation-induced fat degradation in a manner dependent on the receptor-type guanylate cyclase GCY-28. Collectively, our results reveal a circuit that senses and signals nutrient-deficient states to modulate a systemic starvation response in multicellular organisms.

Keywords

Acknowledgement

We thank Scott Cameron, Beth Levine, Melanie Cobb, Alexander Soukas, Merav Cohen, Niels Ringstad, members of the Avery and Cameron laboratories for helpful discussions, Cori Bargmann, Kevin Ashrafi, Maureen Barr, Mario De Bono, Merav Cohen for providing strains and plasmids, the C. elegans Genetics Center and S. Mitani (National Bioresource Project) for providing strains, Yuji Kohara (National Institute of Genetics, Japan) for providing flp-20 cDNA. We are indebted to Cori Bargmann for the discussion about GCY-28 and for sharing unpublished data. This work was supported by grants from the POSCO Science Fellowship of POSCO TJ Park Foundation, the SNU invitation program for the distinguished scholar, and the U.S. Public Health Service (HL46154).

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