Acknowledgement
This work was partially supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (2020R1A5A2017476 and 2020R1A2C1011976), and Bio & Medical Technology Development Program (2017M3A9D8063627).
References
- Manser E, Loo TH, Koh CG et al (1998) PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell 1, 183-192 https://doi.org/10.1016/S1097-2765(00)80019-2
- Oh WK, Yoo JC, Jo D, Song YH, Kim MG and Park D (1997) Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun 235, 794-798 https://doi.org/10.1006/bbrc.1997.6875
- Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L and Cerione RA (1998) A novel regulator of p21-activated kinases. J Biol Chem 273, 23633-23636 https://doi.org/10.1074/jbc.273.37.23633
- Kim S, Lee SH and Park D (2001) Leucine zipper-mediated homodimerization of the p21-activated kinase-interacting factor, beta Pix. Implication for a role in cytoskeletal reorganization. J Biol Chem 276, 10581-10584 https://doi.org/10.1074/jbc.C000806200
- Premont RT, Perry SJ, Schmalzigaug R, Roseman JT, Xing Y and Claing A (2004) The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factors. Cell Signal 16, 1001-1011 https://doi.org/10.1016/S0898-6568(04)00023-3
- Schlenker O and Rittinger K (2009) Structures of dimeric GIT1 and trimeric beta-PIX and implications for GIT-PIX complex assembly. J Mol Biol 386, 280-289 https://doi.org/10.1016/j.jmb.2008.12.050
- Shin EY, Shin KS, Lee CS et al (2002) Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. J Biol Chem 277, 44417-44430 https://doi.org/10.1074/jbc.M203754200
- Shin EY, Lee CS, Yun CY et al (2014) Non-muscle myosin II regulates neuronal actin dynamics by interacting with guanine nucleotide exchange factors. PLoS One 9, e95212 https://doi.org/10.1371/journal.pone.0095212
- Za L, Albertinazzi C, Paris S, Gagliani M, Tacchetti C and de Curtis I (2006) betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1. J Cell Sci 119, 2654-2666 https://doi.org/10.1242/jcs.02996
- Lee CS, Choi CK, Shin EY, Schwartz MA and Kim EG (2010) Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases. J Cell Biol 190, 663-674 https://doi.org/10.1083/jcb.201003057
- Mo J, Lee D, Hong S et al (2012) Preso regulation of dendritic outgrowth through PI(4,5)P2-dependent PDZ interaction with betaPix. Eur J Neurosci 36, 1960-1970 https://doi.org/10.1111/j.1460-9568.2012.08124.x
- Llano O, Smirnov S, Soni S et al (2015) KCC2 regulates actin dynamics in dendritic spines via interaction with beta-PIX. J Cell Biol 209, 671-686 https://doi.org/10.1083/jcb.201411008
- Kim S, Ko J, Shin H et al (2003) The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo. J Biol Chem 278, 6291-6300 https://doi.org/10.1074/jbc.M212287200
- Saneyoshi T, Wayman G, Fortin D et al (2008) Activitydependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron 57, 94-107 https://doi.org/10.1016/j.neuron.2007.11.016
- Shin MS, Song SH, Shin JE, Lee SH, Huh SO and Park D (2019) Src-mediated phosphorylation of betaPix-b regulates dendritic spine morphogenesis. J Cell Sci 132, 1-17
- Hirokawa N, Noda Y, Tanaka Y and Niwa S (2009) Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol 10, 682-696 https://doi.org/10.1038/nrm2774
- Bloom GS, Wagner MC, Pfister KK and Brady ST (1988) Native structure and physical properties of bovine brain kinesin and identification of the ATP-binding subunit polypeptide. Biochemistry 27, 3409-3416 https://doi.org/10.1021/bi00409a043
- Kanai Y, Okada Y, Tanaka Y, Harada A, Terada S and Hirokawa N (2000) KIF5C, a novel neuronal kinesin enriched in motor neurons. J Neurosci 20, 6374-6384 https://doi.org/10.1523/JNEUROSCI.20-17-06374.2000
- Kirchner J, Seiler S, Fuchs S and Schliwa M (1999) Functional anatomy of the kinesin molecule in vivo. EMBO J 18, 4404-4413 https://doi.org/10.1093/emboj/18.16.4404
- Seiler S, Kirchner J, Horn C, Kallipolitou A, Woehlke G and Schliwa M (2000) Cargo binding and regulatory sites in the tail of fungal conventional kinesin. Nat Cell Biol 2, 333-338 https://doi.org/10.1038/35014022
- Gindhart JG Jr and Goldstein LS (1996) Tetratrico peptide repeats are present in the kinesin light chain. Trends Biochem Sci 21, 52-53 https://doi.org/10.1016/S0968-0004(96)80180-0
- Gindhart JG (2006) Towards an understanding of kinesin-1 dependent transport pathways through the study of protein-protein interactions. Brief Funct Genomic Proteomic 5, 74-86 https://doi.org/10.1093/bfgp/ell002
- Nakata T and Hirokawa N (2007) Neuronal polarity and the kinesin superfamily proteins. Sci STKE 2007, pe6
- Ferreira A, Niclas J, Vale RD, Banker G and Kosik KS (1992) Suppression of kinesin expression in cultured hippocampal neurons using antisense oligonucleotides. J Cell Biol 117, 595-606 https://doi.org/10.1083/jcb.117.3.595
- Purpura DP (1974) Dendritic spine "dysgenesis" and mental retardation. Science 186, 1126-1128 https://doi.org/10.1126/science.186.4169.1126
- Ramakers GJ (2002) Rho proteins, mental retardation and the cellular basis of cognition. Trends Neurosci 25, 191-199 https://doi.org/10.1016/S0166-2236(00)02118-4
- Park E, Na M, Choi J et al (2003) The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. J Biol Chem 278, 19220-19229 https://doi.org/10.1074/jbc.M301052200
- Ko J, Kim S, Valtschanoff JG et al (2003) Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. J Neurosci 23, 1667-1677 https://doi.org/10.1523/JNEUROSCI.23-05-01667.2003