Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Bone Homeostasis and Gut Microbial-Dependent Signaling Pathways

  • Zhong, Xiaohui (Wuxi School of Medicine, Jiangnan University) ;
  • Zhang, Feng (Wuxi School of Medicine, Jiangnan University) ;
  • Yin, Xinyao (Wuxi School of Medicine, Jiangnan University) ;
  • Cao, Hong (Clinical Assessment Center of Functional Food, Affiliated Hospital of Jiangnan University) ;
  • Wang, Xuesong (Wuxi School of Medicine, Jiangnan University) ;
  • Liu, Dongsong (Department of Orthopedics, Affiliated Hospital of Jiangnan University) ;
  • Chen, Jing (Department of Orthopedics, Affiliated Hospital of Jiangnan University) ;
  • Chen, Xue (Wuxi School of Medicine, Jiangnan University)
  • Received : 2021.04.12
  • Accepted : 2021.06.13
  • Published : 2021.06.28
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Abstract

Although research on the osteal signaling pathway has progressed, understanding of gut microbial-dependent signaling pathways for metabolic and immune bone homeostasis remains elusive. In recent years, the study of gut microbiota has shed light on our understanding of bone homeostasis. Here, we review microbiota-mediated gut-bone crosstalk via bone morphogenetic protein/SMADs, Wnt and OPG/receptor activator of nuclear factor-kappa B ligand signaling pathways in direct (translocation) and indirect (metabolite) manners. The mechanisms underlying gut microbiota involvement in these signaling pathways are relevant in immune responses, secretion of hormones, fate of osteoblasts and osteoclasts and absorption of calcium. Collectively, we propose a signaling network for maintaining a dynamic homeostasis between the skeletal system and the gut ecosystem. Additionally, the role of gut microbial improvement by dietary intervention in osteal signaling pathways has also been elucidated. This review provides unique resources from the gut microbial perspective for the discovery of new strategies for further improving treatment of bone diseases by increasing the abundance of targeted gut microbiota.

Keywords

Acknowledgement

We thank the support of general program of National Natural Science Foundation of China (81870544), project of Wuxi Municipal Bureau on Science and Technology (N20192025) and general research project of Public Health Research Center of Jiangnan University (JUPH201808).

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