Journal of the Health Care and Life Science (보건의료생명과학 논문지)

The Korean Society of Medical Informatics Education (한국의료정보교육협회)
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The association of vitamin D and urine microalbumin/creatinine and obesity in Korean adults

한국 여성에서 혈청 ferritin과 25-hydroxyvitamin D 및 대사 증후군의 관련성

  • Choi, Jung-Hun (Department of Health and Medical Sciences, Graduate School of Dongshin University) ;
  • Kim, Sung-Gil (Department of Radiology, Hanlyo University) ;
  • Eun, Sung-Jong (Department of Radiology, Hanlyo University) ;
  • Song, Mi-Ok (Department of Early childhood Education, Donggang University)
  • 최정훈 (동신대학교 대학원 보건의료학과) ;
  • 김성길 (한려대학교 방사선과) ;
  • 은성종 (한려대학교 방사선과) ;
  • 송미옥 (동강대학교 유아교육과)
  • Received : 2021.06.04
  • Accepted : 2021.07.05
  • Published : 2021.07.30
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Abstract

The present study was conducted to assess the association between serum ferritin and 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome (MetS) in Korean women. The data of a total of 9,256 adults (4,196 premenopausal women and 4,340 postmenopausal women) aged ≥ 20 years from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V) (2010-2012) were analyzed. The key study results were as follows: First, in women without MetS, after adjusting for related variables (age, smoking, alcohol consumption, regular exercise, SBP, DBP, WM, TC, TGs, HDL-C, FPG, Hb, Hct, and Fe), vitamin D status was positively associated with serum ferritin levels (premenopausal, p < 0.001; postmenopausal, p = 0.027). Second, in women with MetS, after adjusting for related variables, vitamin D status was not associated with serum ferritin levels (premenopausal, p = 0.739; postmenopausal, p = 0.278). In conclusions, vitamin D status was positively associated with serum ferritin levels in women without MetS but not in women with MetS.

본 연구는 한국 여성에서 혈청 ferritin과 25-hydroxyvitamin D [25 (OH) D]와 대사 증후군 (MetS)의 관련성을 평가하기 위해 시행되었다. 다섯 번째 국민 건강 영양 조사 (KNHANES V) (2,010- 2,012)에서 ≥ 20세 이상 성인 9,256명(4,196 폐경 전 여성과 폐경 후 여성 4,340)의 데이터를 분석 하였다. 주요 연구 결과는 다음과 같다. 첫째, MetS가 없는 여성의 경우 관련 변수 (연령, 흡연, 음주, 규칙적인 운동, SBP, DBP, WM, TC, TG, HDL-C, FPG, Hb, Hct)를 조정 한 후, 비타민 D 상태는 혈청 ferritin 수치와 관련이 있었다 (폐경 전, p <0.001, 폐경 후, p = 0.027). 둘째, MetS를 가진 여성에서 비타민 D 상태는 혈청 ferritin 수치와 관련이 없었다 (폐경 전, p = 0.739, 폐경 후, p = 0.278). 결론적으로, 비타민 D 상태는 MetS가 없는 여성에서는 혈청 ferritin 수준과 양의 상관 관계가 있었지만 MetS가 있는 여성에서는 그렇지 않았다.

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References

  1. J. Cook, C. Flowers and B. Skikne, 'The quantitative assessment of body iron'. Blood. Vol. 101, pp.3359-3364, 2003 https://doi.org/10.1182/blood-2002-10-3071
  2. S-J. Chon, Y-R. Choi, Y-H. Roh, B-H. Yun, S. Cho, Y-S. Choi AND B-S. Lee, 'Association between levels of serum ferritin and bone mineral density in Korean premenopausal and postmenopausal women: KNHANES 2008-2010', PLoS One, Vol. 9, e114972, 2014. https://doi.org/10.1371/journal.pone.0114972
  3. J-A. Lee, J-S. Hwang, I-T. Hwang, D-H. Kim, J-H. Seo and J-S. Lim, 'Low vitamin D levels are associated with both iron deficiency and anemia in children and adolescents', Pediatr Hematol Oncol, Vol. 32, pp.99-108, 2015. https://doi.org/10.3109/08880018.2014.983623
  4. H. Rasheed, D. Mahgoub, R. Hegazy, M. El-Komy, R. Abdel, M. Hamid and E. Hamd, 'Serum ferritin and vitamin d in female hair loss: do they play a role', Skin Pharmacol Physiol, Vol. 26, pp.101-107, 2013. https://doi.org/10.1159/000346698
  5. Y-S. Cho, J-H. Kang, S-A. Kim, K-W. Shim and H-S. Lee, 'Association of serum ferritin and abdominal obesity and insulin resistance', J Korean Soc Study Obes, Vol.14, pp.76-81, 2015.
  6. M. Jehn, J. Clark and E. Guallar, 'Serum ferritin and risk of the metabolic syndrome in U.S. adults', Diabetes Care, Vol.27, pp.2422-2428, 2004. https://doi.org/10.2337/diacare.27.10.2422
  7. M. Williams, R. Poulton and S. Williams, 'Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women'. Atherosclerosis. Vol.165, pp.179-184, 2002. https://doi.org/10.1016/S0021-9150(02)00233-2
  8. M. Holick, 'Vitamin D deficiency'. N Engl J Med. Vol.357, pp.266-281, 2007. https://doi.org/10.1056/NEJMra070553
  9. A. Karadag, D. Ertugrul, E. Tutal and K. Akin, 'The role of anemia and vitamin D levels in acute and chronic telogen effluvium'. Turk J Med Sci. Vol.41, pp.827-833, 2011.
  10. Y-C. Ku, M-E. Liu, C-S. Ku, T-Y. Liu and S-L. Lin. 'Relationship between vitamin D deficiency and cardiovascular disease'. World J Cardiol. Vol.5, pp.337-346, 2013. https://doi.org/10.4330/wjc.v5.i9.337
  11. J-J. Sim, P-T. Lac, I-L. Liu, S-O. Meguerditchian, V-A. Kumar, D-A. Kujubu and S-A. 'Rasgon. Vitamin D deficiency and anemia: a cross-sectional study'. Ann Hematol. Vol.89, pp.447-452, 2019. https://doi.org/10.1007/s00277-009-0850-3
  12. H. Yoon, G-S. Kim, S-G. Kim and A-E. Moon. 'The Relationship between Metabolic Syndrome and Increase of Metabolic Syndrome Score and Serum Vitamin D Levels in Korean Adults: 2012 Korean National Health and Nutrition Examination Survey'. J Clin Biochem Nutr. Vol.57, pp.82-87, 2015. https://doi.org/10.3164/jcbn.15-31
  13. D-W. Jeong, H-W. Lee, Y-H. Cho, D-W. Yi, S-Y. Lee, S-M. Son and Y-H. Kang. 'Comparison of serum ferritin and vitamin d in association with the severity of nonalcoholic Fatty liver disease in Korean adults'. Endocrinol Metab (Seoul). Vol.29, pp.479-488, 2014. https://doi.org/10.3803/EnM.2014.29.4.479
  14. C. Thomas, R. Guillet, R. Queenan, E. Cooper, T. Kent, E. Pressman and F. Vermeylen. 'Vitamin D status is inversely associated with anemia and serum erythropoietin during pregnancy'. Am J Clin Nutr. Vol.102, pp.1088-1095, 2015. https://doi.org/10.3945/ajcn.115.116756
  15. WHO. Western Pacific Region. International Association for the Study of Obesity Task Force, The Asia-Pacific Perspective: Redefining Obesity and its Treatment, Health Communications Australia, Sydney, Australia. 2000.
  16. H. Yoon, D-J. Jeon, C-E. Park, H-S. You and A-E. Moon. 'Relationship between homeostasis model assessment of insulin resistance and beta cell function and serum 25-hydroxyvitamin D in non-diabetic Korean adults'. J Clin Biochem Nutr. Vol.59, pp.139-144, 2016. https://doi.org/10.3164/jcbn.15-143
  17. L. Zgaga, E. Theodoratou, S. Farrington, F. Agakov, A. Tenesa, M. Walker and S. Knox. 'Diet, environmental factors, and lifestyle underlie the high prevalence of vitamin D deficiency in healthy adults in Scotland, and supplementation reduces the proportion that are severely deficient'. J Nutr. Vol.11, No.141, pp.1535-1542, 2014.
  18. Y. Zhan, Z. Tang and J. Yu. 'Serum ferritin, diabetes, diabetes control, and insulin resistance'. Acta Diabetol. Vol.51, pp.991-998, 2014. https://doi.org/10.1007/s00592-014-0656-1
  19. B. Ilkovska, B. Kotevska and G. Trifunov. 'Elevated Serum Hepcidin and Ferritin Levels in Patients With Metabolic Syndrome in Macedonian'. IJAR. Vol.5, pp.267-269, 2015.
  20. N. Martinelli, M. Traglia, N. Campostrini, G. Biino, M. Corbella, C. Sala and F. Busti. 'Increased serum hepcidin levels in subjects with the metabolic syndrome: a population study'. PLoS One. Vol.7, e48250, 2012. https://doi.org/10.1371/journal.pone.0048250
  21. B. Garcia-Bailo, A. El-Sohemy, P. Haddad, P. Arora, F. Benzaied, M. Karmali and A. Badawi. 'Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: modulation of inflammation and oxidative stress'. Biologics. Vol.5, pp.7-19, 2015. https://doi.org/10.2147/BTT.S14417
  22. A. Talaei, M. Mohamadi and Z. Adgi. 'The effect of vitamin D on insulin resistance in patients with type 2 diabetes'. Diabetol Metab Syndr. Vol.5, No8, 2013.
  23. D. Kell and E. Pretorius. 'Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells'. Metallomics. Vol.6, pp.748-773, 2014. https://doi.org/10.1039/C3MT00347G
  24. K. Orino, L. Lehman, Y. Tsuji, H. Ayaki, S. Torti and F. Torti. 'Ferritin and the response to oxidative stress'. Biochem J. Vol.357, pp.241-247, 2001. https://doi.org/10.1042/bj3570241