The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Clinical Research Trends of Gut Microbiome for Respiratory Diseases

호흡기질환에 대한 장내 미생물의 임상 연구 동향

  • Lee, Su Won (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Choi, Jin Kwan (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Yang, Won Kyung (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University) ;
  • Kim, Seung Hyung (Institute of Traditional Medicine and Bioscience, Daejeon University) ;
  • Lyu, Yee Ran (Korean Institute of Oriental Medicine) ;
  • Park, Yang Chun (Division of Respiratory Medicine, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University)
  • 이수원 (대전대학교 한의과대학 폐계내과학교실) ;
  • 최진관 (대전대학교 한의과대학 폐계내과학교실) ;
  • 양원경 (대전대학교 한의과대학 폐계내과학교실) ;
  • 김승형 (대전대학교 동서생명과학연구원) ;
  • 유이란 (한국한의학연구원) ;
  • 박양춘 (대전대학교 한의과대학 폐계내과학교실)
  • Received : 2021.05.03
  • Accepted : 2021.07.28
  • Published : 2021.09.01
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Abstract

Objectives: This study aimed to review the clinical research of the gut microbiome for respiratory diseases to assist the design of trials for respiratory diseases by regulating the gut microbiome with herbal medicine later. Methods: We searched three international databases (PubMed, CENTRAL and EMBASE) to investigate randomized controlled trials (RCTs) of the gut microbiome for respiratory diseases. The selected trials were analyzed by study design, subject diseases, inclusion/exclusion criteria, sample size, study period, intervention group, control group, outcome measures, and study results. Results: A total of 25 studies were included and published from 1994 to 2021 mostly in Europe and Asia. Subject diseases were many in the order of respiratory tract infection, cystic fibrosis, allergy, and so on. As outcome measures, the gut microbiome in a fecal sample was analyzed by 16S rRNA sequencing analysis method, and symptom assessment tools related each disease were used. Major intervention drugs were probiotics and the results were mostly improved in the composition and diversity of the gut microbiome. Conclusion: Clinical studies of the gut microbiome for respiratory diseases have confirmed various effects and this review provides basic data for a well-designed clinical study for respiratory diseases by regulating the gut microbiome with herbal medicine.

Keywords

Acknowledgement

본 연구는 2019년도 한국연구재단의 지원(과제번호: RF2019R1A2C1087201)을 받아 수행되었음.

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